Browse our TEK Proteins (TEK)

Full name:
TEK Tyrosine Kinase, Endothelial Proteins (TEK)
On are 42 TEK Tyrosine Kinase, Endothelial (TEK) Proteins from 10 different suppliers available. Additionally we are shipping TEK Antibodies (400) and TEK Kits (70) and many more products for this protein. A total of 532 TEK products are currently listed.
AA517024, CD202B, DKFZp469E064, Hyk, TEK, Tie-2, tie2, VMCM, VMCM1
list all proteins Gene Name GeneID UniProt
TEK 21687  
TEK 7010 Q02763
TEK 89804  

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TEK Proteins (TEK) by Origin

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Top referenced TEK Proteins

  1. Human TEK Protein expressed in Baculovirus infected Insect Cells - ABIN2003268 : Partanen, Armstrong, Mäkelä, Korhonen, Sandberg, Renkonen, Knuutila, Huebner, Alitalo: A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. in Molecular and cellular biology 1992 (PubMed)
    Show all 5 references for 2003268

  2. Mouse (Murine) TEK Protein expressed in Baculovirus infected Insect Cells - ABIN2008584 : Sato, Qin, Kozak, Audus: Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 5 references for 2008584

  3. Mouse (Murine) TEK Protein expressed in Human Cells - ABIN2008582 : Jones, Master, Jones, Bouchard, Gunji, Sasaki, Daly, Alitalo, Dumont: Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. in The Journal of biological chemistry 1999 (PubMed)
    Show all 5 references for 2008582

  4. Cynomolgus TEK Protein expressed in Human Cells - ABIN2010105 : Fukuhara, Sako, Minami, Noda, Kim, Kodama, Shibuya, Takakura, Koh, Mochizuki: Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. in Nature cell biology 2008 (PubMed)
    Show all 5 references for 2010105

  5. Rat (Rattus) TEK Protein expressed in Human Cells - ABIN2009109 : Marron, Singh, Tahir, Kavumkal, Kim, Koh, Brindle: Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. in The Journal of biological chemistry 2007 (PubMed)
    Show all 4 references for 2009109

More Proteins for TEK Interaction Partners

Mouse (Murine) TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. TEK mutations have a role in primary congenital glaucoma with variable expressivity

  2. ANG2 activation of Tie2 supports stable enlargement of normal nonleaky vessels, but reduction of Tie1 in inflammation leads to ANG2 antagonism of Tie2 and initiates a positive feedback loop wherein FOXO1-driven ANG2 expression promotes vascular remodeling and leakage

  3. Hydroxysafflor yellow A promotes angiogenesis in ischemic hindlimb via the angiopoi (show ANGPT1 Proteins)etin 1/ Tie-2 signaling pathway.

  4. TBMS1 further stimulated the proteasomal degradation of vascular endothelial growth factor receptor-2 (VEGFR2 (show KDR Proteins)) and Tie2 in endothelial cells, which down-regulated AKT (show AKT1 Proteins)/mTOR (show FRAP1 Proteins) signaling.

  5. results implicate common genetic variation at the TIE2 locus as a determinant of vascular leak-related clinical outcomes from common infections, suggesting new tools to identify individuals at unusual risk for deleterious complications of infection

  6. the results suggest that an increased level of TNF-alpha (show TNF Proteins) together with concomitant upregulation of Tie2/Angiopoietin signaling have critical roles in severe dengue infection.

  7. Data support an interactive model of Tie1 (show TIE1 Proteins) and Tie2 function, in which dynamically regulated Tie1 (show TIE1 Proteins) versus Tie2 expression determines the net positive or negative effect of Tie1 (show TIE1 Proteins) on Tie2 signaling.

  8. These results suggest that Tie2 signaling induces alpha4beta1 integrin activation on bone marrow-mast cell progenitor for adhesion to VCAM-1 (show VCAM1 Proteins).

  9. Report accelerated lung regeneration by platelet-rich plasma extract through Lrp5 (show LRP5 Proteins)/Tie2 pathway.

  10. Rapamycin improves TIE2-mutated venous malformation

Human TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. TEK mutations have a role in primary congenital glaucoma with variable expressivity

  2. Tie1 directly interacts with Tie2 to promote ANG-induced vascular responses under noninflammatory conditions, whereas in inflammation, Tie1 cleavage contributes to loss of ANG2 agonist activity and vascular stability

  3. ANG-1 (show ANGPT1 Proteins), ANG-2 (show ANGPT2 Proteins) and TIE-2 levels were significantly increased in placenta of non-complicated ART pregnancies compared to placentas from spontaneous conception.

