anti-Immunoglobulin M (IgM) secondary antibodies

Immunoglobulin M (IgM) is constructed of five or six units (i.e. mostly as pentamers but also hexamers occur) which are each comprised of two heavy-chains (mu-chains) and two light chains, bound together by disulfide bonds and a so-called J-chain. A J-chain is usually, but not always, found in pentameric IgM but not in the hexameric form. It is not yet clear if pentamers without the J-chain fullfill different functions. Each monomer has two antigen binding sites, hence a pentameric IgM has 10 binding sites. IgM is by far largest antibody in the human circulatory system. In its pentamer form IgM has a molecular mass of approximately 900 kDa.

IgM is present on B cells and its main function apparently is the control of B-cell activation. Interestingly, it is also the primary antibody against A and B antigens on red blood cells and responsible for the blood-clotting reaction during blood-transfusion from wrong donors.

IgM is primarily found in serum and due to its size, it cannot diffuse well, and is found in the interstitium only in very low quantities.

The table below contains a selection of anti-IgM secondary antibodies:

anti-Immunoglobulin M
Reactivity	Host	Unconj.	AP	Biotin	FITC	HRP	Texas Red	Rhodamine
Human	Goat	ABIN102624	ABIN102625	ABIN102626	ABIN102627	ABIN102628	ABIN102629	ABIN102630
Human	Goat	ABIN102640	ABIN102641	ABIN102642	ABIN102644	ABIN102645	ABIN102646	ABIN336547
Mouse	Goat	ABIN102674	ABIN102675	ABIN102676	ABIN102677	ABIN102678	ABIN102679	ABIN102680
Mouse	Rabbit	ABIN102682	ABIN102683	ABIN102684	-	ABIN102685	ABIN102686	ABIN102687
Rat	Rabbit	ABIN102711	ABIN102712	ABIN102713	ABIN102714	ABIN102715	ABIN102716	ABIN102717
Chicken	Mouse	ABIN135557	-	ABIN135558	ABIN135559	-	-	-
Chicken	Mouse	ABIN135557	-	ABIN135558	ABIN135559	-	-	-