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Cdon is required to localize N-cadherin (show CDH2 ELISA Kits) to the cell membrane in migratory neural crest cells for directed migration.
In the developing optic vesicle, Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hedgehog (show SHH ELISA Kits) protein, thereby limiting its dispersion.
We identified a novel heterozygous nonsense CDON mutation in a case of Pituitary Stalk Interruption Syndrome who presented with neonatal hypoglycemia and cholestasis
CDO (show CDO1 ELISA Kits) is required for proliferation and survival of lung cancer cells via Hh signaling.
These data support the view that cell-adhesion molecule (show MCAM ELISA Kits)-related/downregulated by oncogenes (CDON) acts as a tumor suppressor in neuroblastomas, and that CDON is tightly regulated by miRNAs.
Single-nucleotide polymorphism in CDON is associated with biochemical recurrence in prostate cancer.
Mutations in the CDON cause holoprosencephaly. (Review)
We found that CDON is overexpressed in prostate cancer
CDON must associate with both ligand and other hedgehog (show SHH ELISA Kits)-receptor components, particularly PTCH1 (show PTCH1 ELISA Kits), for signaling to occur and disruption of the latter interactions is a mechanism of holoprosencephaly.
Hedgehog (show SHH ELISA Kits) proteins interact with cell adhesion molecule (show MCAM ELISA Kits), down-regulated by oncogenes (CDO (show CDO1 ELISA Kits)) and brother of CDO (BOC (show BOC ELISA Kits)) in a conserved manner
CDO (show CDO1 ELISA Kits) and BOC (show BOC ELISA Kits) play a role in differentiation of cells in the skeletal muscle lineage
CDO (show CDO1 ELISA Kits) and BOC (show BOC ELISA Kits) forms complexes with specific cadherins that mediate some of the promyogenic effects of cell-cell contact.
Study assessed the role of the Shh (show SHH ELISA Kits) receptor Cdon in the development of ventral tegmental area and substantia nigra pars (show EPRS ELISA Kits) compacta dopamine neurons. Results suggest that Cdon plays an important role in the encoding of diversity within the population of dopamine neurons of the midbrain, influencing both the development of the mesocortical dopamine pathway as well as behavioral outputs that involve this neural circuitry.
Results suggest that a promyogenic cell adhesion molecule (show MCAM ELISA Kits) Cdo (show CDO1 ELISA Kits) signaling is critical for Inward rectifier potassium channel Kir2.1 (show KCNJ2 ELISA Kits) activities in the induction of myogenic differentiation.
PKN2 (show PKN2 ELISA Kits) formed complexes with Cdo (show CDO1 ELISA Kits), APPL1 (show APPL1 ELISA Kits) and AKT (show AKT1 ELISA Kits) via its C-terminal region and this interaction appeared to be important for induction of AKT (show AKT1 ELISA Kits) activity as well as myoblast differentiation.
that Cdon participates in oligodendrocyte differentiation and myelination, most likely in the initial stages of development
Suggest that Cdo (show CDO1 ELISA Kits) is required for the full Shh (show SHH ELISA Kits) signaling activation to induce efficient dopaminergic neuron neurogenesis.
Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1 (show PTCH1 ELISA Kits).
Cx43 (show GJA1 ELISA Kits) physically interacts with Cdo (show CDO1 ELISA Kits) to form dynamic complexes during myoblast differentiation
Stim1 (show STIM1 ELISA Kits) protein levels were decreased in Cdo (show CDO1 ELISA Kits)-deficient perinatal hindlimb muscles or primary myoblasts; this correlates with defective NFATc3 (show NFATC3 ELISA Kits) activation in Cdo (show CDO1 ELISA Kits)(-/-) myoblasts upon differentiation.
ASK1 (show MAP3K5 ELISA Kits) and TAK1 (show NR2C2 ELISA Kits) function as MAP3 kinases in Cdo (show CDO1 ELISA Kits)-mediated p38MAPK (show MAPK14 ELISA Kits) activation to promote myogenic differentiation.
Gas1 (show GAS1 ELISA Kits) cooperates with Cdo (show CDO1 ELISA Kits) and promotes myogenic differentiation via activation of p38MAPK (show MAPK14 ELISA Kits)
This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis.
Cdon homolog (mouse)
, surface glycoprotein, Ig superfamily member
, cell adhesion molecule-related/down-regulated by oncogenes
, Cdon homolog
, immunoglobulin superfamily member
, CAM-related/down-regulated by oncogenes
, immunoglobulin superfamily member CDO
, oncogene-regulated cell adhesion molecule
, cysteine dioxygenase type 1
, cysteine dioxygenase type I