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Browse our TEK Proteins (TEK)

Full name:
TEK Tyrosine Kinase, Endothelial Proteins (TEK)
On are 40 TEK Tyrosine Kinase, Endothelial (TEK) Proteins from 10 different suppliers available. Additionally we are shipping TEK Antibodies (392) and TEK Kits (69) and many more products for this protein. A total of 521 TEK products are currently listed.
AA517024, CD202B, DKFZp469E064, Hyk, TEK, Tie-2, tie2, VMCM, VMCM1
list all proteins Gene Name GeneID UniProt
TEK 21687  
TEK 7010 Q02763
TEK 89804  

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TEK Proteins (TEK) by Origin

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Top referenced TEK Proteins

  1. Mouse (Murine) TEK Protein expressed in Baculovirus infected Insect Cells - ABIN2008584 : Partanen, Armstrong, Mäkelä, Korhonen, Sandberg, Renkonen, Knuutila, Huebner, Alitalo: A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. in Molecular and cellular biology 1992 (PubMed)
    Show all 5 references for ABIN2008584

  2. Human TEK Protein expressed in Baculovirus infected Insect Cells - ABIN2003268 : Sato, Qin, Kozak, Audus: Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 5 references for ABIN2003268

  3. Mouse (Murine) TEK Protein expressed in Human Cells - ABIN2008582 : Jones, Master, Jones, Bouchard, Gunji, Sasaki, Daly, Alitalo, Dumont: Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for ABIN2008582

  4. Cynomolgus TEK Protein expressed in Human Cells - ABIN2010105 : Fukuhara, Sako, Minami, Noda, Kim, Kodama, Shibuya, Takakura, Koh, Mochizuki: Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. in Nature cell biology 2008 (PubMed)
    Show all 5 references for ABIN2010105

  5. Rat (Rattus) TEK Protein expressed in Human Cells - ABIN2009109 : Marron, Singh, Tahir, Kavumkal, Kim, Koh, Brindle: Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. in The Journal of biological chemistry 2007 (PubMed)
    Show all 4 references for ABIN2009109

More Proteins for TEK Interaction Partners

Mouse (Murine) TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoi (show ANGPT1 Proteins)etin 1/ Tie-2 signaling pathway.

  2. TBMS1 further stimulated the proteasomal degradation of vascular endothelial growth factor receptor-2 (VEGFR2 (show KDR Proteins)) and Tie2 in endothelial cells, which down-regulated AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling.

  3. results implicate common genetic variation at the TIE2 locus as a determinant of vascular leak-related clinical outcomes from common infections, suggesting new tools to identify individuals at unusual risk for deleterious complications of infection

  4. the results suggest that an increased level of TNF-alpha (show TNF Proteins) together with concomitant upregulation of Tie2/Angiopoietin signaling have critical roles in severe dengue infection.

  5. Data support an interactive model of Tie1 (show TIE1 Proteins) and Tie2 function, in which dynamically regulated Tie1 (show TIE1 Proteins) versus Tie2 expression determines the net positive or negative effect of Tie1 (show TIE1 Proteins) on Tie2 signaling.

  6. These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Proteins).

  7. Report accelerated lung regeneration by platelet-rich plasma extract through Lrp5 (show LRP5 Proteins)/Tie2 pathway.

  8. Rapamycin improves TIE2-mutated venous malformation

  9. an EPC (show TCF21 Proteins) SDF-1 (show CXCL12 Proteins)/CXCR4 (show CXCR4 Proteins) axis plays an important role in bone fracture healing using Tie2-Cre(ER) CXCR4 (show CXCR4 Proteins) conditional knockout mice.

  10. Immunohistological analysis of the tumors showed that Tie2-dependent a6 gene deletion was associated with reduced tumor vascularization and with reduced infiltration of proangiogenic Tie2-expressing macrophages

Human TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (show ANGPT2 Proteins) Ang-1 (show ANGPT1 Proteins), but not the receptor binding domain of Ang-2 (show ANGPT2 Proteins), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (show MAPK1 Proteins) signaling in the presence of both Ang-1 (show ANGPT1 Proteins) and fibronectin (show FN1 Proteins)

  2. Activation of Tie2 by subcutaneous injections of AKB-9778 combined with suppression of vascular endothelial growth factor (VEGF) causes a significantly greater reduction in Diabetic macular edema than that seen with suppression of VEGF alone.

