Browse our Pantothenate Kinase 2 Proteins (PANK2)

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Pantothenate Kinase 2 Proteins (PANK2)
On www.antibodies-online.com are 3 Pantothenate Kinase 2 (PANK2) Proteins from 3 different suppliers available. Additionally we are shipping Pantothenate Kinase 2 Antibodies (83) and many more products for this protein. A total of 94 Pantothenate Kinase 2 products are currently listed.
Synonyms:
4933409I19Rik, AI642621, ATPANK2, C20orf48, F10M6.180, F10M6_180, HARP, HSS, NBIA1, PANK2, pantothenate kinase 2, PKAN
list all proteins Gene Name GeneID UniProt
PANK2 80025 Q9BZ23
Mouse PANK2 PANK2 74450  
Rat PANK2 PANK2 296167  

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Pantothenate Kinase 2 Proteins (PANK2) by Origin

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Human Pantothenate Kinase 2 (PANK2) interaction partners

  1. These findings provide direct evidence that PANK2 malfunctioning is responsible for abnormal phenotypes in human neuronal cells of pantothenate kinase (show FBL Proteins)-associated neurodegeneration patients.

  2. A deleterious homozygous four-nucleotide deletion causing frameshift deletion in PANK2 gene (c.1426_1429delATGA, p.M476 fs) was identified in an 8 years old girl with dystonia, bone fracture, muscle rigidity, abnormal movement, lack of coordination and chorea.

  3. Results show that overexpression of PANK2 results in substantial elevated level of Co-A in skeletal muscle in transgenic mice which displays reduced skeletal muscle mass and significantly impaired exercise tolerance and grip strength.

  4. Homozygous PANK2 mutations in 22 PKAN patients from 13 Turkish families.

  5. We aim to present a case of a healthy infant born after intracytoplasmic sperm injection-in vitro fertilization (ICSI-IVF (show SCN5A Proteins)) with a preimplantation genetic diagnosis (PGD (show PGD Proteins)) for pantothenate kinase (show FBL Proteins)-associated neurodegeneration (PKAN) due to PANK2 mutation

  6. Tissue or cellular hypoxic/ischemic injury within the globus pallidus may underlie the pathogenesis of pantothenate kinase (show FBL Proteins)-associated neurodegeneration due to PANK2 mutations and apoE (show APOE Proteins) aggregates.

  7. Mutations in PANK2 and CoASY lead, respectively, to PKAN and CoPAN forms of Neurodegeneration with brain iron accumulation . Mutations in PLA2G6 lead to PLAN. Mutations in C19orf12 lead to MPAN

  8. Data suggests that the c.680 A>G mutation in the PANK2 gene alone is not sufficient to determine acanthocytic shape transformation in erythrocytes but some additional factor(s)/condition(s) are necessary for acanthocytosis to occur.

  9. Novel PANK2 gene mutations and clinical features in patients with pantothenate kinase (show FBL Proteins)-associated neurodegeneration.

  10. study presents 2 siblings who were homozygous for a novel c.695A>G (p.Asp232Gly) missense mutation in exon 2 of PANK2 gene; index patient presented with a 5-year history of slowly progressive gait disturbance, dysarthria, mild axial rigidity and bradykinesia

Mouse (Murine) Pantothenate Kinase 2 (PANK2) interaction partners

  1. Pank2(-/-) mice fed with a ketogenic diet developed a pantothenate kinase (show FBL Proteins)-associated neurodegeneration-like syndrome

  2. Data demonstrate that Pank2 localizes to mitochondria. Pank2-defective neurons have an altered mitochondrial membrane potential, a defect further corroborated by swollen mitochondria at the ultra-structural level and by defective respiration.

  3. The data indicate that PanK1 and PanK2 can compensate for each other to supply tissue CoA.

  4. expression of PanK2 was higher in human brain compared to mouse brain

Pantothenate Kinase 2 (PANK2) Protein Profile

Protein Summary

This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.

Alternative names and synonyms associated with Pantothenate Kinase 2 (PANK2)

  • pantothenate kinase 2 (PANK2)
  • pantothenate kinase 2 (Tsp_01576)
  • pantothenate kinase 2 (Pank2)
  • ribonuclease, RNase A family, 11 (non-active) (RNASE11)
  • 4933409I19Rik protein
  • AI642621 protein
  • ATPANK2 protein
  • C20orf48 protein
  • F10M6.180 protein
  • F10M6_180 protein
  • HARP protein
  • HSS protein
  • NBIA1 protein
  • PANK2 protein
  • pantothenate kinase 2 protein
  • PKAN protein

Protein level used designations for Pantothenate Kinase 2 Proteins (PANK2)

pantothenate kinase 2 (Hallervorden-Spatz syndrome) , pantothenate kinase 2 , pantothenate kinase 2, mitochondrial-like , Hallervorden-Spatz syndrome , pantothenate kinase 2, mitochondrial , pantothenic acid kinase 2

GENE ID SPECIES
458070 Pan troglodytes
829351 Arabidopsis thaliana
10911642 Trichinella spiralis
100217410 Ovis aries
100432599 Pongo abelii
100539295 Meleagris gallopavo
80025 Homo sapiens
74450 Mus musculus
477168 Canis lupus familiaris
296167 Rattus norvegicus
783426 Bos taurus
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