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|Antigen||Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Antibodies|
|Epitope||AA 304-320, AA 297-327 Alternatives|
|Conjugate||This DDR2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|5 references available|
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Product Details anti-DDR2 AntibodyTarget Details DDR2 Application Details Handling References for anti-DDR2 antibody (ABIN359956) Images
|Specificity||This antibody recognizes DDR2 (TYRO10).|
|Purification||Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS|
|Immunogen||KLH conjugated synthetic peptide between 297~327 amino acids from aa 304~320 of Human TYRO10.|
Target Details DDR2Product Details anti-DDR2 Antibody Application Details Handling References for anti-DDR2 antibody (ABIN359956) Images back to top
|Alternative Name||CD167b / DDR2 (DDR2 Antibody Abstract)|
|Background||Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane and cytoplasmic regions. There are several subclasses of RTKs and TYRO10 belongs to a novel subclass. The deduced amino acid sequence of TYRO10 has a unique extracellular region encompassing a factor VIII-like domain, not previously described for RTKs.Synonyms: CD167 antigen-like family member B, Discoidin domain-containing receptor 2, Discoidin domain-containing receptor tyrosine kinase 2, NTRKR3, Neurotrophic tyrosine kinase receptor-related 3, Receptor protein-tyrosine kinase TKT, TKT, TYRO10, Tyrosine-protein kinase TYRO10|
|Gene ID||4921, 9606|
Application DetailsProduct Details anti-DDR2 Antibody Target Details DDR2 Handling References for anti-DDR2 antibody (ABIN359956) Images back to top
ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-DDR2 Antibody Target Details DDR2 Application Details References for anti-DDR2 antibody (ABIN359956) Images back to top
|Buffer||PBS, 0.09 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-DDR2 antibody (ABIN359956)Product Details anti-DDR2 Antibody Target Details DDR2 Application Details Handling Images back to top
Vogel, Gish, Alves, Pawson: "The discoidin domain receptor tyrosine kinases are activated by collagen." in: Molecular cell, Vol. 1, Issue 1, pp. 13-23, 1998
Edelhoff, Sweetser, Disteche: "Mapping of the NEP receptor tyrosine kinase gene to human chromosome 6p21.3 and mouse chromosome 17C." in: Genomics, Vol. 25, Issue 1, pp. 309-11, 1995
Karn, Holtrich, Bräuninger, Böhme, Wolf, Rübsamen-Waigmann, Strebhardt: "Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain." in: Oncogene, Vol. 8, Issue 12, pp. 3433-40, 1993
Lapsys, Layfield, Baker, Callen, Sutherland, Abedinia, Nixon, Mattick: "Chromosomal location of the human transketolase gene." in: Cytogenetics and cell genetics, Vol. 61, Issue 4, pp. 274-5, 1993
Abedinia, Layfield, Jones, Nixon, Mattick: "Nucleotide and predicted amino acid sequence of a cDNA clone encoding part of human transketolase." in: Biochemical and biophysical research communications, Vol. 183, Issue 3, pp. 1159-66, 1992
ImagesProduct Details anti-DDR2 Antibody Target Details DDR2 Application Details Handling References for anti-DDR2 antibody (ABIN359956) back to top