Browse our anti-DDIT3 (DDIT3) Antibodies

Full name:
anti-DNA-Damage-Inducible Transcript 3 Antibodies (DDIT3)
On are 202 DNA-Damage-Inducible Transcript 3 (DDIT3) Antibodies from 25 different suppliers available. Additionally we are shipping DDIT3 Kits (32) and DDIT3 Proteins (19) and many more products for this protein. A total of 267 DDIT3 products are currently listed.
CEBPZ, CHOP, CHOP-10, Chop10, GADD153, Xchop
list all antibodies Gene Name GeneID UniProt
DDIT3 13198 P35639
DDIT3 29467  
DDIT3 1649 P35638

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Top referenced anti-DDIT3 Antibodies

  1. Human Monoclonal DDIT3 Primary Antibody for GS, ICC - ABIN269517 : Hull, Zraika, Udayasankar, Aston-Mourney, Subramanian, Kahn: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. in Diabetologia 2009 (PubMed)
    Show all 15 references for 269517

  2. Mouse (Murine) Polyclonal DDIT3 Primary Antibody for FACS, IF - ABIN655895 : Park, Choi, Yang, Do, Kim, Moon: Repression of peroxisome proliferator-activated receptor gamma by mucosal ribotoxic insult-activated CCAAT/enhancer-binding protein homologous protein. in Journal of immunology (Baltimore, Md. : 1950) 2010 (PubMed)
    Show all 3 references for 655895

  3. Human Polyclonal DDIT3 Primary Antibody for FACS, WB - ABIN656987 : Goodall, Wu, Zhang, McNeill, Ellis, Saudek, Gaston: Endoplasmic reticulum stress-induced transcription factor, CHOP, is crucial for dendritic cell IL-23 expression. in Proceedings of the National Academy of Sciences of the United States of America 2010 (PubMed)
    Show all 3 references for 656987

  4. Human Polyclonal DDIT3 Primary Antibody for IF, IHC - ABIN1531556 : Park, Luethy, Wang, Fargnoli, Fornace, McBride, Holbrook: Isolation, characterization and chromosomal localization of the human GADD153 gene. in Gene 1992 (PubMed)
    Show all 3 references for 1531556

  5. Human Polyclonal DDIT3 Primary Antibody for IF (p), IHC (p) - ABIN685447 : Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010 (PubMed)
    Show all 2 references for 685447

  6. Human Polyclonal DDIT3 Primary Antibody for IP, IHC - ABIN223141 : Zenkel, Kruse, Naumann, Schlötzer-Schrehardt: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. in Investigative ophthalmology & visual science 2007 (PubMed)

More Antibodies against DDIT3 Interaction Partners

Mouse (Murine) DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. SHP (show LAMC1 Antibodies) and REV-ERBalpha (show NR1D1 Antibodies) play a critical role in controlling rhythmic CHOP expression in alcoholic fatty liver

  2. ER stress-induced increase in ATF4 (show ATF4 Antibodies) and CHOP expression is initiated by an increase in Atf4 (show ATF4 Antibodies) and Chop mRNA, which is also dependent upon eIF2alpha (show EIF2A Antibodies) phosphorylation.

  3. Upregulating HSF1 (show HSF1 Antibodies) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP and increasing HSP70 (show HSP70 Antibodies) a5 (BiP/GRP78 (show HSPA5 Antibodies)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (show HSF1 Antibodies) being one likely key player in both systems.

  4. Study showed that Chop is involved in the pathogenesis of pulmonary fibrosis by regulating the generation of M2 macrophages and TGF-beta (show TGFB1 Antibodies) signaling.

  5. AMPKalpha1 (show PRKAA1 Antibodies) mediates CHOP ubiquitination and proteasomal degradation in macrophages by promoting the phosphorylation of CHOP at serine 30. Transfection of Chop-specific siRNA but not control siRNA reduced both CHOP level and injury-induced neointimal disruption in vivo.

  6. The data presented indicate that the unfolded protein response is activated in fibrotic lung tissue and strongly localized to macrophages. GRP78 (show HSPA5 Antibodies)- and CHOP-mediated macrophage apoptosis was found to protect against bleomycin-induced fibrosis.

  7. Deletion of CHOP attenuates dysfunction of the autophagy/lysosomal pathway in beta-cells of transgenic mice.

  8. Interference with DOT1L (show DOT1L Antibodies) activity resulted in transcriptional activation of Atf4 (show ATF4 Antibodies) and Ddit3 accompanied by decreased levels of H3K79 dimethylation.

  9. this study demonstrates novel roles for the endoplasmic reticulum stress-response transducer PERK (show EIF2AK3 Antibodies) and a downstream effector of its activation, CHOP, in tubule cell production of fibronectin (show FN1 Antibodies)

  10. CHOP regulates not only apoptosis-related signaling but also ROS (show ROS1 Antibodies) formation and inflammation in renal tubular cells during ischemia/reperfusion (I/R). CHOP may play an important role in the pathophysiology of I/R-induced renal injury.

