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anti-Chimpanzee FGFR1 antibody for Western Blotting

Recommended FGFR1 Antibody (supplied by: Log in to see )

Antigen
Fibroblast Growth Factor Receptor 1 (FGFR1) Antibodies
  • ach
  • AW208770
  • bFGF-R-1
  • BFGFR
  • bfgfr
  • cb231
  • CD331
  • cd331
  • cd333
  • cek
  • CEK
  • cek2
  • CG7223
  • CT22273
  • CT39172
  • DFGF-R1
  • DFGF-R2
  • DFR-1
  • Dfr-1
  • Dfr1
  • DFR1
  • DFR1/DFGF-R2
  • Dmel\\CG7223
  • DmHD-38
  • DPR3
  • Dtk1
  • dtk1
  • DTRK(FR1)
  • Eask
  • EMS2
  • FGF-R2
  • fgfbr
  • FGFBR
  • fgfr
  • FGFR
  • FGFR-1
  • Fgfr-1
  • fgfr-1
  • fgfr-3
  • fgfr1
  • FGFR2
  • FGFRI
  • flg
  • FLG
  • FLG-1
  • FLT-2
  • Flt-2
  • flt-2
  • flt2
  • FLT2
  • Fr1
  • FR1
  • HBGFR
  • hbgfr
  • HD-38
  • HH2
  • hsfgfr3ex
  • Hspy
  • Htl
  • HTL/FGFR1
  • i79
  • i100
  • i150
  • j372
  • jtk4
  • kal2
  • KAL2
  • N-SAM
  • n-sam
  • OGD
  • ogd
  • sb:cb231
  • Tk1
  • X1FGFR
  • x1fgfr
  • XFGFR-1
  • xfgfr1
  • XFGFRA2
Epitope
C-Term
61
55
52
43
42
34
32
29
27
27
24
22
18
18
16
15
11
10
10
9
7
6
6
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Dog (Canine), Chimpanzee, Human
574
217
176
15
10
9
7
4
4
4
3
2
1
1
Host
Goat
403
159
31
Clonality
Polyclonal
Conjugate
This FGFR1 antibody is un-conjugated
31
27
27
24
20
20
8
8
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
4
3
3
Application
Western Blotting (WB)
492
247
191
124
100
95
44
26
25
20
19
10
2
1
1
1
Supplier
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Catalog No. ABIN374521
$ 379.50
Plus shipping costs $45.00

Top referenced anti-FGFR1 antibody for Western Blotting

Similar anti-FGFR1 Antibodies

Application / Reactivity Human Dog (Canine) Chimpanzee
Western Blotting (WB) 491 Antibodies 8 Antibodies 1 Antibodies
Proximity Ligation Assay (PLA) 2 Antibodies
Immunoprecipitation (IP) 126 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 103 Antibodies 2 Antibodies
Immunohistochemistry (IHC) 197 Antibodies 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 24 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 44 Antibodies
Immunofluorescence (IF) 28 Antibodies
Immunocytochemistry (ICC) 21 Antibodies
Flow Cytometry (FACS) 96 Antibodies
Enzyme Immunoassay (EIA) 10 Antibodies 2 Antibodies

General

Antigen Fibroblast Growth Factor Receptor 1 (FGFR1) Antibodies
Epitope C-Term
(61), (55), (52), (43), (42), (34), (32), (29), (27), (27), (24), (22), (18), (18), (16), (15), (11), (10), (10), (9), (7), (6), (6), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Dog (Canine), Chimpanzee, Human
(574), (217), (176), (15), (10), (9), (7), (4), (4), (4), (3), (2), (1), (1)
Host Goat
(403), (159), (31)
Clonality
Polyclonal
Conjugate This FGFR1 antibody is un-conjugated
(31), (27), (27), (24), (20), (20), (8), (8), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3)
Application Western Blotting (WB)
(492), (247), (191), (124), (100), (95), (44), (26), (25), (20), (19), (10), (2), (1), (1), (1)
Pubmed 1 reference available
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Product Details anti-FGFR1 Antibody

Target Details FGFR1 Application Details Handling References for anti-FGFR1 Antibody (ABIN374521) Images
Specificity This antibody reacts to CD331.
Cross-Reactivity (Details) Species reactivity (expected):Canine, Bovine.
Species reactivity (tested):Human.
Purification Affinity chromatography
Immunogen Peptide with sequence CLPRHPAQLANGGLKR, from the C Terminus of the protein sequence

