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Human Factor VII ELISA Kit for Sandwich ELISA - ABIN417285
Teligui, Dalmayrac, Corbeau, Bouquet, Godon, Denommé, Binuani, Verron, Boer, Baufreton: Ex vivo simulation of cardiopulmonary bypass with human blood for hemocompatibility testing. in Perfusion 2016
Mouse (Murine) Factor VII ELISA Kit for Sandwich ELISA - ABIN425161
Wang, Braun, Zhang, Norström, Thorlacius: Monocytes regulate systemic coagulation and inflammation in abdominal sepsis. in American journal of physiology. Heart and circulatory physiology 2015
Hepsin (show HPN ELISA Kits) plays a physiologically important role in factor VII (show TH ELISA Kits) activation and hemostasis in zebrafish.
study reports the full-length cDNA sequences of rhesus monkey FVII; deduced protein sequence of FVII indicates the functional domains; comparison of three-dimensional protein structure with human shows high conservation between them
FVIIa-antithrombin (show SERPINC1 ELISA Kits) but not FVIIa is a ligand for LRP1 (show LRP1 ELISA Kits), and LRP1 (show LRP1 ELISA Kits) contributes to the clearance of FVIIa-antithrombin (show SERPINC1 ELISA Kits) in vivo
FVIIa binding to EPCR (show PROCR ELISA Kits) leads to a barrier protective effect in vivo
FVIIa binding to EPCR (show PROCR ELISA Kits) on the endothelium facilitates the transport of FVIIa from circulation to extravascular tissues where TF resides
Murine FVIIa binds poorly to murine EPCR (show PROCR ELISA Kits).
Conclude that the fVII-targeted verteporfin photodynamic therapy that we report here is a novel and effective therapeutic with improved selectivity for the treatment of breast cancer.
The participation of Egr-1 (show EGR1 ELISA Kits) in FVIIa-mediated regulation of keratinocyte function was confirmed by use of Egr-1 (show EGR1 ELISA Kits)-deficient mice, wherein a significant delay in skin wound healing after injury was observed, relative to WT mice.
Recombinant FVIIa readily associates with the vascular endothelium and subsequently enters into extravascular spaces where it is likely to bind to tissue factor (show F3 ELISA Kits) and is retained for extended time periods.
Gene targeting of tissue factor (show F3 ELISA Kits), factor X, and factor VII (show TH ELISA Kits) in mice: their involvement in embryonic development
true circadian rhythms for FVII were found
Data suggest that long-term expression of murine activated factor VII (show TH ELISA Kits) is safe, but elevated levels cause premature mortality.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
A coagulation initiating pathway is revealed in which the TF-FVIIa-nascent FXa (show F10 ELISA Kits) complex activates FVIII (show F8 ELISA Kits) apart from thrombin (show F2 ELISA Kits) feedback.
Data suggest activation of PAR2 (show F2RL1 ELISA Kits) via FVIIA/TF signaling activates PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) signaling, inactivates GSK3b (show GSK3b ELISA Kits) signaling, leads to accumulation of beta-catenin (show CTNNB1 ELISA Kits), and promotes tumor cell migration/invasion. (PAR2 (show F2RL1 ELISA Kits) = protease-activated receptor 2 (show F2RL1 ELISA Kits); FVIIA = coagulation factor VIIa; TF = tissue factor/thromboplastin (show F3 ELISA Kits); PI3K (show PIK3CA ELISA Kits) = phosphatidylinositol 3-kinase; AKT (show AKT1 ELISA Kits) = proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (show AKT1 ELISA Kits); GSK3b (show GSK3b ELISA Kits) = glycogen synthase kinase 3 beta (show GSK3b ELISA Kits))
heterozygotes for FVII deficiency show rare bleeding manifestations which are also present in the unaffected family members with normal FVII levels. This indicates that Factor VII (show TH ELISA Kits) activity levels played no role in the occurrence of the bleeding symptoms. Furthermore, FVII levels of around 0.40 IU/dl are capable of assuring a normal hemostasis.
Family-based association study revealed that the G allele of Protein Z (show PROZ ELISA Kits) rs2273971, and haplotypes GA, CG, and CGA (show CGA ELISA Kits) of Protein Z (show PROZ ELISA Kits) and factor VII (show TH ELISA Kits) had a significant effect on cerebral hemorrhage susceptibility.
Circulating FVII, FVIIa and TFPI (show TFPI ELISA Kits) were significantly elevated in women with severe preeclampsia in the absence of comparable changes in plasma TF levels.
Our study findings suggest a link between FVII and AR in prostate cancer pathogenesis.
Large deletions play a minor but essential role in the mutational spectrum of the F7 and F10 (show F10 ELISA Kits) genes. Copy number analyses (e. g. MLPA) should be considered if sequencing cannot clarify the underlying reason of an observed coagulopathy. Of note, in cases of combined FVII/FX deficiency, a deletion of the two contiguous genes might be part of a larger chromosomal rearrangement.
Structure-Function Relationship of the Interaction between Tissue Factor (show F3 ELISA Kits) and Factor VIIa.
This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
coagulation factor VII
, clotting factor
, serum prothrombin conversion accelerator
, FVII coagulation protein
, eptacog alfa