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studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis
Results implicate a contributory role of WAVE1 (show WASF1 Proteins) and -3 to the metastatic phenotype of PC-3 (show PCSK1 Proteins) cells through their interaction with the ARP2 (show ACTR2 Proteins)/3 complex.
stabilization of WASF3 function occurs through its interaction with ATAD3A (show ATAD3A Proteins) and GRP78 (show HSPA5 Proteins), which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
We show that WAVE3-mediated modulation of NFkappaB (show NFKB1 Proteins) is required for invadopodia formation as well as MMP9 (show MMP9 Proteins) expression and activity that are needed for cancer cells to degrade the ECM (show MMRN1 Proteins)
WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells.
WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail (show SNAI1 Proteins).
miR (show MLXIP Proteins)-217 functions as a tumor-suppressive miRNA and inhibits the osteosarcoma tumorigenesis through targeting WASF3.
Upregulated WAVE3 expression is essential for TGF-beta (show TGFB1 Proteins)-mediated EMT (show ITK Proteins) and metastasis of triple-negative breast cancer cells.
ZEB1/2 upregulation by WASF3 results from downregulation of KISS1 (show KISS1 Proteins), leading to the release of inhibition of nuclear factor (NF)kappaB (show NFKB1 Proteins) by IkappaBalpha (show NFKBIA Proteins)
these results define a novel signaling network whereby JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) signaling creates a feed-forward loop to raise activated WASF3 levels that promote cancer cell motility.
WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
wiskott-Aldrich syndrome protein family member 3
, WASP family Verprolin-homologous protein 3
, WASP family protein member 3
, protein WAVE-3
, verprolin homology domain-containing protein 3