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|Application / Reactivity||Human||Rat (Rattus)|
|Western Blotting (WB)||150 Antibodies||49 Antibodies|
|Immunoprecipitation (IP)||8 Antibodies||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||34 Antibodies||19 Antibodies|
|Immunohistochemistry (IHC)||66 Antibodies||6 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||39 Antibodies||39 Antibodies|
|Immunofluorescence (IF)||28 Antibodies||9 Antibodies|
|Immunocytochemistry (ICC)||16 Antibodies||9 Antibodies|
|Immunochromatography (IC)||2 Antibodies|
|Antigen||Tuberous Sclerosis 1 (TSC1) Antibodies|
|Epitope||AA 686-884 Alternatives|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This TSC1 antibody is un-conjugated Alternatives|
Western Blotting (WB)
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Product Details anti-TSC1 AntibodyTarget Details TSC1 Application Details Handling Images
|Purpose||Rabbit IgG polyclonal antibody for Hamartin(TSC1) detection. Tested with WB in Human,Rat.|
|Cross-Reactivity (Details)||No cross reactivity with other proteins.|
Rabbit IgG polyclonal antibody for Hamartin(TSC1) detection. Tested with WB in Human,Rat.
Gene Name: tuberous sclerosis 1
Protein Name: Hamartin
|Purification||Immunogen affinity purified.|
|Immunogen||E.coli-derived human Hamartin recombinant protein (Position: D686-Y884). Human Hamartin shares 96% and 95% amino acid (aa) sequences identity with mouse and rat Hamartin, respectively.|
Target Details TSC1Product Details anti-TSC1 Antibody Application Details Handling Images back to top
|Alternative Name||TSC1 (TSC1 Antibody Abstract)|
Hamartin also known as tuberous sclerosis 1 is a protein that in humans is encoded by the TSC1 gene. It is mapped to 9q34.13. This peripheral membrane protein was implicated as a tumor suppressor. It forms a complex with TSC2 that regulates mTORC1 signaling and may be also involved in vesicular transport and docking. Hamartin and TSC2 have critical roles in neuronal polarity, and that a common pathway regulates polarization and growth in neurons and cell size in other tissues. Hamartin is a growth inhibitory protein whose biologic effect is probably dependent on its interaction with tuberin. It also can affect cell proliferation via deregulation of G1 phase. Loss or perturbation of Hamartin function leads to loss of adhesion to the cellular matrix and initiates the development of TSC hamartomas.
Synonyms: Hamartin antibody|kiaa0243 antibody|LAM antibody|TSC antibody|TSC1 antibody|Tsc1 gene antibody|TSC1_HUMAN antibody|Tuberous sclerosis 1 antibody|Tuberous sclerosis 1 protein antibody
|Pathways||RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation|
Application DetailsProduct Details anti-TSC1 Antibody Target Details TSC1 Handling Images back to top
WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for Hamartin is approximately 0.25 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results.
Other applications have not been tested. Optimal dilutions should be determined by end users.
Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
|Restrictions||For Research Use only|
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|Reconstitution||Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.|
|Buffer||Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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