Browse our FGFR4 Proteins (FGFR4)

Full name:
Fibroblast Growth Factor Receptor 4 Proteins (FGFR4)
On are 48 Fibroblast Growth Factor Receptor 4 (FGFR4) Proteins from 15 different suppliers available. Additionally we are shipping FGFR4 Antibodies (211) and FGFR4 Kits (18) and many more products for this protein. A total of 296 FGFR4 products are currently listed.
CD334, etID309818.21, Fgfr-4, fgfr-4c, fgfr4, JTK2, TKF, wu:fc13h10, XFGFR-4, XFGFR-4a, xfgfr4, zgc:111935
list all proteins Gene Name GeneID UniProt
FGFR4 2264 P22455
FGFR4 14186 Q03142
FGFR4 25114 Q498D6

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FGFR4 Proteins (FGFR4) by Origin

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Top referenced FGFR4 Proteins

  1. Rhesus Monkey FGFR4 Protein expressed in Human Cells - ABIN2009898 : Marics, Padilla, Guillemot, Scaal, Marcelle: FGFR4 signaling is a necessary step in limb muscle differentiation. in Development (Cambridge, England) 2002 (PubMed)
    Show all 4 references for 2009898

  2. Rhesus Monkey FGFR4 Protein expressed in Human Cells - ABIN2009903 : Partanen, Mäkelä, Eerola, Korhonen, Hirvonen, Claesson-Welsh, Alitalo: FGFR-4, a novel acidic fibroblast growth factor receptor with a distinct expression pattern. in The EMBO journal 1991 (PubMed)
    Show all 4 references for 2009903

  3. Human FGFR4 Protein expressed in Human Cells - ABIN2003019 : Ron, Reich, Chedid, Lengel, Cohen, Chan, Neufeld, Miki, Tronick: Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor. in The Journal of biological chemistry 1993 (PubMed)
    Show all 4 references for 2003019

  4. Rat (Rattus) FGFR4 Protein expressed in Human Cells - ABIN2009147 : Bange, Prechtl, Cheburkin, Specht, Harbeck, Schmitt, Knyazeva, Müller, Gärtner, Sures, Wang, Imyanitov, Häring, Knayzev, Iacobelli, Höfler, Ullrich: Cancer progression and tumor cell motility are associated with the FGFR4 Arg(388) allele. in Cancer research 2002 (PubMed)
    Show all 4 references for 2009147

  5. Human FGFR4 Protein expressed in HEK-293 Cells - ABIN2181099 : Wang, Stockton, Ittmann: The fibroblast growth factor receptor-4 Arg388 allele is associated with prostate cancer initiation and progression. in Clinical cancer research : an official journal of the American Association for Cancer Research 2004 (PubMed)

More Proteins for FGFR4 Interaction Partners

Cow (Bovine) Fibroblast Growth Factor Receptor 4 (FGFR4) interaction partners

  1. Alterations in the expression of VEGF-A (show VEGFA Proteins) and bFGF (show FGF2 Proteins) systems suggest that angiogenic factors are involved in abnormal placental development in cloned gestations, contributing to impaired fetal development and poor survival rates.

Human Fibroblast Growth Factor Receptor 4 (FGFR4) interaction partners

  1. Enhanced myocardial expression of FGFR4 is associated with left ventricular hypertrophy in chronic kidney disease.

  2. These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1 (show FGF1 Proteins)/fibroblast growth factor receptor 4 signaling in the progression of ovarian cancer. the expression level of Snail1 (show SNAI1 Proteins) and MMP3 (show MMP3 Proteins) was reduced, while the expression level of E-cadherin (show CDH1 Proteins) increased

  3. High FGFR4 expression was significantly associated with the depth of invasion, lymph-node metastasis, pathological stage, and distant metastasis or recurrent disease in gastric cancer.

  4. This study showed that Gly388Arg FGFR4 Polymorphism Is Not Predictive of Everolimus Efficacy in Well-Differentiated Digestive Neuroendocrine Tumors.

  5. Data suggest that knockdown of fibroblast growth factor receptor 4 (FGFR4) expression might prevent the growth of astric cancer (GC) in vivo.

  6. FGFR4 is overexpressed in oral squamous cell carcinoma (OSCC) and oropharyngeal squamous cell carcinoma (OPSCC) in the absence of gene amplification, and may serve as a potential predictive marker for FGFR4-directed targeted therapy in OSCC and OPSCC.

  7. analysis of FGFR3 (show FGFR3 Proteins) and FGFR4 gene polymorphisms in breast cancer in Chinese women of Heilongjiang province reveals that SNPs rs1966265 and rs351855 in FGFR4 , but not rs2234909 and rs3135848 in FGFR3 (show FGFR3 Proteins) are associated with breast cancer

  8. Study shows that FGF19 (show FGF19 Proteins) can be secreted and promotes ovarian cancer progression such as proliferation and invasion by activating FGFR4.

