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|Antigen||Ret Proto-Oncogene (RET) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This Ret Proto-Oncogene antibody is un-conjugated Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
Product Details anti-Ret Proto-Oncogene AntibodyTarget Details Ret Proto-Oncogene Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human Ret/HSCR1|
Target Details Ret Proto-OncogeneProduct Details anti-Ret Proto-Oncogene Antibody Application Details Handling Images back to top
|Alternative Name||Ret (RET Antibody Abstract)|
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq, Jul 2008].
Subcellular location: Cytoplasm
Synonyms: C ret, Cadherin family member 12, CDHF 12, CDHF12, ELKS Fusion gene, HSCR 1, HSCR1, Hydroxyaryl protein kinase, MEN2A, MEN2B, MTC 1, MTC1, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, Proto oncogene tyrosine protein kinase receptor ret, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor ret, PTC, RET, RET ELE1, Ret Proto oncogene, RET transforming sequence, RET_HUMAN, RET51.
|Research Area||Cancer, Tyrosine Kinases, Signaling, Kinases/Phosphatases|
|Pathways||RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation|
Application DetailsProduct Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Handling Images back to top
|Restrictions||For Research Use only|
HandlingProduct Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at -20°C|
|Expiry Date||12 months|
ImagesProduct Details anti-Ret Proto-Oncogene Antibody Target Details Ret Proto-Oncogene Application Details Handling back to top