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|Antigen||Betacellulin (BTC) Antibodies|
|Conjugate||This Betacellulin antibody is conjugated to Alexa Fluor 488 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-Betacellulin AntibodyTarget Details Betacellulin Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human Betacellulin|
Target Details BetacellulinProduct Details anti-Betacellulin Antibody Application Details Handling Images back to top
|Alternative Name||beta Cellulin (BTC Antibody Abstract)|
Betacellulin (BTC), a member of the epidermal growth factor (EGF) family, was originally identified as a growth-promoting factor in the conditioned medium of a mouse pancreatic-cell carcinoma (insulinoma) cell line and has since been identified in humans. BTC is synthesized as a large transmembrane precursor molecule that can be cleaved proteolytically to release the soluble form of BTC or function as membrane-anchored growth factors in juxtacrine signaling. BTC, in addition to stimulating homodimers of ErbB-1 and ErbB-4, is capable of binding and activating all possible combinations of heterodimeric ErbB receptors including the oncogenic ErbB-2/ErbB-3 complex. BTC is also expressed in some human malignancies and may have an important role in tumor growth progression.
Subcellular location: Extracellular
Synonyms: Beta cellulin, Beta cellulin precursor, BTC, BTC_HUMAN, OTTHUMP00000160600, OTTHUMP00000219057, Probetacellulin.
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-Betacellulin Antibody Target Details Betacellulin Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-Betacellulin Antibody Target Details Betacellulin Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|