  9. The FGFR4 single-nucleotide polymorphism rs376618 had borderline significant differences in Patients With Primary Bile Acid Diarrhea.

  10. Our study provides the first evidence of a role for FGFR4 in neuroblastoma (show ARHGEF16 Proteins)

Mouse (Murine) Fibroblast Growth Factor Receptor 4 (FGFR4) interaction partners

  1. Blocking FGFR4 inhibits cardiac calcineurin (show PPP3CA Proteins)/NFAT (show NFATC1 Proteins) signaling and attenuates the development of LVH and cardiac fibrosis in a well-established animal model of CKD without significantly altering kidney function, blood pressure, or FGF23 (show FGF23 Proteins) levels.

  2. The FGFR4 transmembrane polymorphic variants can modulate cellular growth and sensitivity to glucocorticoid hormone negative feedback.

  3. FGFR4 deficiency in mice leads to improvement in glucose metabolism, insulin (show INS Proteins) sensitivity, and reduction in body weight under high fat conditions.

  4. The FGFR4-R388 allele yields a receptor variant that preferentially promotes STAT3 (show STAT3 Proteins)/5 signaling.

  5. study shows FGFR4 is specifically up regulated by PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins); however this FGFR4 over expression does not contribute to PAX3 (show PAX3 Proteins)-FOXO1 (show FOXO1 Proteins) tumorigenic phenotypes in primary skeletal muscle myoblasts

  6. findings suggest a modulatory role for FGFR4 in the development and progression of hepatocellular carcinoma and that FGFR4 may be an important and novel therapeutic target in treating this disease

  7. Differential specificity of endocrine FGF19 (show FGF19 Proteins) and FGF21 (show FGF21 Proteins) to FGFR1 (show FGFR1 Proteins) and FGFR4 in complex with KLB (show KLB Proteins).

  8. FGFR3 (show FGFR3 Proteins) and 4 are the receptors that regulate serum 1,25(OH)(2)Vitamin D(3) levels in response to FGF23 (show FGF23 Proteins).

  9. FGFR4 activation mediates the induction of hepatocyte proliferation and the suppression of bile acid biosynthesis by FGF19 (show FGF19 Proteins).

  10. These studies suggest that FGFR1 (show FGFR1 Proteins), FGFR3 (show FGFR3 Proteins), and FGFR4 act in concert to mediate FGF23 (show FGF23 Proteins) effects on the kidney and that loss of FGFR (show FGFR2 Proteins) function leads to feedback stimulation of Fgf23 (show FGF23 Proteins) expression in bone

Zebrafish Fibroblast Growth Factor Receptor 4 (FGFR4) interaction partners

  1. Fgfr4 mediates a signal-transduction pathway between Wnt16 (show WNT16 Proteins) and Dlc, but not Dld, to regulate haematopoietic stem cells specification.

  2. The analysis of receptor-ligand interactions between D. rerio fgf8 (show FGF8 Proteins) and its receptors, fgfr1 (show FGFR1 Proteins) and fgfr4, using combined spectroscopy methods are reported.

FGFR4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

Alternative names and synonyms associated with FGFR4

  • fibroblast growth factor receptor 4 (FGFR4)
  • fibroblast growth factor receptor 4 (fgfr4)
  • fibroblast growth factor receptor 4 (Fgfr4)
  • fibroblast growth factor receptor 4 (fgfr4-b)
  • CD334 protein
  • etID309818.21 protein
  • Fgfr-4 protein
  • fgfr-4c protein
  • fgfr4 protein
  • JTK2 protein
  • TKF protein
  • wu:fc13h10 protein
  • XFGFR-4 protein
  • XFGFR-4a protein
  • xfgfr4 protein
  • zgc:111935 protein

Protein level used designations for FGFR4

fibroblast growth factor receptor 4 , FGF receptor 4 , FGFR-4 , hydroxyaryl-protein kinase , protein-tyrosine kinase , tyrosine kinase related to fibroblast growth factor receptor , tyrosylprotein kinase , CTLA-2-beta protein , fibroblast growth factor receptor 4 16 minus form , protein-tyrosine kinase receptor MPK-11 , fibroblast growth factor receptor FREK , fibroblast growth factor receptor-like embryonic kinase , fibroblast growth factor receptor 4c

317696 Bos taurus
462301 Pan troglodytes
489095 Canis lupus familiaris
549077 Xenopus (Silurana) tropicalis
698494 Macaca mulatta
100477678 Ailuropoda melanoleuca
100582351 Nomascus leucogenys
2264 Homo sapiens
14186 Mus musculus
25114 Rattus norvegicus
100127133 Sus scrofa
395603 Gallus gallus
100355275 Oryctolagus cuniculus
100733523 Cavia porcellus
100000160 Danio rerio
398181 Xenopus laevis
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