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SPR-mediated reduction of sepiapterin and redox cycling occur by distinct mechanisms
biopterin contents in the brains of these knock-out mice were moderately decreased from postnatal day 0 (P0) and remained constant up to P21
These data suggest an essential role of SPR in the biosynthesis of BH4, and that the SPR gene could be a candidate gene for PARK3.
High Truncated Neurokinin-1 Receptor expression is associated with Neuroblastoma (show ARHGEF16 ELISA Kits).
Abnormalities in substance P neurokinin-1 (show TAC1 ELISA Kits) receptor binding in key brainstem nuclei is associated with sudden infant death syndrome.
TGF-beta1 (show TGFB1 ELISA Kits) down-regulates the gene expression of the full-length variant of NK-1 (show CD160 ELISA Kits) R in human keratocytes, which might impact its signaling pathway and thus explain the known delay in internalization after activation by SP seen with TGF-beta1 (show TGFB1 ELISA Kits) treatment.
Expression substance P/neurokinin A (show TAC1 ELISA Kits)/hemokinin-1 and their preferred neurokinin 1/neurokinin 2 (show TAC1 ELISA Kits) receptors are dysregulated in uterine leiomyomata.
results suggest that ARRB1 (show ARRB1 ELISA Kits) plays an essential role in NK1R (show TACR1 ELISA Kits)-mediated cell proliferation and G2/M transition in glioblastoma cells. Interference with ARRB1 (show ARRB1 ELISA Kits)-mediated signaling via NK1R (show TACR1 ELISA Kits) may have potential significance for therapeutic strategies targeting glioblastoma.
The allele frequencies for the SPR c.596-2A > G (0.7%) polymorphism is not a major cause of Parkinson's disease in the Maltese.
Data suggest that endogenous tachykinin ligands for neurokinin-1 receptor exhibit large variations in binding/activation kinetics; substance P (show TAC1 ELISA Kits) exhibits fast association kinetics; neurokinin A (show TAC1 ELISA Kits) exhibits slow association kinetics.
We showed that pretreating a cardiomyocyte cell line (H9C2) and a TNBC cell line (MDA-MB 231) with aprepitant, a SP receptor antagonist that is routinely used to treat chemotherapy-associated nausea, decreased DOX-induced reduction of viability, apoptotic cell death, and ROS (show ROS1 ELISA Kits) production in cardiomyocytes
These findings reveal important insight into the molecular mechanisms of the NK1R (show TACR1 ELISA Kits) complex as a critical component in a model of pediatric liver cancer and may support the development of novel therapeutic interventions for hepatoblastoma
Neuropeptide signaling through neurokinin-1 (show TAC1 ELISA Kits) and neurokinin-2 (show TAC1 ELISA Kits) receptors augments antigen presentation by human dendritic cells
this study demonstrates an important role of endothelial SPR in modulating tetrahydrobiopterin and nitric oxide bioavailability
This gene belongs to a gene family of tachykinin receptors. These tachykinin receptors are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin substance P, also referred to as neurokinin 1. The encoded protein is also involved in the mediation of phosphatidylinositol metabolism of substance P.
, Sepiapterin reductase
, short chain dehydrogenase/reductase family 38C, member 1
, 7,8-dihydrobiopterin:NADP+ oxidoreductase
, NK-1 receptor
, substance-P receptor
, tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)
, neurokinin 1 receptor
, substance p receptor