anti-Mouse (Murine) HER2 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended HER2 Antibody (supplied by: Log in to see )

Antigen
V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
  • CD340
  • HER-2
  • HER-2/neu
  • HER2
  • MLN 19
  • NEU
  • NGL
  • TKR1
  • Erbb-2
  • Neu
  • c-erbB2
  • c-neu
  • mKIAA3023
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
  • v-erb-b2 avian erythroblastic leukemia viral oncogene 2
  • v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
  • ERBB2
  • Erbb2
Epitope
AA 660-700, pThr686
101
95
72
69
61
58
55
55
48
35
26
22
21
21
21
20
20
20
20
20
20
20
20
20
19
19
19
17
17
15
14
13
13
12
11
8
8
8
8
8
7
7
6
6
5
5
5
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
1386
501
324
36
34
15
13
8
6
5
4
3
3
3
2
1
1
1
1
1
Host
Rabbit
1006
523
38
16
13
5
1
Clonality
Polyclonal
Conjugate
This HER2 antibody is un-conjugated
76
66
59
55
47
41
21
21
14
14
13
12
12
9
8
8
8
8
8
7
7
7
7
7
7
7
7
6
3
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
720
602
334
321
309
309
268
134
112
101
91
22
21
19
8
6
6
5
5
3
3
2
1
1
1
1
1
1
1
Options
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Catalog No. ABIN752398
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN752401 IF (p) Cy3 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN752402 IF (p) Cy5 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN752403 IF (p) Cy5.5 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN752404 IF (p) Cy7 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN752405 IF (p) FITC Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN880020 IF (p) Alexa Fluor 647 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN880023 IF (p) Alexa Fluor 488 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN880019 IF (p) Alexa Fluor 555 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN880022 IF (p) Alexa Fluor 350 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN2814275 IF (p) Alexa Fluor 594 Rabbit IgG AA 660-700, pThr686 Log in to see Polyclonal
1 ABIN742948 IF (p) Cy5.5 Rabbit IgG pTyr1221, pTyr1222 Log in to see Polyclonal
1 ABIN742949 IF (p) Cy7 Rabbit IgG pTyr1221, pTyr1222 Log in to see Polyclonal
1 ABIN1708167 IF (p) Cy7 Rabbit IgG pTyr1139 Log in to see Polyclonal
1 ABIN1709392 IF (p) FITC Rabbit IgG pTyr1222 Log in to see Polyclonal
1 ABIN1709391 IF (p) FITC Rabbit IgG pTyr1221 Log in to see Polyclonal
1 ABIN1709978 IF (p) FITC Rabbit IgG pTyr1139 Log in to see Polyclonal
1 ABIN742946 IF (p) Cy3 Rabbit IgG pTyr1221, pTyr1222 Log in to see Polyclonal
1 ABIN742947 IF (p) Cy5 Rabbit IgG pTyr1221, pTyr1222 Log in to see Polyclonal
1 ABIN742950 IF (p) FITC Rabbit IgG pTyr1221, pTyr1222 Log in to see Polyclonal
1 ABIN742977 IF (p) Cy5 Rabbit IgG pTyr1248 Log in to see Polyclonal

General

Antigen V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) Antibodies
Epitope AA 660-700, pThr686
(101), (95), (72), (69), (61), (58), (55), (55), (48), (35), (26), (22), (21), (21), (21), (20), (20), (20), (20), (20), (20), (20), (20), (20), (19), (19), (19), (17), (17), (15), (14), (13), (13), (12), (11), (8), (8), (8), (8), (8), (7), (7), (6), (6), (5), (5), (5), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(1386), (501), (324), (36), (34), (15), (13), (8), (6), (5), (4), (3), (3), (3), (2), (1), (1), (1), (1), (1)
Host Rabbit
(1006), (523), (38), (16), (13), (5), (1)
Clonality
Polyclonal
Conjugate This HER2 antibody is un-conjugated
(76), (66), (59), (55), (47), (41), (21), (21), (14), (14), (13), (12), (12), (9), (8), (8), (8), (8), (8), (7), (7), (7), (7), (7), (7), (7), (7), (6), (3), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(720), (602), (334), (321), (309), (309), (268), (134), (112), (101), (91), (22), (21), (19), (8), (6), (6), (5), (5), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1)
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Product Details anti-HER2 Antibody

Target Details HER2 Application Details Handling Images
Specificity This phosphorylation site is homologous to that of Thr687 in Mouse and Thr688 in Rat.
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Thr686
Isotype IgG

Target Details HER2

Product Details anti-HER2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Her2 (ERBB2 Antibody Abstract)
Background

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A, the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

Subcellular location: Cytoplasm

Synonyms: NEU, NGL, HER2, TKR1, CD340, HER-2, MLN 19, HER-2/neu, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, ERBB2, MLN19

Gene ID 2064
UniProt P04626
Pathways RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development

Application Details

Product Details anti-HER2 Antibody Target Details HER2 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-HER2 Antibody Target Details HER2 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-HER2 Antibody Target Details HER2 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-V-Erb-B2 erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) (ERBB2) (AA 660-700), (pThr686) antibody (ABIN752398) Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti Phospho-HE...