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|Application / Reactivity||Rat (Rattus)||Mouse (Murine)||Human|
|ELISA||15 Antibodies||17 Antibodies||72 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies||3 Antibodies||5 Antibodies|
|Immunofluorescence (IF)||2 Antibodies||1 Antibodies|
|Immunohistochemistry (IHC)||13 Antibodies||14 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||6 Antibodies||6 Antibodies|
|Western Blotting (WB)||23 Antibodies||26 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Flow Cytometry (FACS)||16 Antibodies|
|Antigen||PTK7 Protein tyrosine Kinase 7 (PTK7) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This PTK7 antibody is un-conjugated Alternatives|
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
|4 references available|
|Supplier||Log in to see|
Product Details anti-PTK7 AntibodyTarget Details PTK7 Application Details Handling References for anti-PTK7 Antibody (ABIN1003048) Images
|Blocking Peptide||Blocking peptide for this product available: ABIN1003850|
|Purification||Affinity chromatography purified via peptide column.|
|Immunogen||PTK7 antibody was raised in rabbits against an 18 amino acid peptide from near the carboxy terminus of human PTK7.|
Target Details PTK7Product Details anti-PTK7 Antibody Application Details Handling References for anti-PTK7 Antibody (ABIN1003048) Images back to top
|Alternative Name||PTK7 (PTK7 Antibody Abstract)|
|Background||Protein-tyrosine kinases (PTKs) play important roles in regulating cell proliferation and differentiation during development. One member of the PTK family, PTK7, has been suggested to regulate the planar cell polarity (PCP) pathway in vertebrates and may play a role in neural convergent extension and neural tube closure. PTK7 has also been implicated in the development of cancer. Loss of PTK7 expression was seen in several melanoma cell lines and biopsies. Conversely, high-throughput analysis of acute myeloid leukemia samples showed an increased level of PTK7 expression compared to normal bone marrow and purified CD34+ cells. Multiple isoforms of PTK7 are known to exist.|
Application DetailsProduct Details anti-PTK7 Antibody Target Details PTK7 Handling References for anti-PTK7 Antibody (ABIN1003048) Images back to top
|Application Notes||PTK7 antibody can be used for detection of PTK7 by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PTK7 Antibody Target Details PTK7 Application Details References for anti-PTK7 Antibody (ABIN1003048) Images back to top
|Buffer||Antibody is supplied in PBS containing 0.02% sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.|
|Expiry Date||12 months|
References for anti-PTK7 Antibody (ABIN1003048)Product Details anti-PTK7 Antibody Target Details PTK7 Application Details Handling Images back to top
|Product cited in:||
Lu, Borchers, Jolicoeur et al.: "PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates." in: Nature, Vol. 430, Issue 6995, pp. 93-8, 2004 (PubMed).
Müller-Tidow, Schwäble, Steffen et al.: "High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targets." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 10, Issue 4, pp. 1241-9, 2004 (PubMed).
Easty, Mitchell, Patel et al.: "Loss of expression of receptor tyrosine kinase family genes PTK7 and SEK in metastatic melanoma." in: International journal of cancer. Journal international du cancer, Vol. 71, Issue 6, pp. 1061-5, 1997 (PubMed).
Park, Lee, Lee: "Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG." in: Journal of biochemistry, Vol. 119, Issue 2, pp. 235-9, 1997 (PubMed).