anti-Rat (Rattus) TSC1 antibody for Dot Blot

Recommended TSC1 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 1 (TSC1) Antibodies
  • tsc1
  • wu:fc38b04
  • LAM
  • TSC
  • hamartin
  • mKIAA0243
  • tuberous sclerosis 1
  • tuberous sclerosis 1b
  • TSC1
  • tsc1b
  • tsc1
  • Tsc1
Epitope
pThr417
50
43
40
40
40
40
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
19
16
12
12
10
9
7
7
7
7
5
5
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Reactivity
Rat (Rattus)
464
380
172
28
7
6
5
1
1
Host
Rabbit
743
57
19
2
Clonality
Polyclonal
Conjugate
This TSC1 antibody is un-conjugated
67
67
67
64
64
64
5
5
5
5
5
3
3
3
3
3
3
2
2
Application
Dot Blot (DB)
531
519
167
66
39
34
29
21
17
8
4
2
2
1
Options
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Catalog No. ABIN1881908
$ 324.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
28.580097 ABIN1881909 DB Rabbit pTyr297 Log in to see Polyclonal 5
28.580097 ABIN1881906 DB Rabbit pSer1141 Log in to see Polyclonal 5
28.580097 ABIN1881907 DB Rabbit pSer312 Log in to see Polyclonal 5
28.580097 ABIN3029284 DB ELISA Rabbit Ig Fraction pSer1141 Log in to see Polyclonal
28.580097 ABIN3029286 DB ELISA Rabbit Ig Fraction pSer312 Log in to see Polyclonal
28.580097 ABIN3029302 DB ELISA Rabbit Ig Fraction pThr417 Log in to see Polyclonal
28.580097 ABIN3029304 DB ELISA Rabbit Ig Fraction pTyr297 Log in to see Polyclonal
1 ABIN2605255 DB ELISA Rabbit IgG pSer1141 Log in to see Polyclonal
1 ABIN2605256 DB ELISA Rabbit IgG pSer312 Log in to see Polyclonal
1 ABIN2605272 DB ELISA Rabbit IgG pThr417 Log in to see Polyclonal
1 ABIN2605273 DB ELISA Rabbit IgG pTyr297 Log in to see Polyclonal
1 ABIN1968099 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pSer1141 Log in to see Polyclonal
1 ABIN1968103 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pSer312 Log in to see Polyclonal
1 ABIN1968108 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pThr417 Log in to see Polyclonal
1 ABIN1968121 DB ELISA APC Rabbit IgG pSer1141 Log in to see Polyclonal
1 ABIN1968109 DB ELISA Alkaline Phosphatase (AP) Rabbit IgG pTyr297 Log in to see Polyclonal
1 ABIN1968125 DB ELISA APC Rabbit IgG pSer312 Log in to see Polyclonal
1 ABIN1968130 DB ELISA APC Rabbit IgG pThr417 Log in to see Polyclonal
1 ABIN1968131 DB ELISA APC Rabbit IgG pTyr297 Log in to see Polyclonal
1 ABIN1968215 DB ELISA Biotin Rabbit IgG pSer1141 Log in to see Polyclonal

General

Antigen Tuberous Sclerosis 1 (TSC1) Antibodies
Epitope pThr417
(50), (43), (40), (40), (40), (40), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (19), (16), (12), (12), (10), (9), (7), (7), (7), (7), (5), (5), (4), (4), (3), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Rat (Rattus)
(464), (380), (172), (28), (7), (6), (5), (1), (1)
Host Rabbit
(743), (57), (19), (2)
Clonality (Clone)
Polyclonal   ( )
Conjugate This TSC1 antibody is un-conjugated
(67), (67), (67), (64), (64), (64), (5), (5), (5), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2)
Application Dot Blot (DB)
(531), (519), (167), (66), (39), (34), (29), (21), (17), (8), (4), (2), (2), (1)
Pubmed 5 references available
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Product Details anti-TSC1 Antibody

Target Details TSC1 Application Details Handling References for anti-TSC1 antibody (ABIN1881908) Images
Purification This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Immunogen This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T417 of rat TSC1.
Clone RB41269

Target Details TSC1

Product Details anti-TSC1 Antibody Application Details Handling References for anti-TSC1 antibody (ABIN1881908) Images back to top
Antigen
Alternative Name TSC1 (TSC1 Antibody Abstract)
Background In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).

Synonyms: Tsc1, Hamartin, Tuberous sclerosis 1 protein homolog
NCBI Accession NP_068626
UniProt Q9Z136
Pathways RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation

Application Details

Product Details anti-TSC1 Antibody Target Details TSC1 Handling References for anti-TSC1 antibody (ABIN1881908) Images back to top
Application Notes DB: 1:500
Restrictions For Research Use only

Handling

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details References for anti-TSC1 antibody (ABIN1881908) Images back to top
Format Liquid
Concentration 0.43 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

References for anti-TSC1 antibody (ABIN1881908)

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling Images back to top
Product cited in:

Inoue, Ndong, Suzuki, Kazami, Uyama, Kobayashi, Tadokoro, Yamamoto: "Hamartin-Hsp70 interaction is necessary for Akt-dependent tuberin phosphorylation during heat shock." in: Bioscience, biotechnology, and biochemistry, Vol. 73, Issue 11, pp. 2488-93, 2009

Di Nardo, Kramvis, Cho, Sadowski, Meikle, Kwiatkowski, Sahin: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, 2009

Chen, Yan, Chen, He: "The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats." in: Experimental and molecular pathology, Vol. 86, Issue 2, pp. 101-7, 2009

Momose, Kobayashi, Tada, Itoyama, Hino: "N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo." in: Biochemical and biophysical research communications, Vol. 356, Issue 3, pp. 693-8, 2007

Background publications

Goncharova, Goncharov, Noonan, Krymskaya: "TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase." in: The Journal of cell biology, Vol. 167, Issue 6, pp. 1171-82, 2004

Images

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Supplier Images
Dot Blot (DB) image for anti-Tuberous Sclerosis 1 (TSC1) (pThr417) antibody (ABIN1881908) Dot blot analysis of rat TSC1 Antibody (Phospho T417) Phospho-specific Pab (ABIN18819...