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Epigenetic factor EPC1 (show SERPINF1 Proteins) is a master regulator of DNA damage response by interacting with E2F1 (show E2F1 Proteins) to silence death and activate metastasis-related gene signatures
Silencing EPC1 (show SERPINF1 Proteins) by short hairpin RNA technology had the inhibition effects on cell proliferation and tumor growth in lung cancer
EPC1 (show SERPINF1 Proteins) and EPC2 are components of a complex that directly or indirectly serves to prevent MYC (show MYC Proteins) accumulation and AML (show RUNX1 Proteins) cell apoptosis, thus sustaining oncogenic potential
Epc1 (show SERPINF1 Proteins) plays a role in the initiation of skeletal muscle differentiation, and its interaction with Hop (show STIP1 Proteins) is required for the full activity.
SNP array CGH analysis of the breakpoint region in 3 ATLL-related cell lines and 4 patient samples revealed the chromosomal breakpoints are localized within the EPC1 (show SERPINF1 Proteins) gene locus in an ATLL-derived cell line (SO4) and in one patient with acute-type ATLL.
results indicate that Epc1 induces vascular smooth muscle differentiation by interacting with myocardin to induce serum response factor-dependent smooth muscle genes; propose that Epc1 acts as a novel negative regulator of neointima formation after carotid injury
Epc1-induced enhancements of SRF-dependent multinucleation, transactivation of the skeletal alpha-actin (show ACTA1 Proteins) promoter, binding of SRF to the serum response element, and muscle-specific (show EIF3K Proteins) gene induction were blocked by RFP (show RFP Proteins).
showed that E2F6 (show E2F6 Proteins), DP1 (show REEP5 Proteins), EPC1, EZH2 (show EZH2 Proteins), and Sin3B (show SIN3B Proteins) co-elute, suggesting the identification of a novel E2F6 (show E2F6 Proteins) complex that exists in vivo in both normal and transformed human cell lines
Epc1 plays a role in the initiation of skeletal muscle differentiation, and its interaction with Hop (show STIP1 Proteins) is required for the full activity.
Epc1 is required for skeletal muscle differentiation by recruiting both SRF and p300 (show NOTCH1 Proteins) to the SRE of muscle-specific (show EIF3K Proteins) gene promoters
This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, gene silencing, and adult T-cell leukemia/lymphoma. Alternative splicing results in multiple transcript variants.
enhancer of polycomb homolog 1 (Drosophila)
, enhancer of polycomb 1
, enhancer of polycomb homolog 1
, enhancer of polycomb homolog 1-like