Human DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. HDL (show HSD11B1 Antibodies) isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP upregulation, which were blocked by PBA and DPI (show DSP Antibodies). These data indicate that ox-HDL (show HSD11B1 Antibodies) may activate ER stress-CHOP-induced apoptotic pathway in macrophages via enhanced oxidative stress and that this pathway may be mediated by TLR4 (show TLR4 Antibodies).

  2. We found that 25-epi (show TFPI Antibodies) Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 (show HSPA5 Antibodies) expression, increased expression of the ER stress marker CHOP, loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B (show MAP1LC3B Antibodies).

  3. Western blot analysis of subcutaneously implanted AsPC-1 and BxPC-3 tumors as well as orthotopically implanted Panc-1 tumors demonstrated upregulation of BIP (show GDF10 Antibodies), CHOP, and IRE1alpha (show ERN1 Antibodies) expression in the tumor lysates from penfluridol-treated mice as compared to tumors from control mice

  4. CHOP protects hepatocytes from a diet high in fat, fructose, and cholesterol (HFCD) and its induced ER stress, and has a significant role in the mechanism of liraglutide-mediated protection against non-alcoholic steatohepatitis (NASH (show SAMSN1 Antibodies)) pathogenesis.

  5. Study showed that Chop is involved in the pathogenesis of pulmonary fibrosis by regulating the generation of M2 macrophages and TGF-beta (show TGFB1 Antibodies) signaling.

  6. Downregulation of CHOP by small interfering RNA somewhat restored expression of AR suggesting that AR degradation is dependent on ER stress pathway. Future studies will need to evaluate other aspects of the unfolded protein response pathway to characterize the regulation of AR degradation

  7. Herein, the authors extend their previous research and provide evidence that ORF57 of human herpesvirus-8 interacts with CHTOP (show CHTOP Antibodies) and CIP29 (show SARNP Antibodies), in contrast to POLDIP3 (show POLDIP3 Antibodies).

  8. NAG-1 (show GDF15 Antibodies) expression was transcriptionally upregulated by CHOP, which promoted chemokine (show CCL1 Antibodies) production through sustained NF-kappaB (show NFKB1 Antibodies) activation.

  9. plasma exposure resulted in expression of unfolded protein response (UPR) proteins such as glucoserelated protein 78 (GRP78 (show HSPA5 Antibodies)), protein kinase (show CDK7 Antibodies) R (PKR (show PKLR Antibodies))like ER kinase (PERK (show EIF2AK3 Antibodies)), and inositolrequiring enzyme 1 (IRE1 (show ERN1 Antibodies)). Elevated expression of spliced Xbox binding protein 1 (XBP1 (show XBP1 Antibodies)) and CCAAT/enhancerbinding protein homologous protein (CHOP) further confirmed that ROS (show ROS1 Antibodies) generatedby NTGP induces apoptosis through the ER stress

  10. High DDIT3 expression is associated with non-small-cell lung cancer.

Xenopus laevis DNA-Damage-Inducible Transcript 3 (DDIT3) interaction partners

  1. CHOP (GADD153) is an inhibitor of Wnt (show WNT2 Antibodies)/TCF (show HNF4A Antibodies) signals

DDIT3 Antigen Profile

Antigen Summary

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.

Alternative names and synonyms associated with DDIT3

  • DNA-damage-inducible transcript 3 (ddit3) antibody
  • DNA-damage inducible transcript 3 (Ddit3) antibody
  • DNA-damage-inducible transcript 3 (DDIT3) antibody
  • DNA-damage-inducible transcript 3 (Ddit3) antibody
  • DNA-damage-inducible transcript 3 (LOC100338439) antibody
  • CEBPZ antibody
  • CHOP antibody
  • CHOP-10 antibody
  • Chop10 antibody
  • GADD153 antibody
  • Xchop antibody

Protein level used designations for DDIT3

C/EBP homoologous protein 10 , C/EBP zeta , CCAAT/enhancer-binding protein homologous protein , DDIT-3 , DNA damage-inducible transcript 3 protein , c/EBP-homologous protein 10 , growth arrest and DNA-damage-inducible protein GADD153 , C/EBP homologous protein , growth arrest and DNA damage-inducible protein GADD153 , growth arrest and DNA damage-inducible , transcription factor GADD153 , C/EBP-homologous protein 10 , DNA-damage inducible transcript 3

733816 Xenopus (Silurana) tropicalis
13198 Mus musculus
29467 Rattus norvegicus
1649 Homo sapiens
398615 Xenopus laevis
777788 Bos taurus
607439 Canis lupus familiaris
100857832 Gallus gallus
101787388 Cavia porcellus
100240743 Sus scrofa
100338439 Oryctolagus cuniculus
541600 Ovis aries
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