  3. We could therefore conclude that angiogenesis is an important event in the development of common skin warts, and the upregulation of both Ang1 (show ANGPT1 Proteins) and -2 and their binding receptor Tie2 may play a role in the angiogenesis associated with the development of these lesions.

  4. Calcium/calmodulin (show CALM1 Proteins)-dependent negative regulation of Tie2 can be used as an inhibitory signal for vessel growth and branching to build proper vessel architecture during embryonic development.

  5. Tie2 in combination with Ca125 (show MUC16 Proteins) provides superior information to clinicians on progressive disease in patients with VEGFi-treated ovarian cancers

  6. Hydroxysafflor yellow A promotes angiogenesis in HUVEC cells via the angiopoietin 1 (show ANGPT1 Proteins)/ Tie-2 signaling pathway.

  7. These results suggest that COMP (show COMP Proteins)-Ang1 (show ANGPT1 Proteins) enhances survival and proliferation of human PLFs through the activation of Tie2-mediated signaling, where PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) and MAPK (show MAPK1 Proteins)-c-Jun (show JUN Proteins) signaling pathways act as downstream effectors.

  8. Exercise therapy increased levels of proangiogenic TIE-2 monocytes and circulating angiogenic cells in patients with peripheral arterial disease.

  9. These results suggested that IL-35 restrains rheumatoid arthritis angiogenesis and inflammation by downregulating basal and VEGF (show VEGFA Proteins)-induced Ang2 (show ANGPT2 Proteins) secretion as well as disrupting Ang2 (show ANGPT2 Proteins)/Tie2 signal transduction.

  10. High Ang 1 expression in hilar cholangiocarcinoma and infiltration of TIE2-expressing monocytes (TEMs) defines a subgroup of patients with beneficial tumor characteristics and prolonged survival. Low Ang 2 levels tended to inversely correlate with TEMs invasion.

Cow (Bovine) TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.

Zebrafish TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. observations demonstrate that Tie2 is an important regulator of tip cell behaviors

  2. Tie-1 (show TIE1 Proteins) and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.

TEK Protein Profile

Protein Summary

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations\; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Alternative names and synonyms associated with TEK

  • TEK tyrosine kinase, endothelial (TEK)
  • TEK tyrosine kinase, endothelial (LOC100356675)
  • TEK tyrosine kinase, endothelial (tek)
  • endothelial-specific receptor tyrosine kinase (Tek)
  • TEK tyrosine kinase, endothelial (Tek)
  • AA517024 protein
  • CD202B protein
  • DKFZp469E064 protein
  • Hyk protein
  • TEK protein
  • Tie-2 protein
  • tie2 protein
  • VMCM protein
  • VMCM1 protein

Protein level used designations for TEK

growth factor receptor Tie2/Tek , TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) , Angiopoietin-1 receptor , TEK tyrosine kinase, endothelial , angiopoietin-1 receptor-like , STK1 , angiopoietin-1 receptor , endothelial tyrosine kinase , mTIE2 , p140 TEK , tunica interna endothelial cell kinase , tyrosine kinase with Ig and EGF homology domains-2 , tyrosine-protein kinase receptor TEK , tyrosine-protein kinase receptor TIE-2 , hTIE2 , soluble TIE2 variant 1 , soluble TIE2 variant 2 , protein-tyrosine kinase Tie2 , endothelial-specific receptor tyrosine kinase , tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2 , endothelium-specific receptor tyrosine kinase 2 , tyrosine-protein kinase receptor Tie-2

403714 Canis lupus familiaris
465028 Pan troglodytes
707455 Macaca mulatta
100174302 Pongo abelii
100356675 Oryctolagus cuniculus
100408334 Callithrix jacchus
100492432 Xenopus (Silurana) tropicalis
100606897 Nomascus leucogenys
21687 Mus musculus
7010 Homo sapiens
396729 Sus scrofa
89804 Rattus norvegicus
280939 Bos taurus
30747 Danio rerio
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