PANK2 Products
(Pantothenate Kinase 2 (PANK2))
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This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008].
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Featured PANK2 Categories
PANK2 Antibodies
High quality antibodies with extensive validation data.
PANK2 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended PANK2 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Dog, Human, Monkey, Rat
Application
WB, IHC, IF, IHC (p), FACS
Validations
- (8)
Cat. No.
ABIN1500026
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (3)
Cat. No.
ABIN7162603
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (3)
Cat. No.
ABIN566414
Quantity
100 μg
Datasheet
Datasheet
Recommended PANK2 ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6206931
Quantity
96 tests
Datasheet
Datasheet
Recommended PANK2 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN3013381
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Insect Cells
Validations
- (1)
Cat. No.
ABIN3085454
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7421605
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our PANK2 products
: "Mitochondrial iron and energetic dysfunction distinguish fibroblasts and induced neurons from pantothenate kinase-associated neurodegeneration patients." in: Neurobiology of disease, (2015) (PubMed).: "Glycyrrhizin suppresses lung adenocarcinoma cell growth through inhibition of thromboxane synthase." in: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, Vol. 33, Issue 2, pp. 375-88, (2014) (PubMed).
: "DNA damage-specific deubiquitination regulates Rad18 functions to suppress mutagenesis." in: The Journal of cell biology, Vol. 206, Issue 2, pp. 183-97, (2014) (PubMed).
: "Regulation of murine hepatic hydroxysteroid sulfotransferase expression in hyposulfatemic mice and in a cell model of 3'-phosphoadenosine-5'-phosphosulfate deficiency." in: Drug metabolism and disposition: the biological fate of chemicals, Vol. 41, Issue 8, pp. 1505-13, (2013) (PubMed).
: "Pantothenate kinase-associated neurodegeneration: altered mitochondria membrane potential and defective respiration in Pank2 knock-out mouse model." in: Human molecular genetics, Vol. 21, Issue 24, pp. 5294-305, (2012) (PubMed).
: "An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria." in: Human molecular genetics, Vol. 12, Issue 3, pp. 321-7, (2003) (PubMed).
: "Compound heterozygous PANK2 mutations confirm HARP and Hallervorden-Spatz syndromes are allelic." in: Neurology, Vol. 61, Issue 10, pp. 1423-6, (2003) (PubMed).
: "HARP syndrome is allelic with pantothenate kinase-associated neurodegeneration." in: Neurology, Vol. 58, Issue 11, pp. 1673-4, (2002) (PubMed).
Synonyms and alternative names related to PANK2
pantothenate kinase 2 (PANK2), pantothenate kinase 2 (Tsp_01576), pantothenate kinase 2, mitochondrial (LOC100539295), pantothenate kinase 2 (Pank2), ribonuclease A family member 11 (inactive) (RNASE11), 4933409I19Rik, AI642621, ATPANK2, C20orf48, F10M6.180, F10M6_180, HARP, HSS, NBIA1, PANK2, pantothenate kinase 2, PKANProtein level used designations for PANK2
- pantothenate kinase 2 (Hallervorden-Spatz syndrome)
- pantothenate kinase 2
- pantothenate kinase 2, mitochondrial-like
- Hallervorden-Spatz syndrome
- pantothenate kinase 2, mitochondrial
- pantothenic acid kinase 2
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