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An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.
Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription
These data indicate that, through cooperation with PolII and KDM6A, Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.
site-specific p65 phosphorylation targets NF-kappaB activity to particular gene subsets on a global level by influencing p65 and p-RNAP II promoter recruitment
Data show that that B2 RNA, when present with Pol II in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH (show GTF2H4 Proteins).
investigation of contribution of largest subunit of phosphorylated RNAP II to onset of minor gene activation in zygote; nuclear localization of RNAP II in 1-cell zygote; regulation of RNAP II expression by deposition of acetylated histone on promoter
involvement of RPB1, the largest subunit of RNA polymerase II (RNAP II), in the regulation of transcriptional silencing mechanism
Reduction in RNA Pol II (show POLR2F Proteins) association is indicative of interruption in direct interactions of RNA Pol II (show POLR2F Proteins) with PEPCK (show PEPCK Proteins) promoter, with general transcription factors and/or with coregulator molecules contributeing to activation of PEPCK (show PEPCK Proteins) gene.
These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.[Rpb1]
Results suggest that RNA polymerase II is selectively required for positive transcriptional regulation of a subset of genes in embryonic stem cells.
Rpb1/2 dynamics help govern the decision between sense and divergent antisense transcription.
The results showed heterogeneity in the responses of individual KSHV episomes to stimuli within a single reactivating cell; those episomes that did respond to stimulation, aggregated within large domains that appear to function as viral transcription factories. A significant portion of cellular RNA polymerase II was trapped in these factories and served to transcribe viral genomes.
The authors show here that glutamine deprivation suppresses translation of endogenous MYC via coupling the 3'-UTR of the MYC mRNA and RNA polymerase II function.
Data show that inhibition of VCP/p97, or siRNA-mediated ablation of VCP/p97 impairs ultraviolet radiation (UVR)-induced RNA polymerase II (RNAPII) degradation.
Role of chromatin-bound EGFR and ERK kinases in RNA polymerase 2 transcription
recurrent somatic mutations in POLR2A hijack this essential enzyme and drive meningioma neoplasia
the Elongin A ubiquitin ligase and the CSB protein function together in a common pathway in response to Pol II stalling and DNA damage
By studying global gene expression patterns and genome-wide DNA-binding patterns of CGGBP1 (show CGGBP1 Proteins), it has been shown that a possible mechanism through which it affects the expression of RNA Pol II-transcribed genes in trans depends on Alu RNA.
Using a 7,781-sample pan-cancer dataset, we first confirmed this in POLR2A are known to confer elevated sensitivity to pharmacological suppression.hese include the POLR2A interacting protein INTS10 (show INTS10 Proteins) as well as genes involved in mRNA splicing, nonsense-mediated mRNA
HIV Tat precisely controls RNA polymerase II recruitment and pause release to fine-tune the initiation and elongation steps in target genes.
This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.
DNA-directed RNA polymerase II subunit RPB1
, polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
, 220 kDa DNA-directed RNA polymerase polypeptide A
, DNA-directed RNA polymerase II largest subunit
, RNA polymerase II polypeptide A
, DNA-directed RNA polymerase II A
, DNA-directed RNA polymerase II subunit A
, DNA-directed RNA polymerase III largest subunit
, RNA polymerase II 1
, RNA polymerase II subunit B1
, Polymerase (RNA II (DNA directed), large polypeptide
, DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit
, RNA-directed RNA polymerase II subunit RPB1
, polymerase (RNA) II (DNA directed) polypeptide A (220kD)