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Protein Tyrosine Phosphatase-Like (Proline Instead of Catalytic Arginine), Member A ELISA Kits (PTPLA)
On www.antibodies-online.com are 6 Protein Tyrosine Phosphatase-Like (Proline Instead of Catalytic Arginine), Member A (PTPLA) ELISA Kits from 5 different suppliers available. Additionally we are shipping PTPLA Antibodies (36) and and many more products for this protein. A total of 46 PTPLA products are currently listed.
Synonyms:
2010309L07Rik, 4732490P18Rik, CAP, gp160, HACD1, IRAP, PLAP, vp165
list all ELISA KIts Gene Name GeneID UniProt
Mouse PTPLA PTPLA 240028 Q8C129
PTPLA 9200 B0YJ81

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Mouse (Murine) Protein Tyrosine Phosphatase-Like (Proline Instead of Catalytic Arginine), Member A (PTPLA) interaction partners

  1. Data reveal that HACD1 is a key regulator of a lipid-dependent muscle fibre growth mechanism.

  2. Mutations in HACD1 can result in myopathies in humans; knockout mice lacking Hacd1 develop myopathic phenotypes. Data (including data from studies using knockout mice and cultured cells from knockout mice) suggest that HACD1 and HACD2 (show PTPLB ELISA Kits) exhibit overlapping substrate specificities and thus appear to represent redundant activities in skeletal muscle.

  3. this paper shows that endosomal retention of TLR9 (show TLR9 ELISA Kits) via the interaction of IRAP (show IL1RN ELISA Kits) with the actin cytoskeleton is a mechanism that prevents hyper-activation of TLR9 (show TLR9 ELISA Kits) in dendritic cells

  4. IRAP (show IL1RN ELISA Kits) is more highly expressed in pro-inflammatory M1-activated macrophages.

  5. IRAP (show IL1RN ELISA Kits) deficiency may lead to suppression of PAI-1 (show SERPINE1 ELISA Kits) expression in adipocytes and upregulation of UCP-1 (show UCP1 ELISA Kits)-mediated thermogenesis in brown adipose tissue and increased energy expenditure to prevent the development of obesity.

  6. The current study demonstrates that deletion of the IRAP (show IL1RN ELISA Kits) gene protects the brain from ischemic damage

  7. IRAP (show IL1RN ELISA Kits)-deficient mice are less sensitive to the development of acute pentylenetetrazol-induced seizures, demonstrating that IRAP (show IL1RN ELISA Kits) may be involved in generalized seizure generation.

  8. requirement of IRAP (show IL1RN ELISA Kits) in cross-presentation extends to steady-state conventional dendritic cells (cDCs);data suggest increased recruitment of an IRAP (show IL1RN ELISA Kits)(+)/Rab14 (show RAB14 ELISA Kits)(+) compartment to Ag-containing vesicles contributes to cross-presentation efficacy of CD8 (show CD8A ELISA Kits)(+)cDCs

  9. Ptpla regulates myogenesis through Myog (show MYOG ELISA Kits).

  10. These findings suggest that the IRAP (show IL1RN ELISA Kits) binding protein, vimentin (show VIM ELISA Kits), plays an important role in retention of GLUT4 (show SLC2A4 ELISA Kits) storage vesicles.

Human Protein Tyrosine Phosphatase-Like (Proline Instead of Catalytic Arginine), Member A (PTPLA) interaction partners

  1. Labrador retrievers carrying two copies of a unique canine HACD1 loss-of-function allele that recently disseminated worldwide, are all affected by a congenital myopathy, confirming its role in muscle development.

  2. Longitudinal analyses in myopathic Labrador retrievers reveal several membrane-associated defects, including ultrastructural triads dysmorphogenesis and mitochondrial mislocalization in Labrador retrievers with deficiencies in the canine HACD1 gene.

  3. A loss-of-function mutation in the canine ortholog of HACD1 that was identified by genetic mapping in a French pedigree of Labrador retrievers causes a congenital myopathy named centronuclear myopathy (CNM (show MTM1 ELISA Kits)) in Labrador retrievers.

  4. Mutations in HACD1 can result in myopathies in humans; knockout mice lacking Hacd1 develop myopathic phenotypes. Data (including data from studies using knockout mice and cultured cells from knockout mice) suggest that HACD1 and HACD2 (show PTPLB ELISA Kits) exhibit overlapping substrate specificities and thus appear to represent redundant activities in skeletal muscle.

  5. These data indicate that HACD1 is necessary for muscle function.

  6. PTPLA-CAP expression was limited to cementum cells; promoted gingival fibroblast attachment. PTPLA-CAP is splice variant of PTPLA, and that, in the periodontium, cementum and cementum cells express this variant.

  7. HACD1 is 3-hydroxyacyl-CoA dehydratase (show PTPLAD2 ELISA Kits) involved in elongation of very long-chain fatty acids. HACD1 (K64Q) exhibits normal enzyme activity, intracellular localization and interaction with other VLCFA enzymes, with no negative effect on VLCFA elongation

  8. PTPLA SNPs show genotypic association with Alzheimer disease.

PTPLA Antigen Profile

Antigen Summary

The protein encoded by this gene contains a characteristic catalytic motif of the protein tyrosine phosphatases (PTPs) family. The PTP motif of this protein has the highly conserved arginine residue replaced by a proline residue\; thus it may represent a distinct class of PTPs. Members of the PTP family are known to be signaling molecules that regulate a variety of cellular processes. This gene was preferentially expressed in both adult and fetal heart. A much lower expression level was detected in skeletal and smooth muscle tissues, and no expression was observed in other tissues. The tissue specific expression in the developing and adult heart suggests a role in regulating cardiac development and differentiation.

Alternative names and synonyms associated with PTPLA

  • leucyl/cystinyl aminopeptidase (Lnpep) Elisa Kit
  • protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A (PTPLA) Elisa Kit
  • protein tyrosine phosphatase-like (proline instead of catalytic arginine), member a (Ptpla) Elisa Kit
  • 2010309L07Rik Elisa Kit
  • 4732490P18Rik Elisa Kit
  • CAP Elisa Kit
  • gp160 Elisa Kit
  • HACD1 Elisa Kit
  • IRAP Elisa Kit
  • PLAP Elisa Kit
  • vp165 Elisa Kit

Protein level used designations for PTPLA

OTase , cystinyl aminopeptidase , leucyl-cystinyl aminopeptidase , oxytocinase , 3-hydroxyacyl-CoA dehydratase 1 , cementum attachment protein , protein-tyrosine phosphatase-like member A , very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 1 , Protein-tyrosine phosphatase-like member A , protein tyrosine phosphatase-like, member a , protein tyrosine phosphatase-like protein PTPLA

GENE ID SPECIES
240028 Mus musculus
9200 Homo sapiens
30963 Mus musculus
574011 Canis lupus familiaris
443484 Ovis aries
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