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anti-Human DDX1 Antibodies:
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Human Monoclonal DDX1 Primary Antibody for IF, WB - ABIN968420
Amler, Schürmann, Schwab: The DDX1 gene maps within 400 kbp 5' to MYCN and is frequently coamplified in human neuroblastoma. in Genes, chromosomes & cancer 1996
Show all 4 Pubmed References
Human Monoclonal DDX1 Primary Antibody for IF, WB - ABIN968421
Godbout, Packer, Bie: Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines. in The Journal of biological chemistry 1998
Show all 4 Pubmed References
Human Polyclonal DDX1 Primary Antibody for ICC, IF - ABIN152383
Zhang, Kim, Bao, Facchinetti, Jung, Ghaffari, Qin, Cheng, Liu: DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells. in Immunity 2011
These data suggest a role for Drosophila Ddx1 in stress-induced regulation of splicing.
DEAD-box protein (show INTS6 Antibodies) Bel (show LHX2 Antibodies) has evolutionarily conserved roles in fertility and development.
data have demonstrated that Venezuelan equine encephalitis virus (VEEV)-nsP3 associates with DDX1 and DDX3 in infected cells to facilitate viral multiplication; determined that VEEV-nsP3 interacts with a pre-formed translational complex, comprising of DX3:eIF4A:eIF4G:PABP to potentially aid in translation of viral proteins.
the two structural homologs FAM98A and FAM98B included in a novel complex with DDX1 and C14orf166 (show C14orf166 Antibodies) are required for PRMT1 (show PRMT1 Antibodies) expression in colorectal cancer cell lines
DDX1 binds HIV-1 rev response element to promote virus assembly.
DDX1, a RNA helicase (show DDX46 Antibodies) also implicated in DSB repair, interacts with RIF1 (show INSL6 Antibodies). Recruitment of DDX1 to DSBs is dependent on RIF1 (show INSL6 Antibodies). DDX1 is also required for chromatin loading of BLM to ionizing radiation-induced DSBs. DDX1 and RIF1 (show INSL6 Antibodies) have different nucleic acid requirements for accumulation at DSBs, with RNA-DNA hybrids required for DDX1 accrual at DSBs, and single-strand RNA required for accumulation of RIF1 (show INSL6 Antibodies) at these sites.
Data provide evidence for a role for DDX1 in resolving RNA-DNA structures that accumulate at DNA double-strand breaks located at sites of active transcription thereby facilitating repair by homologous recombination.
crystal structure of the SPRY domain of human DDX1 (hDSPRY) is reported at 2.0 A resolution
HIV-1 wild type Tat (show TAT Antibodies) co-immunoprecipitated with DDX1.
Data indicate a tight binding of DEAD-box protein DDX1 to adenosine diphosphate (ADP), one of the strongest affinities observed for DEAD-box helicases.
hCLE/C14orf166 associates with DDX1, HSPC117, and FAM98B in a novel transcription-dependent shuttling RNA-transporting complex.
archease (also called ZBTB8OS), a protein of unknown function, is required for full activity of the human tRNA ligase complex and, in cooperation with DDX1, facilitates the formation of an RTCB-guanylate intermediate central to mammalian RNA ligation
we show that the transcript levels of an RNA helicase, Ddx1, regulates strain differences in the amount of nitric oxide produced by macrophage after stimulation with interferon gamma (show IFNG Antibodies) and tumor necrosis factor (show TNF Antibodies).
Coronavirus N phosphorylation by GSK-3 (show GSK3b Antibodies) allows recruitment of the RNA helicase DDX1, which facilitates template readthrough and enables longer viral positive-sense single-stranded genomic RNA synthesis.
DDX1 promotes the expression of a subset of microRNAs. Knockdown of DDX1 promotes ovarian tumor invasion and metastasis.
DDX1-DDX21 (show DDX21 Antibodies)-DHX36 (show DHX36 Antibodies) complex represents a dsRNA sensor that uses the TRIF (show RNF138 Antibodies) pathway to activate type I IFN responses in the cytosol of myeloid dendritic cells
DDX1 mRNA was produced in both seminoma and nonseminoma types of human testicular germ cell tumor samples
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin.
, DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
, ATP-dependent RNA helicase DDX1
, DEAD box polypeptide 1
, DEAD box protein 1
, DEAD box protein retinoblastoma
, DEAD box-1
, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
, DEAD box protein DDX1