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anti-Human TSC1 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended TSC1 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 1 (TSC1) Antibodies
  • tsc1
  • wu:fc38b04
  • LAM
  • TSC
  • hamartin
  • mKIAA0243
  • tuberous sclerosis 1
  • tuberous sclerosis 1b
  • TSC1
  • tsc1b
  • tsc1
  • Tsc1
Epitope
C-Term, Isoform 1
48
40
40
40
40
30
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
16
12
12
10
7
7
7
7
5
5
4
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Reactivity
Human
449
378
172
28
7
6
5
1
1
Host
Goat
739
47
18
2
Clonality
Polyclonal
Conjugate
This TSC1 antibody is un-conjugated
67
67
67
64
64
64
4
4
4
4
4
3
3
3
3
3
3
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
532
517
158
65
39
33
28
16
14
8
4
2
1
Supplier
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Catalog No. ABIN251283
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.701424 ABIN214014 IHC (p) WB Rabbit C-Term Log in to see Polyclonal
11.701424 ABIN256973 IHC (p) IHC WB Rabbit Log in to see Polyclonal
1 ABIN652207 IF IHC (p) WB Rabbit Ig AA 401-430, Center Log in to see Polyclonal 2
1 ABIN303311 IF IHC (p) WB Rabbit Middle Region Log in to see Polyclonal
1 ABIN1491685 IHC (p) WB Mouse IgG2a AA 836-1164 Log in to see 3A2
1 ABIN1491686 IHC (p) WB Mouse IgG2b AA 836-1164 Log in to see 5A8
1 ABIN3044051 IHC (p) WB Rabbit IgG AA 1150-1164, C-Term Log in to see Polyclonal
1 ABIN574381 IHC (p) ELISA WB Goat AA 1150-1163 Log in to see Polyclonal
1 ABIN302894 IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN214539 ICC IHC (p) WB Rabbit Middle Region Log in to see Polyclonal
1 ABIN961783 IHC (p) IP ELISA WB Mouse IgG1 Log in to see
1 ABIN1740408 IHC (p) ELISA WB Goat C-Term Log in to see Polyclonal
1 ABIN2476985 IHC (fro) IHC (p) WB Rabbit IgG Center Log in to see Polyclonal 2
1 ABIN711971 IF (p) IHC (p) WB Rabbit IgG pSer505 Log in to see Polyclonal
1 ABIN1740410 ICC IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN1740409 IHC (p) WB Rabbit IgG Log in to see Polyclonal
1 ABIN2621707 IHC (p) WB Rabbit IgG AA 1150-1164 Log in to see Polyclonal
1 ABIN704855 IHC (p) HRP Rabbit IgG Log in to see Polyclonal
1 ABIN711980 IHC (p) WB HRP Rabbit IgG pSer505 Log in to see Polyclonal
1 ABIN1711351 IHC (p) WB HRP Rabbit IgG Log in to see Polyclonal

Top referenced anti-TSC1 antibody for Immunohistochemistry (Paraffin-embedded Sections)

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General

Antigen Tuberous Sclerosis 1 (TSC1) Antibodies
Epitope C-Term, Isoform 1
(48), (40), (40), (40), (40), (30), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (16), (12), (12), (10), (7), (7), (7), (7), (5), (5), (4), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(449), (378), (172), (28), (7), (6), (5), (1), (1)
Host Goat
(739), (47), (18), (2)
Clonality
Polyclonal
Conjugate This TSC1 antibody is un-conjugated
(67), (67), (67), (64), (64), (64), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (1), (1)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
(532), (517), (158), (65), (39), (33), (28), (16), (14), (8), (4), (2), (1)
Pubmed 2 references available
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Product Details anti-TSC1 Antibody

Target Details TSC1 Application Details Handling References for anti-TSC1 Antibody (ABIN251283) Images
Specificity This antibody is expected to recognise isoform 1 (NP_000359.1) only.
Purification Immunogen affinity purified
Immunogen Peptide with sequence C-QLHIMDYNETHHEH corresponding to C-Terminus according to NP_000359.1.

Target Details TSC1

Product Details anti-TSC1 Antibody Application Details Handling References for anti-TSC1 Antibody (ABIN251283) Images back to top
Antigen
Alternative Name TSC1 (TSC1 Antibody Abstract)
Background Gene Symbol: TSC1
Gene ID 7248
NCBI Accession NP_000359
Pathways RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation

Application Details

Product Details anti-TSC1 Antibody Target Details TSC1 Handling References for anti-TSC1 Antibody (ABIN251283) Images back to top
Application Notes Western Blot 0.1 - 0.3 μg/mL, Immunohistochemistry 3 - 6 μg/mL, Immunohistochemistry-Paraffin 3 - 6 μg/mL, Peptide ELISA Detection limit 1:128000WB: Approx. 150 kDa band observed in human brain lysates is reported in scientific literature (PMID: 10915759). In transfected HEK293 transiently expressing human TSC1 a band of approx. 120 kDa is observed. This band is not observed in the non-transfected HEK293. IHC-P: Human uterus shows membranous staining around non-basal nuclei and at the lumen of the endometrial gland.
Comment

The antibodies are intended for use in vitro experiments only. Our antibodies have not been tested nor are recommended for use in vivo.

Restrictions For Research Use only

Handling

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details References for anti-TSC1 Antibody (ABIN251283) Images back to top
Format Liquid
Concentration 0.5 mg/mL
Buffer 0.5 mg/mL Tris ( pH 7.3) and 0.5 % BSA
Buffer contains: 0.02 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid freeze-thaw cycles
Storage -20 °C
Storage Comment Store at -20°C. Avoid freeze-thaw cycles.

References for anti-TSC1 Antibody (ABIN251283)

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling Images back to top
Product cited in:

Chan, Zhang, Roberts, Jozwiak, Wieslawa, Lewin-Kowalik, Kotulska, Kwiatkowski: "Pathogenesis of tuberous sclerosis subependymal giant cell astrocytomas: biallelic inactivation of TSC1 or TSC2 leads to mTOR activation." in: Journal of neuropathology and experimental neurology, Vol. 63, Issue 12, pp. 1236-42, 2004

Miloloza, Rosner, Nellist, Halley, Bernaschek, Hengstschläger: "The TSC1 gene product, hamartin, negatively regulates cell proliferation." in: Human molecular genetics, Vol. 9, Issue 12, pp. 1721-7, 2000

Images

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling References for anti-TSC1 Antibody (ABIN251283) back to top
Supplier Images
Western Blotting (WB) image for anti-TSC1 antibody (Tuberous Sclerosis 1) (C-Term) (ABIN251283) ABIN251283 (0.1?g/ml) staining of Human Brain lysate (35?g protein in RIPA buffer). ...
Western Blotting (WB) image for anti-TSC1 antibody (Tuberous Sclerosis 1) (C-Term) (ABIN251283) Western Blot: TSC1 Antibody [ABIN251283] - HEK293 overexpressing Human TSC1 and probe...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-TSC1 antibody (Tuberous Sclerosis 1) (C-Term) (ABIN251283) Immunohistochemistry-Paraffin: TSC1 Antibody [ABIN251283] - staining.