Browse our Cytochrome B-245, alpha Polypeptide Proteins (CYBA)

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Cytochrome B-245, alpha Polypeptide Proteins (CYBA)
On are 8 Cytochrome B-245, alpha Polypeptide (CYBA) Proteins from 3 different suppliers available. Additionally we are shipping Cytochrome B-245, alpha Polypeptide Antibodies (49) and many more products for this protein. A total of 62 Cytochrome B-245, alpha Polypeptide products are currently listed.
b558, CYBA, MGC80750, nmf333, P22-PHOX, p22phox, zgc:66077
list all proteins Gene Name GeneID UniProt
CYBA 1535 P13498
CYBA 13057 Q61462
Rat CYBA CYBA 79129 Q62737

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Cytochrome B-245, alpha Polypeptide Proteins (CYBA) by Origin

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More Proteins for Cytochrome B-245, alpha Polypeptide Interaction Partners

Human Cytochrome B-245, alpha Polypeptide (CYBA) interaction partners

  1. PI3K (show PIK3CA Proteins)/AKT (show AKT1 Proteins) signaling only occurs when FLT3 (show FLT3 Proteins)-ITD is expressed at the plasma membrane and is required for the production of NOX-generated ROS (show ROS1 Proteins). ER retention of FLT3 (show FLT3 Proteins)-ITD resulted in NOX4 (show NOX4 Proteins) deglycosylation and p22(phox) protein degradation.

  2. CYBA gene ()49A>G polymorphism modifies the risk of coronary artery disease

  3. The study demonstrated that the genetic variants of rs9932581 and rs1049255 in CYBA might not be associated with preeclampsia.

  4. p22phox C242T polymorphism has a possible role in changing the genetic susceptibility to late-onset AD in ApoE 4 carriers of northern Han Chinese origin.

  5. CYBA mutations lead to one of the autosomal recessive forms of chronic granulomatous disease (AR220CGD) clinically characterized by recurrent and severe infections in early chilA large number of genetic variations of CYBA have been reported, among them the C242T polymorphism, which has been extensively studied in association with coronary artery and heart diseases, but conflicting results continue to be reported. [Review]

  6. C242T single-nucleotide polymorphism causes p22(phox) structural changes that inhibit endothelial Nox2 (show CYBB Proteins) activation and oxidative response to tumor necrosis factor-alpha (show TNF Proteins) or high-glucose stimulation. C242T single-nucleotide polymorphism may represent a natural protective mechanism against inflammatory cardiovascular diseases.

  7. CYBA C242T correlates with microalbuminuria onset in the French DT1 cohort.

  8. Overexpression of p22phox is associated with increased migration/metastasis rate in melanoma.

  9. To evaluate the association between CYBA gene polymorphisms and ESRD, we genotyped five CYBA polymorphisms. Our results suggested that rs1049255 polymorphism of CYBA modified the risk of ESRD.

  10. Substance P (show TAC1 Proteins) enhances tissue factor (show F3 Proteins) release from granulocyte-macrophage colony-stimulating factor (show CSF2 Proteins)-dependent macrophages via the p22phox/beta-arrestin 2 (show ARRB2 Proteins)/Rho A (show RHOA Proteins) signaling pathway.

Mouse (Murine) Cytochrome B-245, alpha Polypeptide (CYBA) interaction partners

  1. p22phox mRNA expression was increased in diet-induced obese (DIO) mice.

  2. The present study provides evidence that augmented EGFRtk impairs vascular function by NADPH oxidase (show NOX1 Proteins)-dependent mechanism. Therefore, EGFRtk and oxidative stress should be potential targets to treat vascular dysfunction in TD2.

  3. Vascular hnRNP-C (show HNRNPC Proteins) expression is regulated by ROS (show ROS1 Proteins) derived from NADPH (show FDXR Proteins) oxidases and that the effects of NADPH oxidase (show NOX1 Proteins) on vascular activation are mediated in part by protein kinase (show CDK7 Proteins) CK1alpha (show CSNK1A1 Proteins).

  4. Enhanced p22(phox) expression causes vascular dysfunction through ERK1/2 and p38-mitogen-activated protein kinase (show MAPK14 Proteins)-dependent mechanisms in male type 2 diabetic mice.

