You are viewing an incomplete version of our website. Please click to reload the website as full version.

Browse our POLR2A Proteins (POLR2A)

Full name:
Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa Proteins (POLR2A)
On www.antibodies-online.com are 2 Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa (POLR2A) Proteins from 2 different suppliers available. Additionally we are shipping POLR2A Antibodies (56) and POLR2A Kits (6) and many more products for this protein. A total of 65 POLR2A products are currently listed.
Synonyms:
19.m02399, 220kDa, hRPB220, hsRPB1, NCU02103.1, POLR2, POLR2A, POLRA, RPB1, RPBh1, RpIILS, RPO2, Rpo2-1, RPOL2
list all proteins Gene Name GeneID UniProt
Mouse POLR2A POLR2A 20020 P08775
Rat POLR2A POLR2A 363633  
POLR2A 5430 P24928

Show all synonyms

POLR2A Proteins (POLR2A) by Origin

Select your origin of interest

More Proteins for POLR2A Interaction Partners

Mouse (Murine) Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa (POLR2A) interaction partners

  1. An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation.

  2. Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

  3. These data indicate that, through cooperation with PolII and KDM6A, Spt6 orchestrates removal of H3K27me3, thus controlling developmental gene expression and cell differentiation.

  4. site-specific p65 phosphorylation targets NF-kappaB activity to particular gene subsets on a global level by influencing p65 and p-RNAP II promoter recruitment

  5. Data show that that B2 RNA, when present with Pol II in promoter-bound complexes, specifically represses CTD phosphorylation by TFIIH (show GTF2H4 Proteins).

  6. investigation of contribution of largest subunit of phosphorylated RNAP II to onset of minor gene activation in zygote; nuclear localization of RNAP II in 1-cell zygote; regulation of RNAP II expression by deposition of acetylated histone on promoter

  7. involvement of RPB1, the largest subunit of RNA polymerase II (RNAP II), in the regulation of transcriptional silencing mechanism

  8. Reduction in RNA Pol II (show POLR2F Proteins) association is indicative of interruption in direct interactions of RNA Pol II (show POLR2F Proteins) with PEPCK (show PEPCK Proteins) promoter, with general transcription factors and/or with coregulator molecules contributeing to activation of PEPCK (show PEPCK Proteins) gene.

  9. These results indicate that Wwp2 plays an important role in regulating expression of Rpb1 in normal physiological conditions.[Rpb1]

  10. Results suggest that RNA polymerase II is selectively required for positive transcriptional regulation of a subset of genes in embryonic stem cells.

Human Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa (POLR2A) interaction partners

  1. HIV Tat precisely controls RNA polymerase II recruitment and pause release to fine-tune the initiation and elongation steps in target genes.

  2. TOP1 bound at promoters was discovered to become fully active only after pause-release. This transition coupled the phosphorylation of the carboxyl-terminal-domain (CTD) of RNA polymerase II (RNAPII) with stimulation of TOP1 above its basal rate, enhancing its processivity.

  3. Its variant is not related to sporadic PD in Chinese Han population.

  4. Data suggest RNA polymerase II (POLR2A) is extensively modified on its unique C-terminal domain (CTD) by O-GlcNAc (show OGT Proteins) transferase (OGT (show OGT Proteins)); efficient O-GlcNAcylation requires a minimum of 20 heptad CTD repeats in POLR2A and more than half of NTD of OGT (show OGT Proteins).

  5. Serine phosphorylation stimulates whereas tyrosine phosphorylation inhibits the protein-binding activity of the RNA Pol II C-terminal domain.

  6. The amount of RNA polymerase II (RNAPII) on the HIV promoter and other viral regions was strongly diminished in HIV-infected CD4+ cells co-cultivated with cell non-cytotoxic antiviral response-expressing CD8+ cells.

  7. Ash2L acts in concert with P53 promoter occupancy to activate RNA Polymerase II by aiding formation of a stable transcription pre-initiation complex required for its activation.