Target Details FGFR1

Product Details anti-FGFR1 Antibody Application Details Handling References for anti-FGFR1 Antibody (ABIN374521) Images back to top
Antigen
Alternative Name FGFR1 (FGFR1 Antibody Abstract)
Background FGFR1 (fibroblast growth factor receptor 1) is a member of the fibroblast growth factor receptor family and contains an Ig-like domain and a tyrosine kinase domain. This receptor has multiple isoforms and is a Type I membrane protein. FGFR1 is widely expressed, with distinct isoforms expressed in specific tissues. FGFR1 binds fibroblast growth factor and induces mitogenesis and cellular differentiation. Defects in FGFR1 result in Pfeiffer syndrome associated with craniosynostosis. FGFR1 can be modified by phosphorylation and can bind basic/acidic fibroblast factor depending on the receptor isoform. FGFR1 has been shown to interact with N-cadherin and NCAM. Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides (17-38 kDa) that are potent physiological regulators of growth and differentiation of a wide variety of cells of mesodermal, ectodermal and endodermal origin. FGFs are substantially involved in normal development, wound healing and repair, angiogenesis, a variety of neurotrophic activities, in hematopoiesis as well as in tissue remodeling and maintenance. They also have been implicated in pathological conditions such as tumorigenesis and metastasis. To date, the FGF family consists of at least 23 members designated FGF1 through FGF23. Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR1 [flg-1(fms-like gene 1)], FGFR2 [bek (bacterial expressed kinase gene product)], FGFR3 (cek-2), and FGFR4. Multiple additional variants (isoforms) arising by alternative splicing have been reported: soluble, secreted, or possibly cleaved forms of FGFR1 and FGFR2 have also been found in body fluids or were artificially constructed, [e.g. a soluble FGF-binding protein containing the extracellular region of FGFR1 and the secreted form of placental alkaline phosphatase (FRAP1)]. FGFRs are members of the tyrosine kinase family of growth factor receptors. They are glycosylated 110- 150 kDa proteins that are constructed of an extracellular ligand binding region with either two (alpha type) or typically three (alpha type) immunoglbulin (Ig)-like domains and an eight amino acid acidic box, a transmembrane region, and a cytoplasmic split tyrosine kinase domain that is activated following ligand binding and receptor dimerization. The ligand binding site of FGFRs is confined to the extracellular Ig-like domains 2 and 3. FGFRs exhibit overlapping recognition and redundant specificity. One receptor type may bind with a similar affinity several of the FGFs. Also one FGF type may bind similarly to several distinct receptors. This accounts for the rather identical effects of different FGF ligands on common cell types. FGF's binding to cellular FGFRs depend on or is markedly facilitated by the low-affinity interaction of FGF with the polysaccharide component of the cell surface or extracellular matrix heparan sulfate proteoglycans (HSPG). For example, perlecan, a basement membrane HSPG, promotes high affinity binding of FGF2 in vitro and angiogenesis in vivo. Signal transduction by FGFRs requires dimerization or oligomerization and autophosphorylation of the receptors through their tyrosine kinase domain. Subsequent association with cytoplasmic signaling molecules leads to DNA synthesis or differentiation. The signaling and biological responses elicited by distinct FGFRs substantially differ and are dictated by the intracellular domain. At the mRNA level, FGFR1 is highly expressed in developing human tissues including the brain (preferentially in neurons), vascular basement membranes, skin, and bone growth plates. It may be found in most anchorage dependent cells on their membrane and also may be localized around and in nuclei. Pfeiffer syndrome, as well as other disorders of human skeletal development, is the result of a mutation in the extracellular domain of FGFR1.Synonyms: BFGFR, Basic fibroblast growth factor receptor 1, CEK, FGFBR, FLG, FLT-2, FLT2, Fibroblast growth factor receptor 1, Fms-like tyrosine kinase 2, HBGFR, N-sam, Proto-oncogene c-Fgr, bFGF-R-1
Gene ID 2260, 9606
UniProt P11362
Research Area Cancer, Growth Factors, Tyrosine Kinases, Angiogenesis, Cytokines, Receptors
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway

Application Details

Product Details anti-FGFR1 Antibody Target Details FGFR1 Handling References for anti-FGFR1 Antibody (ABIN374521) Images back to top
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.3 - 1 μg/mL. Immunohistochemistry on paraffin sections: 4 - 6 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-FGFR1 Antibody Target Details FGFR1 Application Details References for anti-FGFR1 Antibody (ABIN374521) Images back to top
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-FGFR1 Antibody (ABIN374521)

Product Details anti-FGFR1 Antibody Target Details FGFR1 Application Details Handling Images back to top
Background publications

Torry, Mukherjea, Arroyo, Torry: "Expression and function of placenta growth factor: implications for abnormal placentation." in: Journal of the Society for Gynecologic Investigation, Vol. 10, Issue 4, pp. 178-88, 2003

Images

Product Details anti-FGFR1 Antibody Target Details FGFR1 Application Details Handling References for anti-FGFR1 Antibody (ABIN374521) back to top
Supplier Images
 image for anti-FGFR1 antibody (Fibroblast Growth Factor Receptor 1) (C-Term) (ABIN374521) anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (C-Term) antibody
 image for anti-FGFR1 antibody (Fibroblast Growth Factor Receptor 1) (C-Term) (ABIN374521) anti-Fibroblast Growth Factor Receptor 1 (FGFR1) (C-Term) antibody (Image 2)