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Mammalian Monoclonal DLG4 Primary Antibody for ISt, IHC - ABIN1304919
Higuchi, Macke, Lee, Miller, Xu, Ikeda, Ikeda: Genetic basis of age-dependent synaptic abnormalities in the retina. in Mammalian genome : official journal of the International Mammalian Genome Society 2015
Show all 336 Pubmed References
Human Monoclonal DLG4 Primary Antibody for BP, ChIP - ABIN4348100
Fogel, Akins, Krupp, Stagi, Stein, Biederer: SynCAMs organize synapses through heterophilic adhesion. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Show all 11 Pubmed References
Human Polyclonal DLG4 Primary Antibody for IP, WB - ABIN1742271
Li, Hu, Höfer, Wong, Cooper, Birnbaum, Hammer, Hofmann: DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory. in The Journal of biological chemistry 2010
Show all 9 Pubmed References
Mouse (Murine) Monoclonal DLG4 Primary Antibody for IF, IP - ABIN968003
Brenman, Chao, Gee, McGee, Craven, Santillano, Wu, Huang, Xia, Peters, Froehner, Bredt: Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains. in Cell 1996
Show all 5 Pubmed References
Mouse (Murine) Monoclonal DLG4 Primary Antibody for IF, IP - ABIN968002
Cho, Hunt, Kennedy: The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. in Neuron 1992
Show all 5 Pubmed References
Human Polyclonal DLG4 Primary Antibody for IF (p), IHC (p) - ABIN725930
Zhao, Li, Wei, Savage, Zhou, Ma: Ketamine administered to pregnant rats in the second trimester causes long-lasting behavioral disorders in offspring. in Neurobiology of disease 2014
Show all 4 Pubmed References
Human Polyclonal DLG4 Primary Antibody for ELISA, IHC - ABIN1585109
Wessel, Balakrishnan-Renuka, Henkel, Meyer, Meller, Brand-Saberi, Theiss: Long-term incubation with mifepristone (MLTI) increases the spine density in developing Purkinje cells: new insights into progesterone receptor mechanisms. in Cellular and molecular life sciences : CMLS 2014
Show all 2 Pubmed References
Mouse (Murine) Polyclonal DLG4 Primary Antibody for WB - ABIN152631
Reissner, Boyle, Ye, Carew: Aplysia synapse associated protein (APSAP): identification, characterization, and selective interactions with Shaker-type potassium channels. in Journal of neurochemistry 2008
Mammalian Monoclonal DLG4 Primary Antibody for ISt, IHC - ABIN1304920
Gonzalez-Lozano, Klemmer, Gebuis, Hassan, van Nierop, van Kesteren, Smit, Li: Dynamics of the mouse brain cortical synaptic proteome during postnatal brain development. in Scientific reports 2016
Human Polyclonal DLG4 Primary Antibody for IHC, IHC (p) - ABIN4348101
Fourie, Kim, Waldvogel, Wong, McGregor, Faull, Montgomery: Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington's Disease and Parkinson's Disease Human Brains. in Journal of neurodegenerative diseases 2015
Exon junction complex (EJC) activity is indispensable for Wg signaling by maintaining an appropriate level of Dsh (show DVL2 Antibodies) protein for Wg ligand reception in Drosophila. Genetic and biochemical experiments demonstrate that Dlg1 protein acts independently from its role in cell polarity to protect Dsh (show DVL2 Antibodies) protein from lysosomal degradation.
Banderuola (Bnd) is a novel regulator of asymmetric cell division (ACD (show ACD Antibodies)). The data place Bnd at the top of the hierarchy of the factors involved in ACD (show ACD Antibodies), suggesting that its main function is mediating localization and function of Dlg tumor suppressor.
The inactivation of cellular cortex polarization is the most likely target of dlg inactivation in mitosis.
Loss of scrib (show SCRIB Antibodies), dlg and lgl had no effect on gonad formation, but Dlg and Scrib (show SCRIB Antibodies) in the gonadal mesoderm acted critically in the somatic wrapping of the pole cells and the internal structure of the Drosophila embryonic gonads.
Gliotactin and Discs large are co-regulated to maintain epithelial integrity.
Hts (show APCDD1 Antibodies) regulates Dlg targeting to the neuromuscular junction in muscle and the lateral membrane of epithelial cells.
Electron microscopy reveals that during metamorphosis the subsynaptic reticulum vacuolizes in the early stages of synapse dismantling, concomitant with diffuse localization of Dlg.
DlgS97-Metro-DLin-7-type complexes control the proper organization of a synaptic junction; findings accentuate the importance of perisynaptic scaffold complexes for synaptic stabilization and organization
Study provide evidence that scrib (show SCRIB Antibodies) and dlg function differentially in anterior and posterior patterning of the follicular epithelium at oogenesis. Further genetic analysis indicates that scrib (show SCRIB Antibodies) and dlg act in a common pathway to regulate PFC (show CFP Antibodies) fate induction.
integrins act through CaMKII (show CAMK2 Antibodies) activation to control the localization of dlg in the development of NMJ synaptic morphology
This study demonstrated that in Chronic social defeat stress leads to changes PSD-95 in hippocampus of young mice.