  8. Data suggest that RNA polymerase II inhibitors may be a useful class of agent for targeting dormant leukaemia cells.

  9. This viral pre-initiation complex is composed of five different proteins in addition to Epstein-Barr virus BcRF1 and interacts with cellular RNA polymerase II

  10. Data show that E2F-1 (show E2F1 Proteins) form a complex with RNA polymerase II and protein PURA (show PURA Proteins) for transcriptional activation of the secondary promoter.

POLR2A Protein Profile

Protein Summary

This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

Alternative names and synonyms associated with POLR2A

  • DNA-directed RNA polymerase II largest subunit (NCU02103)
  • DNA-directed RNA polymerase II largest subunit (BBOV_I003360)
  • DNA-directed RNA polymerase II subunit RPB1 (EDI_169920)
  • DNA-directed RNA polymerase II subunit RPB1 (CMU_000800)
  • DNA-directed RNA polymerase II subunit RPB1 (SJAG_01713)
  • DNA-directed RNA polymerase II subunit RPB1 (MGYG_01527)
  • polymerase (RNA) II (DNA directed) polypeptide A, 220kDa (POLR2A)
  • DNA-directed RNA polymerase II largest subunit (TP03_0185)
  • DNA-directed RNA polymerase II largest subunit (EBI_22514)
  • DNA-directed RNA polymerase II largest subunit (CGB_E5020W)
  • polymerase (RNA) II (DNA directed) polypeptide A, 220kDa (polr2a)
  • polymerase (RNA) II (DNA directed) polypeptide A (Polr2a)
  • 19.m02399 protein
  • 220kDa protein
  • hRPB220 protein
  • hsRPB1 protein
  • NCU02103.1 protein
  • POLR2 protein
  • POLR2A protein
  • POLRA protein
  • RPB1 protein
  • RPBh1 protein
  • RpIILS protein
  • RPO2 protein
  • Rpo2-1 protein
  • RPOL2 protein

Protein level used designations for POLR2A

DNA-directed RNA polymerase II subunit RPB1 , polymerase (RNA) II (DNA directed) polypeptide A, 220kDa , 220 kDa DNA-directed RNA polymerase polypeptide A , DNA-directed RNA polymerase II largest subunit , RNA polymerase II polypeptide A , DNA-directed RNA polymerase II A , DNA-directed RNA polymerase II subunit A , DNA-directed RNA polymerase III largest subunit , RNA polymerase II 1 , RNA polymerase II subunit B1 , Polymerase (RNA II (DNA directed), large polypeptide , DNA-directed RNA polymerase II largest subunit, RNA polymerase II 220 kd subunit , RNA-directed RNA polymerase II subunit RPB1 , polymerase (RNA) II (DNA directed) polypeptide A (220kD)

GENE ID SPECIES
3880246 Neurospora crassa OR74A
5477202 Babesia bovis T2Bo
5878979 Entamoeba dispar SAW760
6996694 Cryptosporidium muris RN66
7049878 Schizosaccharomyces japonicus yFS275
10032782 Arthroderma gypseum CBS 118893
454463 Pan troglodytes
479483 Canis lupus familiaris
721865 Macaca mulatta
3500122 Theileria parva strain Muguga
6004135 Enterocytozoon bieneusi H348
10189812 Cryptococcus gattii WM276
100014728 Monodelphis domestica
100144762 Ovis aries
100373197 Saccoglossus kowalevskii
100389642 Callithrix jacchus
100432084 Pongo abelii
100466109 Ailuropoda melanoleuca
100561860 Anolis carolinensis
100607400 Nomascus leucogenys
20020 Mus musculus
363633 Rattus norvegicus
5430 Homo sapiens
282312 Bos taurus
Selected quality suppliers for POLR2A Proteins (POLR2A)
Did you look for something else?