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anti-Rat (Rattus) TSC1 antibody for Immunocytochemistry

Recommended TSC1 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 1 (TSC1) Antibodies
  • hamartin
  • LAM
  • mKIAA0243
  • TSC
  • tsc1
  • wu:fc38b04
Epitope
Middle Region, both Isoforms
51
40
40
40
40
27
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
20
17
15
12
12
12
12
8
7
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
6
4
4
3
3
3
3
3
2
2
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
424
358
152
5
1
1
1
1
1
1
Host
Rabbit
727
37
18
1
Clonality
Polyclonal
Conjugate
This TSC1 antibody is un-conjugated
67
67
67
64
64
64
3
3
3
3
3
3
3
3
3
Application
Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
532
488
152
62
33
32
18
13
7
5
4
2
1
Supplier
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Catalog No. ABIN2500749
$ 535.71
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0010161072 ABIN1740410 ICC IHC (p) WB Rabbit IgG Log in to see Polyclonal
0.0010161072 ABIN1031146 ICC ELISA WB Rabbit Middle Region Log in to see Polyclonal
0.0010161072 ABIN1886907 ICC ELISA WB Rabbit both Isoforms, Middle Region Log in to see Polyclonal
0.0010161072 ABIN1585466 ICC ELISA WB Rabbit Log in to see Polyclonal
0.0010161072 ABIN2959980 ICC IF ELISA WB Rabbit IgG Middle Region, both Isoforms Log in to see Polyclonal
0.0010161072 ABIN2983945 ICC IF IHC WB Rabbit IgG Log in to see Polyclonal

Similar anti-TSC1 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
Dot Blot (DB) 76 Antibodies 247 Antibodies
ELISA 69 Antibodies 203 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 2 Antibodies
Immunocytochemistry (ICC) 7 Antibodies 7 Antibodies
Immunofluorescence (IF) 6 Antibodies 6 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 33 Antibodies 33 Antibodies
Immunohistochemistry (IHC) 6 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 15 Antibodies
Western Blotting (WB) 40 Antibodies
Flow Cytometry (FACS) 1 Antibodies

General

Antigen Tuberous Sclerosis 1 (TSC1) Antibodies
Epitope Middle Region, both Isoforms
(51), (40), (40), (40), (40), (27), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (17), (15), (12), (12), (12), (12), (8), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (4), (4), (3), (3), (3), (3), (3), (2), (2), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(424), (358), (152), (5), (1), (1), (1), (1), (1), (1)
Host Rabbit
(727), (37), (18), (1)
Clonality
Polyclonal
Conjugate This TSC1 antibody is un-conjugated
(67), (67), (67), (64), (64), (64), (3), (3), (3), (3), (3), (3), (3), (3), (3)
Application Immunocytochemistry (ICC), ELISA, Western Blotting (WB)
(532), (488), (152), (62), (33), (32), (18), (13), (7), (5), (4), (2), (1)
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Product Details anti-TSC1 Antibody

Target Details TSC1 Application Details Handling Images
Predicted Reactivity Human Mouse Rat
Characteristics Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high. Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro, suggesting that the TSC1/TSC2 decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth. A shorter 40 kDa isoform of TSC1 has been shown to exist but its function is unknown.
Purification Affinity chromatography purified via peptide column
Immunogen The immunogen for anti-TSC1 antibody: antibody was raised against a 15 amino acid peptide from the middle region of human TSC1. TSC1 antibody will recognize both isoforms of TSC1.

Target Details TSC1

Product Details anti-TSC1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name TSC1 (TSC1 Antibody Abstract)
Gene ID 7248
Pathways RTK Signaling, AMPK Signaling

Application Details

Product Details anti-TSC1 Antibody Target Details TSC1 Handling Images back to top
Application Notes TSC1 antibody can be used for the detection of TSC1 by Western blot at 1 μg/mL
Restrictions For Research Use only

Handling

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Images back to top
Handling Advice As with all antibodies care should be taken to avoid repeated freeze thaw cycles.
Antibodies should not be exposed to prolonged high temperatures.
Storage 4 °C
Storage Comment TSC1 antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Expiry Date 12 months

Images

Product Details anti-TSC1 Antibody Target Details TSC1 Application Details Handling back to top
Supplier Images
Immunofluorescence (IF) image for anti-TSC1 antibody (Tuberous Sclerosis 1) (Middle Region) (ABIN2500749) anti-Tuberous Sclerosis 1 (TSC1) (Middle Region), (both Isoforms) antibody
Western Blotting (WB) image for anti-TSC1 antibody (Tuberous Sclerosis 1) (Middle Region) (ABIN2500749) anti-Tuberous Sclerosis 1 (TSC1) (Middle Region), (both Isoforms) antibody (Image 2)
Immunocytochemistry (ICC) image for anti-TSC1 antibody (Tuberous Sclerosis 1) (Middle Region) (ABIN2500749) anti-Tuberous Sclerosis 1 (TSC1) (Middle Region), (both Isoforms) antibody (Image 3)