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myocardin is an essential component of the regulatory pathway for myocardial differentiation
several transcription factors, that is SRF, myocardin, and GATA6, that induce the expression of SM-MHC in animal cap cells
Study demonstrates that myocardin indirectly down-regulates Cx43 (show GJA1 Antibodies) through its repressive action on miR (show MLXIP Antibodies)-206 to regulate vascular smooth muscle cell phenotypic switch.
These results have revealed the roles for atrogin-1 (show FBXO32 Antibodies) in the regulation of smooth muscle contractility through enhancement of myocardin ubiquitylation/degradation and its transcriptional activity.
our study reveals that Ang II (show AGT Antibodies) downregulates miR (show MLXIP Antibodies)-145 to regulate Klf4 (show KLF4 Antibodies) and myocardin expression in HCASMCs under high glucose conditions. Ang II (show AGT Antibodies) plays a critical role in the regulation of miR (show MLXIP Antibodies)-145 under hyperglycemic conditions
Human expression data disclosed correlations of MYOCD with CAV1 in a majority of human tissues and in the heart, correlation with MKL2 (MRTF-B) was observed.
inhibition of GSK-3beta (show GSK3b Antibodies) reduces myocardin transcriptional activity, suggesting a role for GSK-3beta (show GSK3b Antibodies) in myocardin transcriptional activity and smooth muscle differentiation
STAT3 protein regulates vascular smooth muscle cell phenotypic switch by interaction with myocardin and SRF.
TMEM16A (show ANO1 Antibodies) and myocardin form a positive feedback loop that is disrupted by KLF5 (show KLF5 Antibodies) during Ang II (show AGT Antibodies)-induced vascular remodeling.
TNFalpha (show TNF Antibodies) differentially regulates myocardin expression and activity
Propose myocardin as a guardian of the contractile, noninflammatory VSMC phenotype, with loss of myocardin representing a critical permissive step in the process of phenotypic transition and inflammatory activation, at the onset of vascular disease.
it is probably that miR135b promotes proliferation, invasion and migration of osteosarcoma cells by degrading myocardin
Knock down of the serum response factor (SRF), which mediates many of the effects of myocardin, decreased cavin-1 but increased caveolin-1 and -2 mRNAs.
Cholesterol loading of vascular smooth muscle cells converts them to a macrophage-appearing state by downregulating the miR (show MLXIP Antibodies)-143/145-myocardin axis.
Our data illustrate a novel mechanism that connects MRTF-A (show MKL1 Antibodies) dependent histone H3K4 methylation to HSC (show FUT1 Antibodies) activation.
DKK3 induces stem cell differentiation into smooth muscle lineage via ATF6 (show ATF6 Antibodies) signaling and myocardin expression.
Myocardin has a critical role in maintenance of vascular and visceral smooth muscle homeostasis during postnatal development
Foxf2 (show FOXF2 Antibodies) attenuated myocardin/serum response factor signaling in smooth muscle cells through direct binding to the N-terminal region of myocardin
The authors describe the of a Cre knock-in into the Myocardin locus and show that Myocardin expression marks the earliest cardiac and smooth muscle lineages.
a moderate inhibition (e.g., normalization) of the activated MYOCD signaling in the diseased heart may be promising from a therapeutic point of view
MYOCD DeltaExon 11 may participate in modulating smooth muscle cell phenotype, potentially acting as a dominant-negative repressor of contraction-related genes.
Data show that forced myocd-A expression in the LVFW caused abnormal ECG.
Thrombin (show F2 Antibodies) stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1 (show F2R Antibodies), RhoA (show RHOA Antibodies), and myocardin.
This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, SRF co-factor protein (cardiac and smooth muscle)
, SRF cofactor protein
, basic SAP coiled-coil transcription activator 2
, transcription factor myocardin