  5. The first quantitative characterization of the interactions made between the cytosolic regulators NOXO1 (show NOXO1 Proteins) and NOXA1 (show NOXA1 Proteins) and membrane-bound p22(phox), is presented.

  6. renal expression of Nox-2 (show CYBB Proteins), p22(phox), and p47(phox), components of NADPH oxidase (show NOX1 Proteins), are upregulated in GSD-Ia mice compared with controls

  7. cytochrome b558 expression is downregulated via the reduction of heme availability after NADPH oxidase (show NOX1 Proteins) is inhibited by HO-1 (show HMOX1 Proteins)

  8. LPS (show TLR4 Proteins) treatment enhanced protein levels of p22(phox), a catalytic subunit of NADPH oxidase (show NOX1 Proteins), and increased NADPH oxidase (show NOX1 Proteins) activity and levels of superoxide radicals and hydrogen peroxide.

  9. p22phox expression was increased during glucose-induced oxidative stress in microvascular endothelial cells.

  10. collagen synthesis in cardiac fibroblasts involves a facilitative interaction between TGFbeta (show TGFB1 Proteins)(1)-NADPH oxidase (show NOX1 Proteins) and LOX-1 (show OLR1 Proteins)

Pig (Porcine) Cytochrome B-245, alpha Polypeptide (CYBA) interaction partners

  1. Upregulation of PPAR-gamma (show PPARG Proteins) and NADPH (show NQO1 Proteins) oxidases are involved in restenosis.

  2. CRP (show CRP Proteins) inhibits endothelium-dependent NO-mediated dilation in coronary arterioles by producing superoxide from NAD(P)H (show NQO1 Proteins) oxidase via p38 (show MAPK14 Proteins) kinase activation

  3. Reactive oxygen species generated by NADPH oxidase (show NOX1 Proteins) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.

Rabbit Cytochrome B-245, alpha Polypeptide (CYBA) interaction partners

  1. Angiotensin II inhibits the Na+/K+ pump via protein kinase c epsilon (show PRKCE Proteins)-dependent activation of NADPH oxidase (show NOX1 Proteins) subunits.

Cytochrome B-245, alpha Polypeptide (CYBA) Protein Profile

Protein Summary

Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells.

Alternative names and synonyms associated with Cytochrome B-245, alpha Polypeptide (CYBA)

  • cytochrome b-245, alpha polypeptide (cyba)
  • cytochrome b-245, alpha polypeptide (CYBA)
  • cytochrome b-245 light chain-like (LOC101328418)
  • cytochrome b-245, alpha polypeptide (Cyba)
  • p22-phox (CYBA)
  • b558 protein
  • CYBA protein
  • MGC80750 protein
  • nmf333 protein
  • P22-PHOX protein
  • p22phox protein
  • zgc:66077 protein

Protein level used designations for CYBA

P22phox , cytochrome b-245, alpha polypeptide , predicted cytochrome b-245, alpha polypeptide , Cytochrome b(558) alpha chain , Cytochrome b558 subunit alpha , Neutrophil cytochrome b 22 kDa polypeptide , Superoxide-generating NADPH oxidase light chain subunit , cytochrome b-245 light chain , flavocytochrome b558 (p22phox) , p22 phagocyte B-cytochrome , cytochrome b light chain , cytochrome b(558) alpha chain , cytochrome b(558) alpha-subunit , cytochrome b, alpha polypeptide , cytochrome b558 subunit alpha , flavocytochrome b-558 alpha polypeptide , neutrophil cytochrome b 22 kDa polypeptide , p22phox , superoxide-generating NADPH oxidase light chain subunit , cytochrome beta-558 , p22 phox , p22-phox , cytochrome b558 alpha-subunit , NADPH oxidase light chain subunit

393551 Danio rerio
446853 Xenopus laevis
489664 Canis lupus familiaris
549234 Xenopus (Silurana) tropicalis
100135693 Ovis aries
101328418 Tursiops truncatus
1535 Homo sapiens
13057 Mus musculus
79129 Rattus norvegicus
281111 Bos taurus
397507 Sus scrofa
100008800 Oryctolagus cuniculus
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