The authors present evidence that synGAP (show SYNGAP1 Antibodies)-alpha1 regulates the composition of the postsynaptic density by restricting binding to the PDZ (show INADL Antibodies) domains of PSD-95.
In Fmr1 (show FMR1 Antibodies) KO neurons, Mdm2 (show MDM2 Antibodies) is hyperphosphorylated, nuclear localized basally, and unaffected by MEF2 (show MEF2C Antibodies) activation, which our data suggest due to an enhanced interaction with Eukaryotic Elongation Factor (show TSFM Antibodies) 1alpha (EF1alpha), whose protein levels are elevated in Fmr1 (show FMR1 Antibodies) KO. Expression of a dephosphomimetic of Mdm2 (show MDM2 Antibodies) rescues PSD-95 ubiquitination, degradation and synapse elimination in Fmr1 (show FMR1 Antibodies) KO neurons.
tested the effect of five targeted mouse mutations on the assembly of known PSD95 interactors, Kir2.3 (show KCNJ4 Antibodies), Arc (show NOL3 Antibodies), IQsec2/BRAG1 (show IQSEC2 Antibodies) and Adam22 (show ADAM22 Antibodies)
Therefore, our study suggests that CREB and PSD95 are novel substrates of PERK, so inhibition of PERK phosphorylation using GSK2656157 would be beneficial against memory impairment after TBI.
PSD95 and SYP (show PTPN11 Antibodies) may originate from the different sites, but they are closely related to the formation and maturation of synapse.
Expression levels of brain derived neurotrophic factor, postsynaptic density 95, and p-cyclic-AMP response element binding protein levels were significantly elevated in the testosterone (T) group, but flutamide reduced the T-induced effects in these biomarkers to control levels.
The results suggest that the neurological mechanisms of chronic stress on cognition might be associated with a decrease in hippocampal SYN (show SYP Antibodies) and PSD95 expression, which is critical for structural synaptic plasticity.
critical roles of PSD-95 in regulating synaptic kainate receptors.
Phenylketonuric mice given a specific nutrient combination showed a significant reduction in PSD-95 expression in the hippocampus, specifically in the granular cell layer of the dentate gyrus, with a similar trend seen in the cornus ammonis 1 (CA1 (show CA1 Antibodies)) and cornus ammonis 3 (CA3 (show CA3 Antibodies)) pyramidal cell layer.
Phosphorylation at Y397 induced a significant increase in affinity for stargazing. The strategy presented here to generate site-specifically phosphorylated PDZ (show INADL Antibodies) domains provides a detailed understanding of the role of phosphorylation in the regulation of PSD95 interactions.
This study demonstrated that a significant decrease in the protein level of PSD-95 in major depression disorder.
These results indicate that PKC (show PRRT2 Antibodies) promotes synaptogenesis by activating PSD-95 phosphorylation directly through JNK1 (show MAPK8 Antibodies) and calcium/calmodulin-dependent kinase (show CAMK2 Antibodies) II and also by inducing expression of PSD-95 and synaptophysin (show SYP Antibodies).
The differences in cortical NMDAR (show GRIN1 Antibodies) expression and post-synaptic density protein 95 are present in psychiatric disorders and suicide completion and may contribute to different responses to ketamine.
Mutation C>T at the rs13331 in the PSD95 gene is strikingly associated with an increased risk of autism spectrum disorders.
Data demonstrate a role for SNAP-25 (show SNAP25 Antibodies) in controlling PSD-95 clustering and open the possibility that genetic reductions of the protein levels may contribute to the pathology through an effect on postsynaptic function and plasticity.
Data indicate the very high affinities of the trimeric ligands to postsynaptic density protein 95 (PSD-95) PDZ (show INADL Antibodies) domains.
In this review, we focus on palmitoylation of PSD-95, which is a major postsynaptic scaffolding protein and makes discrete postsynaptic nanodomains in a palmitoylation-dependent manner and discuss a determinant role of local palmitoylation cycles
An association was found between reduced PSD95 in the prefrontal cortex and cognitive impairment in patients with either dementia with Lewy bodies or Parkinson's disease dementia.
Docosahexaenoic acid-containing phosphatidylcholines and PSD-95 decrease after loss of synaptophysin (show SYP Antibodies) and before neuronal loss in patients with Alzheimer's disease.
This gene encodes a member of the membrane-associated guanylate kinase (MAGUK) family. It heteromultimerizes with another MAGUK protein, DLG2, and is recruited into NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Multiple transcript variants encoding different isoforms have been found for this gene.
, disc large
, discs large
, disk large
, lethal(1)benign wing imaginal disc neoplasm
, lethal(1)discs large
, lethal(2)discs large
, discs, large homolog 4
, postsynaptic density protein 95
, disks large homolog 4
, PSD-95 alpha 2b
, PSD-95 beta
, discs large homolog 4
, synapse-associated protein 90
, synapse-associated protein SAP90
, Tax interaction protein 15
, post-synaptic density protein 95