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Browse our TEK Proteins (TEK)

Full name:
TEK Tyrosine Kinase, Endothelial Proteins (TEK)
On www.antibodies-online.com are 40 TEK Tyrosine Kinase, Endothelial (TEK) Proteins from 10 different suppliers available. Additionally we are shipping TEK Antibodies (378) and TEK Kits (68) and many more products for this protein. A total of 505 TEK products are currently listed.
Synonyms:
AA517024, CD202B, DKFZp469E064, Hyk, TEK, Tie-2, tie2, VMCM, VMCM1
list all proteins Gene Name GeneID UniProt
TEK 21687  
TEK 7010 Q02763
TEK 89804  

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TEK Proteins (TEK) by Origin

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Top referenced TEK Proteins

  1. Mouse (Murine) TEK Protein expressed in Baculovirus infected Insect Cells - ABIN2008584 : Partanen, Armstrong, Mäkelä, Korhonen, Sandberg, Renkonen, Knuutila, Huebner, Alitalo: A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. in Molecular and cellular biology 1992 (PubMed)
    Show all 5 references for ABIN2008584

  2. Mouse (Murine) TEK Protein expressed in Human Cells - ABIN2008582 : Sato, Qin, Kozak, Audus: Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 5 references for ABIN2008582

  3. Cynomolgus TEK Protein expressed in Human Cells - ABIN2010105 : Jones, Master, Jones, Bouchard, Gunji, Sasaki, Daly, Alitalo, Dumont: Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN2010105

  4. Human TEK Protein expressed in Baculovirus infected Insect Cells - ABIN2003268 : Fukuhara, Sako, Minami, Noda, Kim, Kodama, Shibuya, Takakura, Koh, Mochizuki: Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. in Nature cell biology 2008 (PubMed)
    Show all 5 references for ABIN2003268

  5. Rat (Rattus) TEK Protein expressed in Human Cells - ABIN2009109 : Marron, Singh, Tahir, Kavumkal, Kim, Koh, Brindle: Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. in The Journal of biological chemistry 2007 (PubMed)
    Show all 4 references for ABIN2009109

More Proteins for TEK Interaction Partners

Mouse (Murine) TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. results implicate common genetic variation at the TIE2 locus as a determinant of vascular leak-related clinical outcomes from common infections, suggesting new tools to identify individuals at unusual risk for deleterious complications of infection

  2. the results suggest that an increased level of TNF-alpha (show TNF Proteins) together with concomitant upregulation of Tie2/Angiopoietin signaling have critical roles in severe dengue infection.

  3. Data support an interactive model of Tie1 (show TIE1 Proteins) and Tie2 function, in which dynamically regulated Tie1 (show TIE1 Proteins) versus Tie2 expression determines the net positive or negative effect of Tie1 (show TIE1 Proteins) on Tie2 signaling.

  4. These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Proteins).

  5. Report accelerated lung regeneration by platelet-rich plasma extract through Lrp5 (show LRP5 Proteins)/Tie2 pathway.

  6. Rapamycin improves TIE2-mutated venous malformation

  7. an EPC (show TCF21 Proteins) SDF-1 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) axis plays an important role in bone fracture healing using Tie2-Cre(ER) CXCR4 (show CXCR4 Proteins) conditional knockout mice.

  8. Immunohistological analysis of the tumors showed that Tie2-dependent a6 gene deletion was associated with reduced tumor vascularization and with reduced infiltration of proangiogenic Tie2-expressing macrophages

  9. These results suggest that PRP extract prevents endotoxin-induced pulmonary edema mainly through Ang (show ANG Proteins)-Tie2 signaling, and PRP extract could be a potential therapeutic strategy for sepsis-induced pulmonary edema

  10. VE-PTP (show PTPRB Proteins) activates TIE2 and stabilizes retinal and choroidal blood vessels

Human TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. pro-angiogenic Tie-2-expressing monocytes (TEM (show CYLD Proteins)) and endothelial progenitor cells (EPC (show TCF21 Proteins)) play a crucial role in Critical limb ischemia.

  2. dysregulation of the angiopoietin (Angpt)/Tie2 ligand (show ANGPT2 Proteins) receptor system may be crucial for endothelial dysfunction in hemolytic uremic syndrome

  3. we report the analysis of a comprehensive collection of 22 TIE2 mutations identified in patients with vascular morphogenesis

  4. The inhibition of Tie-2 exerted by Tie-1can be relieved by Tie-1 (show TIE1 Proteins) ectodomain cleavage mediated by tumor- and inflammatory-related factors, which causes destabilization of vessels and initiates vessel remodeling in cancer. (Review)

  5. These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Proteins).

  6. we show that VEGFA (show VEGFA Proteins) signaling from TIE2(hi) TMEM macrophages results in local, transient vascular permeability and tumor cell intravasation.

  7. In the absence of Tie-2, VE-PTP (show PTPRB Proteins) inhibition destabilizes endothelial barrier integrity in agreement with the VE-cadherin (show CDH5 Proteins)-supportive effect of VE-PTP (show PTPRB Proteins).

  8. Data indicate that foretinib suppresses angiogenesis and lymphangiogenesis by blocking vascular endothelial growth factor receptors

  9. Genetic variation contributes to the interindividual variation in growth factor levels and explains a modest proportion of circulating hepatocyte growth factor (show HGF Proteins), Ang-2 (show ANGPT2 Proteins), and Tie-2.

  10. Data indicate that vascular malformations (VMs) are mediated by mutations in receptor tyrosine kinase (show RET Proteins) Tie2 (TEK).

Zebrafish TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. observations demonstrate that Tie2 is an important regulator of tip cell behaviors

  2. Tie-1 (show TIE1 Proteins) and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.

TEK Protein Profile

Protein Summary

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations\; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Alternative names and synonyms associated with TEK

  • TEK tyrosine kinase, endothelial (TEK)
  • TEK tyrosine kinase, endothelial (LOC100356675)
  • TEK tyrosine kinase, endothelial (tek)
  • endothelial-specific receptor tyrosine kinase (Tek)
  • TEK tyrosine kinase, endothelial (Tek)
  • AA517024 protein
  • CD202B protein
  • DKFZp469E064 protein
  • Hyk protein
  • TEK protein
  • Tie-2 protein
  • tie2 protein
  • VMCM protein
  • VMCM1 protein

Protein level used designations for TEK

growth factor receptor Tie2/Tek , TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) , Angiopoietin-1 receptor , TEK tyrosine kinase, endothelial , angiopoietin-1 receptor-like , STK1 , angiopoietin-1 receptor , endothelial tyrosine kinase , mTIE2 , p140 TEK , tunica interna endothelial cell kinase , tyrosine kinase with Ig and EGF homology domains-2 , tyrosine-protein kinase receptor TEK , tyrosine-protein kinase receptor TIE-2 , hTIE2 , soluble TIE2 variant 1 , soluble TIE2 variant 2 , protein-tyrosine kinase Tie2 , endothelial-specific receptor tyrosine kinase , tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2 , endothelium-specific receptor tyrosine kinase 2 , tyrosine-protein kinase receptor Tie-2

GENE ID SPECIES
403714 Canis lupus familiaris
465028 Pan troglodytes
707455 Macaca mulatta
100174302 Pongo abelii
100356675 Oryctolagus cuniculus
100408334 Callithrix jacchus
100492432 Xenopus (Silurana) tropicalis
100606897 Nomascus leucogenys
21687 Mus musculus
7010 Homo sapiens
396729 Sus scrofa
89804 Rattus norvegicus
280939 Bos taurus
30747 Danio rerio
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