You are viewing an incomplete version of our website. Please click to reload the website as full version.

Enzyme Inhibitors

Modern drug development is about specificity.

Enzyme inhibitors offer a powerful method for blocking specific activity at the metabolic level

  • Enzymes facilitate many of the chemical reactions that are necessary for life: from digestion of nutrients to synthesis of DNA.
  • Enzymes display a very high specificity-of-action, with any given enzyme generally recognizing only one or a handful of potential substrates.
  • Inhibition of a specific enzyme allows a researcher to better understand a metabolic pathway, and opens up avenues for novel drug design

Enzyme inhibitors act by blocking or slowing enzymatic function, significantly reducing the capacity to convert substrates into products

.

Enzyme inhibitors may work in one of several different ways

  • Some inhibitors prevent enzymes from recognizing or binding to substrates, either by masking the substrate or by blocking the active-site on the enzyme. (Competitive inhibition).
  • Alternatively, some enzyme inhibitors may significantly reduce enzymatic activity without affecting substrate recognition or binding. (Non-competitive inhibition)
  • Some enzyme inhibitors are capable of affecting enzymes in a variety of different ways, and can provide a mixture of competitive and non-competitive inhibition (Mixed-inhibition)

Enzyme inhibitors may be reversible or irreversible

  • Reversible enzyme inhibitors form a non-covalent bond with an enzyme. They may temporarily block or slow enzymatic function, but the effects are (by nature) reversible. Reversible enzyme inhibitors are typically easily removed by dilution or dialysis.
  • Irreversible enzyme inhibitors form a covalent bond with an enzyme. They permanently alter the chemical structure of the enzyme thereby irreversibly slowing or blocking enzymatic function.

Enzyme Inhibitors ready for purchase


PathwayInhibitors
ACAT InhibitorsPellitorine
Terpendole C
ACC2 InhibitorsACC2 Inhibitor
Adenylase Cyclase InhibitorsKH7
SQ 22536
Aldo-Keto Reductase (AKR) InhibitorsAKR1C3 Inhibitor I
AKR1C3 Inhibitor II
AKR1C3 Inhibitor III
Angiogenesis Inhibitors2-Methoxyestradiol
BIBF1120
Borrelidin
Castanospermine
Fumagillin
Isoxanthohumol
Thiabendazole
Tranilast
Angiotensin Receptor AntagonistsValsartan
Arginase InhibitorsBEC
ATPase Inhibitors(-)-Blebbistatin
Bafilomycin A1
Bufalin
Autophagy Inhibitors3-Methyladenine
ATM Kinase Inhibitor, KU-55933
Bafilomycin A1
Chloroquine Diphosphate
Go 6976
Spautin-1
Bcl-2 InhibitorsABT-263
ABT-737
AT-101
BCl-2 Inhibitor GX15-070
BCl-2 Inhibitor, ABT-199
BMP InhibitorsEZSolutionTM LDN193189
LDN193189
Bone Resorption InhibitorsAlendronate sodium
Pamidronate disodium
Bromodomain Inhibitors(-)-JQ1
Bromodomain Inhibitor, (+)-JQ1
I-BET151
PFI-1
Calpain InhibitorsCalpain Inhibitor I, ALLN
Calpain Inhibitor II, ALLM
Calpain Inhibitor Z-LLY-FMK
MDL 28170
PD 150,606
Caspase & Granzyme B InhibitorsBiotin-DEVD-FMK
Biotin-IETD-FMK
Biotin-VAD-FMK
Caspase Inhibitor Boc-D-FMK
Caspase-1 Inhibitor Z-YVAD-FMK
Caspase-10 Inhibitor AEVD-FMK
Caspase-12 Inhibitor
Caspase-13 Inhibitor LEED-FMK
Caspase-2 Inhibitor Z-VDVAD-FMK
Caspase-3 Inhibitor Q-DEVD-OPh
Caspase-3 Inhibitor Z-DEVD-FMK
Caspase-4 Inhibitor Z-LEVD-FMK
Caspase-5 Inhibitor Z-WEHD-FMK
Caspase-6 Inhibitor Z-VEID-FMK
Caspase-8 Inhibitor Z-IETD-FMK
Caspase-8 Inhibitor, Q-IETD-OPh
Caspase-9 Inhibitor Z-LEHD-FMK
Caspase-9 Inhibitor, Q-LEHD-OPh
EMAP-II Inhibitor Z-ASTD-FMK
EZSolutionTM Q-VD-OPh, Negative Control
FMK Negative Control
Granzyme B Inhibitor Ac-IEPD-CHO
Q-VD-OPh
Z-ATAD-FMK
Caspase-3 Inhibitor Z-DEVD-FMK
Z-FA-FMK
Caspase-8 Inhibitor Z-IETD-FMK
Caspase-9 Inhibitor Z-LEHD-FMK
Caspase-4 Inhibitor Z-LEVD-FMK
Caspase-Family Inhibitor Z-VAD-FMK