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|Application / Reactivity||Rat (Rattus)|
|Dot Blot (DB)||76 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Immunocytochemistry (ICC)||7 Antibodies|
|Immunofluorescence (IF)||6 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||33 Antibodies|
|Immunohistochemistry (IHC)||6 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||15 Antibodies|
|Western Blotting (WB)||40 Antibodies|
|Antigen||Tuberous Sclerosis 1 (TSC1) Antibodies|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This TSC1 antibody is un-conjugated Alternatives|
Dot Blot (DB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-TSC1 AntibodyTarget Details TSC1 Application Details Handling References for anti-TSC1 Antibody (ABIN1881906) Images
|Purification||This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)|
|Immunogen||This rat TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S1141 of rat TSC1.|
Target Details TSC1Product Details anti-TSC1 Antibody Application Details Handling References for anti-TSC1 Antibody (ABIN1881906) Images back to top
|Alternative Name||TSC1 (TSC1 Antibody Abstract)|
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).
Synonyms: Tsc1, Hamartin, Tuberous sclerosis 1 protein homolog
|Pathways||RTK Signaling, AMPK Signaling|
Application DetailsProduct Details anti-TSC1 Antibody Target Details TSC1 Handling References for anti-TSC1 Antibody (ABIN1881906) Images back to top
|Application Notes||DB: 1:500|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TSC1 Antibody Target Details TSC1 Application Details References for anti-TSC1 Antibody (ABIN1881906) Images back to top
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.|
|Precaution of Use||WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.|
References for anti-TSC1 Antibody (ABIN1881906)Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling Images back to top
|Product cited in:||
Inoue, Ndong, Suzuki et al.: "Hamartin-Hsp70 interaction is necessary for Akt-dependent tuberin phosphorylation during heat shock." in: Bioscience, biotechnology, and biochemistry, Vol. 73, Issue 11, pp. 2488-93, 2009 (PubMed).
Di Nardo, Kramvis, Cho et al.: "Tuberous sclerosis complex activity is required to control neuronal stress responses in an mTOR-dependent manner." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 18, pp. 5926-37, 2009 (PubMed).
Chen, Yan, Chen et al.: "The variation of AkT/TSC1-TSC1/mTOR signal pathway in hepatocytes after partial hepatectomy in rats." in: Experimental and molecular pathology, Vol. 86, Issue 2, pp. 101-7, 2009 (PubMed).
Momose, Kobayashi, Tada et al.: "N-terminal hamartin-binding and C-terminal GAP domain of tuberin can separate in vivo." in: Biochemical and biophysical research communications, Vol. 356, Issue 3, pp. 693-8, 2007 (PubMed).
Goncharova, Goncharov, Noonan et al.: "TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase." in: The Journal of cell biology, Vol. 167, Issue 6, pp. 1171-82, 2004 (PubMed).
ImagesProduct Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling References for anti-TSC1 Antibody (ABIN1881906) back to top