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Browse our TIE1 Proteins (TIE1)

Full name:
tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 Proteins (TIE1)
On www.antibodies-online.com are 29 tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) Proteins from 9 different suppliers available. Additionally we are shipping TIE1 Antibodies (178) and TIE1 Kits (23) and many more products for this protein. A total of 237 TIE1 products are currently listed.
Synonyms:
D430008P04Rik, JTK14, TIE, tie-1
list all proteins Gene Name GeneID UniProt
TIE1 7075 P35590
TIE1 21846 Q06806
Rat TIE1 TIE1 89806  

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TIE1 Proteins (TIE1) by Origin

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Top referenced TIE1 Proteins

  1. Human TIE1 Protein expressed in Human Cells - ABIN2002975 : Boutet, Quertermous, Fadel: Identification of an octamer element required for in vivo expression of the TIE1 gene in endothelial cells. in The Biochemical journal 2001 (PubMed)

More Proteins for TIE1 Interaction Partners

Zebrafish tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) interaction partners

  1. Expression of a non-phosphorylatable mutant of the Tie1 juxtamembrane domain threonine site (T794A) significantly disrupted vascular development, resulting in fish with stunted and (show TEK Proteins)poorly branched intersomitic vessels.

  2. Tie-1 and Tie-2 (show TEK Proteins) are not required for early heart development, yet they have redundant roles for the maintenance of endocardial-myocardial connection in later stages.

  3. A natural antisense transcript was identified for tyrosine kinase containing immunoglobulin and epidermal growth factor (show EGF Proteins) homology domain-1 (tie-1), tie-1AS long noncoding RNA in zebrafish, mouse, and humans.

Human tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) interaction partners

  1. The inhibition of Tie-2 (show TEK Proteins) exerted by Tie-1can be relieved by Tie-1 ectodomain cleavage mediated by tumor- and inflammatory-related factors, which causes destabilization of vessels and initiates vessel remodeling in cancer. (Review)

  2. T794A-expressing human umbilical vein endothelial cells formed significantly shorter tubes with fewer branches in three-dimensional Matrigel cultures, but did not alter Tie1 or Tie2 (show TEK Proteins) tyrosine phosphorylation or downstream signaling.

  3. The decreasing expression of Tie1 may play an important role in the pathogenesis of primary lower extremity varicose veins.

  4. Data propose that EndMT associated with Tie1 downregulation participates in the pathological development of stroma observed in tumours.

  5. the effects of factors activating ectodomain cleavage on both Tie1 and Tie2 (show TEK Proteins) within the same population of cells, and their impact on angiopoietin signalling

  6. these results suggest that the expression level of Tie1 and its physical interaction with Tie2 defines whether Ang2 functions as a Tie2 agonist or antagonist, thereby determining the context-dependent differential endothelial sensitivity to Ang2.

  7. The Tie-1 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured villi showed immunoreactivity only in other components.

  8. Provide evidence for Tie1-Tie2 (show TEK Proteins) complex formation on the cell surface and identify molecular surface areas essential for recognition. The Tie1-Tie2 (show TEK Proteins) interactions are dynamic, inhibitory, and differentially modulated by angiopoietin-1 (show ANGPT1 Proteins) and -2.

  9. A natural antisense transcript was identified for tyrosine kinase (show TXK Proteins) containing immunoglobulin and epidermal growth factor (show EGF Proteins) homology domain-1 (tie-1), tie-1AS long noncoding RNA in zebrafish, mouse, and humans.

  10. Vascular endothelial growth factor modulates the Tie-2 (show TEK Proteins):Tie-1 receptor complex

Mouse (Murine) tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 (TIE1) interaction partners

  1. Data support an interactive model of Tie1 and Tie2 (show TEK Proteins) function, in which dynamically regulated Tie1 versus Tie2 (show TEK Proteins) expression determines the net positive or negative effect of Tie1 on Tie2 (show TEK Proteins) signaling.

  2. Data indicate that receptor tyrosine kinase (show ERBB3 Proteins) Tie1 deletion resulted in lack of lymphatic valves and collecting vessel defects.

  3. In contrast to the important role of Tie2 (show TEK Proteins) in the regulation of blood vascular development, Tie1 is crucial in the process of lymphatic remodeling and maturation, which is independent of Tie2 (show TEK Proteins).

  4. Tie1 regulates tumor angiogenesis, postnatal sprouting angiogenesis, and endothelial cell survival, which are controlled by VEGF (show VEGFA Proteins), Angpt, and Notch (show NOTCH1 Proteins) signals

  5. Shear stress conditions that modulate atherogenic events also regulate Tie1 expression. Therefore, Tie1 may play a novel proinflammatory role in atherosclerosis.

  6. Developing lymphatic vasculature is particularly sensitive to alterations in Tie1 expression in mice.

  7. Loss of Tie1 results in lymphatic vascular abnormalities that precede the blood vessel phenotype, suggesting that Tie1 is involved in lymphangiogenesis.

  8. A natural antisense transcript was identified for tyrosine kinase (show TYRO3 Proteins) containing immunoglobulin and epidermal growth factor (show EGF Proteins) homology domain-1 (tie-1), tie-1AS long noncoding RNA in zebrafish, mouse, and humans.

  9. In the lung, Tie1 expression increases prior to birth and rises in the newborn animal, a pattern not found in other organs.

  10. Blood vessel homeostasis and endothelial cell survival depend on proper signalling through angiopoietin receptors such as the receptor tyrosine kinases Tie-1 and Tie-2 (show TEK Proteins). Tie-1 and Tie-2 (show TEK Proteins) localized to motile cilia of the oviduct.

TIE1 Protein Profile

Protein Summary

This gene encodes a member of the tyrosine protein kinase family. The encoded protein plays a critical role in angiogenesis and blood vessel stability by inhibiting angiopoietin 1 signaling through the endothelial receptor tyrosine kinase Tie2. Ectodomain cleavage of the encoded protein relieves inhibition of Tie2 and is mediated by multiple factors including vascular endothelial growth factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with TIE1

  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (TIE1)
  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (LOC100350418)
  • tyrosine-protein kinase receptor Tie-1 (CpipJ_CPIJ018933)
  • endothelium-specific receptor tyrosine kinase 1 (tie1)
  • tyrosine kinase with immunoglobulin-like and EGF-like domains 1 (Tie1)
  • D430008P04Rik protein
  • JTK14 protein
  • TIE protein
  • tie-1 protein

Protein level used designations for TIE1

tyrosine-protein kinase receptor Tie-1 , tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1 , tyrosine kinase with immunoglobulin and epidermal growth factor homology domains , tyrosine kinase receptor 1

GENE ID SPECIES
482535 Canis lupus familiaris
100350418 Oryctolagus cuniculus
6053379 Culex quinquefasciatus
30746 Danio rerio
7075 Homo sapiens
280941 Bos taurus
21846 Mus musculus
89806 Rattus norvegicus
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