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anti-Mouse (Murine) DDIT3 Antibodies:
anti-Rat (Rattus) DDIT3 Antibodies:
anti-Human DDIT3 Antibodies:
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Human Monoclonal DDIT3 Primary Antibody for GS, ICC - ABIN269517
Hull, Zraika, Udayasankar, Aston-Mourney, Subramanian, Kahn: Amyloid formation in human IAPP transgenic mouse islets and pancreas, and human pancreas, is not associated with endoplasmic reticulum stress. in Diabetologia 2009
Show all 15 Pubmed References
Human Polyclonal DDIT3 Primary Antibody for IHC, IHC (p) - ABIN4313145
Nashine, Liu, Kim, Clark, Pang: Role of C/EBP homologous protein in retinal ganglion cell death after ischemia/reperfusion injury. in Investigative ophthalmology & visual science 2015
Show all 6 Pubmed References
Mouse (Murine) Monoclonal DDIT3 Primary Antibody for IP, WB - ABIN2668558
Wang, Kuroda, Sok, Batchvarova, Kimmel, Chung, Zinszner, Ron: Identification of novel stress-induced genes downstream of chop. in The EMBO journal 1998
Show all 2 Pubmed References
Human Polyclonal DDIT3 Primary Antibody for IF (p), IHC (p) - ABIN685447
Du, Zhou, Jia, Huang: SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis. in Archives of biochemistry and biophysics 2010
Show all 2 Pubmed References
Human Polyclonal DDIT3 Primary Antibody for IP, IHC - ABIN223141
Zenkel, Kruse, Naumann, Schlötzer-Schrehardt: Impaired cytoprotective mechanisms in eyes with pseudoexfoliation syndrome/glaucoma. in Investigative ophthalmology & visual science 2007
Human Monoclonal DDIT3 Primary Antibody for ELISA, WB - ABIN560586
Kemmner, Kessel, Sanchez-Ruderisch, Möller, Hinderlich, Schlag, Detjen: Loss of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) induces apoptotic processes in pancreatic carcinoma cells. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2012
Human Polyclonal DDIT3 Primary Antibody for ELISA, WB - ABIN560585
Hong, Kim, Kim, Lee, Shin, Son, Han, Sung, Kwon: Apoptosis induction of 2'-hydroxycinnamaldehyde as a proteasome inhibitor is associated with ER stress and mitochondrial perturbation in cancer cells. in Biochemical pharmacology 2007
The study shows that FXR (show NR1H4 Antibodies)/RXR regulates Chop expression in a mouse model of steatohepatitis, providing novel insights into pathogenesis of this disorder.
Ddit3 suppresses the differentiation of ATDC5 cells
Free CNPY2 (show CNPY2 Antibodies) then engages protein kinase (show CDK7 Antibodies) R-like endoplasmic reticulum kinase (PERK (show EIF2AK3 Antibodies)) to induce expression of the transcription factor C/EBP homologous protein (CHOP), thereby initiating the unfolded protein response.
SHP (show LAMC1 Antibodies) and REV-ERBalpha (show NR1D1 Antibodies) play a critical role in controlling rhythmic CHOP expression in alcoholic fatty liver
ER stress-induced increase in ATF4 (show ATF4 Antibodies) and CHOP expression is initiated by an increase in Atf4 (show ATF4 Antibodies) and Chop mRNA, which is also dependent upon eIF2alpha (show EIF2A Antibodies) phosphorylation.
Upregulating HSF1 (show HSF1 Antibodies) relieves the tau toxicity in N2a-TauRD DeltaK280 by reducing CHOP and increasing HSP70 (show HSP70 Antibodies) a5 (BiP/GRP78 (show HSPA5 Antibodies)). Our work reveals how the bidirectional crosstalk between the two stress response systems promotes early tau pathology and identifies HSF1 (show HSF1 Antibodies) being one likely key player in both systems.
Study showed that Chop is involved in the pathogenesis of pulmonary fibrosis by regulating the generation of M2 macrophages and TGF-beta (show TGFB1 Antibodies) signaling.
AMPKalpha1 (show PRKAA1 Antibodies) mediates CHOP ubiquitination and proteasomal degradation in macrophages by promoting the phosphorylation of CHOP at serine 30. Transfection of Chop-specific siRNA but not control siRNA reduced both CHOP level and injury-induced neointimal disruption in vivo.
The data presented indicate that the unfolded protein response is activated in fibrotic lung tissue and strongly localized to macrophages. GRP78 (show HSPA5 Antibodies)- and CHOP-mediated macrophage apoptosis was found to protect against bleomycin-induced fibrosis.
Deletion of CHOP attenuates dysfunction of the autophagy/lysosomal pathway in beta-cells of transgenic mice.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK (show MAPK8 Antibodies), AP-1 (show FOSB Antibodies), and CHOP may interfere with complete autophagy.
The role of neutrophil elastase (show ELANE Antibodies) in the activation of unfolded protein response effector molecules via PERK (show EIF2AK3 Antibodies) and CHOP is reported.
The PERK (show EIF2AK3 Antibodies)-eIF2alpha (show EIF2A Antibodies)-ATF4 (show ATF4 Antibodies)-CHOP signaling pathway has a critical role in tumor progression during endoplasmic reticulum stress. (Review)
HDL (show HSD11B1 Antibodies) isolated from patients with metabolic syndrome induced macrophage apoptosis, oxidative stress, and CHOP upregulation, which were blocked by PBA and DPI (show DSP Antibodies). These data indicate that ox-HDL (show HSD11B1 Antibodies) may activate ER stress-CHOP-induced apoptotic pathway in macrophages via enhanced oxidative stress and that this pathway may be mediated by TLR4 (show TLR4 Antibodies).
We found that 25-epi (show TFPI Antibodies) Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 (show HSPA5 Antibodies) expression, increased expression of the ER stress marker CHOP, loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B (show MAP1LC3B Antibodies).
Western blot analysis of subcutaneously implanted AsPC-1 and BxPC-3 tumors as well as orthotopically implanted Panc-1 tumors demonstrated upregulation of BIP (show GDF10 Antibodies), CHOP, and IRE1alpha (show ERN1 Antibodies) expression in the tumor lysates from penfluridol-treated mice as compared to tumors from control mice
CHOP protects hepatocytes from a diet high in fat, fructose, and cholesterol (HFCD) and its induced ER stress, and has a significant role in the mechanism of liraglutide-mediated protection against non-alcoholic steatohepatitis (NASH (show SAMSN1 Antibodies)) pathogenesis.
Downregulation of CHOP by small interfering RNA somewhat restored expression of AR suggesting that AR degradation is dependent on ER stress pathway. Future studies will need to evaluate other aspects of the unfolded protein response pathway to characterize the regulation of AR degradation
Herein, the authors extend their previous research and provide evidence that ORF57 of human herpesvirus-8 interacts with CHTOP (show CHTOP Antibodies) and CIP29 (show SARNP Antibodies), in contrast to POLDIP3 (show POLDIP3 Antibodies).
CHOP (GADD153) is an inhibitor of Wnt (show WNT2 Antibodies)/TCF (show HNF4A Antibodies) signals
This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified.
C/EBP homoologous protein 10
, C/EBP zeta
, CCAAT/enhancer-binding protein homologous protein
, DNA damage-inducible transcript 3 protein
, c/EBP-homologous protein 10
, growth arrest and DNA-damage-inducible protein GADD153
, C/EBP homologous protein
, growth arrest and DNA damage-inducible protein GADD153
, growth arrest and DNA damage-inducible
, transcription factor GADD153
, C/EBP-homologous protein 10
, DNA-damage inducible transcript 3