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This study provided the first evidence that the Arp2/3 complex, a key actin nucleator, is involved in distinct stages of spine formation and is required for synapse unsilencing.
In the absence of ArpC3, enterocytes had defects in the organization of the endolysosomal system: transcytosis of IgG was disrupted, lipid absorption was perturbed, and neonatal mice died within days of birth.
GMF debranches filaments by a mechanism related to cofilin-mediated severing, but in which GMF has evolved to target molecular junctions between actin-related proteins in the Arp2/3 complex and actin subunits in the daughter filament of the branch.
Together with the observation that Gadkin-mediated inhibition of cell spreading requires its binding to ARP2 (show AICDA Proteins)/3, these data indicate that Gadkin is a negative regulator of ARP2 (show AICDA Proteins)/3 function present on intracellular membranes
results demonstrate a critical role for the Arp2 (show AICDA Proteins)/3 complex in the assembly of lamellipodia-based leading edges and directional cell motility
that targeting of Arpc3 by miR-29a/b fine tunes structural plasticity by regulating actin network branching in mature and developing spines
These data indicate the importance of Arpc3 in the Arp2 (show AICDA Proteins)/3 complex for trophoblast outgrowth and suggest that Arpc3 may be indispensable for implantation.
Cancer cell motility mediated by the actin-related protein 2 (show ACTR2 Proteins)/3 complex (Arp2 (show ACTR2 Proteins)/3) is required for vessel co-option in liver metastases in vivo.
genetic association study in population in Canada: Data suggest that an SNP in the promoter region of ARPC3 (CpG-SNP rs3759384 C>T) is associated with metabolic syndrome complicated by severe abdominal obesity and hypertriglyceridemia in the population studied.
Endogenous Nogo-B (show RTN4 Proteins), which may exert its effects through ARPC 2 (show ARPC2 Proteins)/3 and MYL-9 (show MYL9 Proteins), is necessary for the migration and contraction of airway smooth muscle cells.
The actin-related protein 3 (show ACTR3 Proteins) structures were more visible with anti-p34Arc monoclonal antibody.
The GMF-Arp2 interface reveals how the ADF-H actin-binding domain in GMF is exploited to specifically recognize Arp2/3 complex and not actin.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p21 subunit, has yet to be determined.
actin related protein 2/3 complex, subunit 3
, actin-related protein 2/3 complex subunit 3
, actin related protein 2/3 complex, subunit 3, 21kDa
, Arp2/3 complex subunit p21-Arc
, arp2/3 complex 21 kDa subunit
, ARP2/3 protein complex subunit p21
, actin related protein 2/3 complex subunit 3