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Apoptosis-associated tyrosine kinase is a Cdk5 (show CDK5 Proteins) activator p35 binding protein.
LMTK1 negatively controls dendritic formation by regulating Rab11A (show RAB11A Proteins)-positive endosomal trafficking.
Overexpression of the unphosphorylated mutant LMTK1-S34A dramatically promotes axonal outgrowth in cultured neurons.
results suggest a possibility that AATYK1A plays a role in early to recycling endosomes and its function is regulated by phosphorylation with Cdk5 (show CDK5 Proteins) or Src (show SRC Proteins)-family kinases
Expression of AATYK mRNA and protein increased during postnatal brain development. In immature granule cells, overexpression of AATYK promoted neurite outgrowth; a tyrosine kinase (show TYRO3 Proteins)-defective mutant significantly inhibited it.
phosphorylation states of AATYK are closely related to the high potassium-induced survival and low potassium-induced apoptosis of cerebellar granule cells
AATYK1 indirectly inhibits the SPAK (show STK39 Proteins)/WNK4 (show WNK4 Proteins) activation of the Na-K-2Cl cotransporter (show SLC12A1 Proteins) by scaffolding an inhibitory phosphatase in proximity to a stimulatory kinase.
The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
, brain apoptosis-associated tyrosine kinase
, lemur tyrosine kinase 1
, p35-binding protein
, serine/threonine-protein kinase LMTK1
, apoptosis-associated tyrosine kinase 1B