The protein encoded by this gene is a member of the fibroblast growth factor (FGF)family. FGF family members possess broad mitogenic and cell survival activities and areinvolved in a variety of biological processes including embryonic development, cellgrowth, morphogenesis, tissue repair, tumor growth and invasion. The product of thisgene inhibits renal tubular phosphate transport. This gene was identified by itsmutations associated with autosomal dominant hypophosphatemic rickets (ADHR), aninherited phosphate wasting disorder. Abnormally high level expression of this gene wasfound in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similardisease caused by abnormal phosphate metabolism. Mutations in this gene have alsobeen shown to cause familial tumoral calcinosis with hyperphosphatemia. Alternate Names: anti-FGF23 antibody, anti-fibroblast growth factor 23antibody, anti-ADHR antibody,anti-HPDR2 antibody, anti-HYPF antibody, anti-PHPTCantibody, anti-tumor-derivedhypophosphatemia inducing factor antibody. Gene Symbol: FGF23
Tris-saline [ pH 7.3] with 0.5 % BSA, Sodium Azide
Precaution of Use
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.