  4. Our data suggest that interaction of TEK and CYP1B1 (show CYP1B1 Proteins) contributes to primary congenital glaucoma pathogenesis and argue that TEK-CYP1B1 (show CYP1B1 Proteins) may perform overlapping as well as distinct functions in manifesting the disease etiology.

  5. High Tie-2 expression is associated with Primary Myelofibrosis.

  6. In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells. Tie-2 expression in tumor cells predicted poorer prognosis.Our data support that dual inhibition of Ang-1 and Ang-2 may be an alternative target for anti-angiogenic adjuvant therapy in advanced or recurrent cervical squamous cell cancer.

  7. Data show that fibulin-5 (show FBLN5 Proteins) strongly binds to the endothelial cell surface reducing endothelial cell viability and interfering with the signaling pathways of the Ang-1 (show ANGPT1 Proteins)/TIE-2 receptor axis.

  8. Blue rubber bleb nevus syndrome cased by somatic mutation of TEK.

  9. Ang (show ANG Proteins),Tie1 (show TIE1 Proteins) and Tie2 play roles in vascular development and pathogenesis of vascular diseases.[review]

  10. In vitro binding assays with purified components reveal that Tie-integrin recognition is direct, and further demonstrate that the receptor binding domain of the Tie2 ligand (show ANGPT2 Proteins) Ang-1 (show ANGPT1 Proteins), but not the receptor binding domain of Ang-2 (show ANGPT2 Proteins), can independently associate with a5b1 or aVb3. cooperative Tie/integrin interactions selectively stimulate ERK/MAPK (show MAPK1 Proteins) signaling in the presence of both Ang-1 (show ANGPT1 Proteins) and fibronectin (show FN1 Proteins)

Cow (Bovine) TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. Angiopoietin-1 receptor Tie2 distinguishes multipotent differentiation capability in bovine coccygeal nucleus pulposus cells.

Zebrafish TEK Tyrosine Kinase, Endothelial (TEK) interaction partners

  1. observations demonstrate that Tie2 is an important regulator of tip cell behaviors

  2. Tie-1 (show TIE1 Proteins) and Tie-2 are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.

TEK Protein Profile

Protein Summary

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations\; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Alternative names and synonyms associated with TEK

  • TEK tyrosine kinase, endothelial (TEK)
  • TEK tyrosine kinase, endothelial (LOC100356675)
  • TEK tyrosine kinase, endothelial (tek)
  • endothelial-specific receptor tyrosine kinase (Tek)
  • TEK tyrosine kinase, endothelial (Tek)
  • AA517024 protein
  • CD202B protein
  • DKFZp469E064 protein
  • Hyk protein
  • TEK protein
  • Tie-2 protein
  • tie2 protein
  • VMCM protein
  • VMCM1 protein

Protein level used designations for TEK

growth factor receptor Tie2/Tek , TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) , Angiopoietin-1 receptor , TEK tyrosine kinase, endothelial , angiopoietin-1 receptor-like , STK1 , angiopoietin-1 receptor , endothelial tyrosine kinase , mTIE2 , p140 TEK , tunica interna endothelial cell kinase , tyrosine kinase with Ig and EGF homology domains-2 , tyrosine-protein kinase receptor TEK , tyrosine-protein kinase receptor TIE-2 , hTIE2 , soluble TIE2 variant 1 , soluble TIE2 variant 2 , protein-tyrosine kinase Tie2 , endothelial-specific receptor tyrosine kinase , tyrosine kinases that contain immunoglobulin-like loops and epidermal growth factor-similar domains 2 , endothelium-specific receptor tyrosine kinase 2 , tyrosine-protein kinase receptor Tie-2

403714 Canis lupus familiaris
465028 Pan troglodytes
707455 Macaca mulatta
100174302 Pongo abelii
100356675 Oryctolagus cuniculus
100408334 Callithrix jacchus
100492432 Xenopus (Silurana) tropicalis
100606897 Nomascus leucogenys
21687 Mus musculus
7010 Homo sapiens
396729 Sus scrofa
89804 Rattus norvegicus
280939 Bos taurus
30747 Danio rerio
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