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results highlight the clinical significance of PARN (show PARN Proteins) and NOC on the survival in SCC (show CYP11A1 Proteins) diagnosed patients.
Three tag SNPs (rs938836, rs17050680, rs3805213) in the CCRN4L are significant correlation with genotype and allele frequency in lung cancer.
Genetic variation in the NOC gene is associated with body mass index in Chinese subjects.
Ccr4d functions as an anti-proliferating protein through the induction of cell cycle arrest via a p21 (show CDKN1A Proteins)-dependent and p53 (show TP53 Proteins)-independent pathway and suggest that Ccr4d might have an important role in carcinogenesis.
A human lung cancer cell line SBC-5 that efficiently metastasized to bone when intravenously injected into SCID (show PRKDC Proteins) mice was found to express CCR4 (show CCR4 Proteins).
The transcription of human nocturnin gene displayed circadian oscillations in Huh7 cells (a human hepatoma cell line) and was regulated by CLOCK/BMAL1 heterodimer via the E-box of nocturnin promoter.
Data suggest that Nocturnin (NOC) exerts strong effects on physiology through direct and indirect control of target mRNAs.
precise expression of nocturnin is critical to proper development of early mouse embryos
Nocturnin plays a role in linking nutrient sensing by the circadian clock to lipid mobilization in the adipocytes
data suggest that Nocturnin has a novel stabilizing activity that plays an important role in the circadian response to inflammatory signals
Loss of nocturnin enhances bone formation; the circadian rhythm of Noc is likely to be an essential element of marrow stromal cell fate.
Data suggest that nocturnin plays an important role in the trafficking of dietary lipid in the intestinal enterocytes by optimizing efficient absorption of lipids.
Noc interacts with Igf1 in a strain- and tissue-specific manner and reduces Igf1 expression by targeting the longer form of the Igf1 3'UTR.
Noc plays a unique role in the regulation of mesenchymal stem-cell lineage allocation by modulating PPAR-gamma (show PPARG Proteins) activity through nuclear translocation.
Nocturnin, is markedly upregulated with Pparg (show PPARG Proteins) activation in adipocytes and bone marrow stromal cells.
nocturnin exhibits circadian rhythmicity of mRNA abundance with peak levels at the time of light offset in the retina, spleen, heart, kidney and liver.
Data suggest that nocturnin deadenylates clock-related transcripts in a novel mechanism for posttranscriptional regulation in the circadian clock or its outputs.
nocturnin is a circadian clock-regulated gene identified by differential display
The Drosophila melanogaster homolog of the vertebrate circadian gene nocturnin is expressed in a subset of dorsal neurons and mediates the circadian light response.
The protein encoded by this gene is highly similar to Nocturnin, a gene identified as a circadian clock regulated gene in Xenopus laevis. This protein and Nocturnin protein share similarity with the C-terminal domain of a yeast transcription factor, carbon catabolite repression 4 (CCR4). The mRNA abundance of a similar gene in mouse has been shown to exhibit circadian rhythmicity, which suggests a role for this protein in clock function or as a circadian clock effector.
CCR4 protein homolog
, CCR4-like (carbon catabolite repression 4, S.cerevisiae)
, CCR4 carbon catabolite repression 4-like
, carbon catabolite repression 4 homolog
, CCR4 carbon catabolite repression 4-like B
, carbon catabolite epression 4 homolog
, CCR4 carbon catabolite repression 4-like, nocturnin
, rhythmic message 1
, CC-chemokine receptor 4
, C-C chemokine receptor type 4
, chemokine (C-C motif) receptor 4