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p63alpha protein up-regulates heat shock protein 70 (show HSP70 Proteins) expression via E2F1 transcription factor (show E2F1 Proteins) 1 (show HNF1A Proteins), promoting Wasf3/Wave3/MMP9 (show MMP9 Proteins) signaling and bladder cancer invasion
we show that WASF3 is present in the HER2 (show ERBB2 Proteins) immunocomplex and suppression of WASF3 function leads to suppression of invasion even in the presence of HER2 (show ERBB2 Proteins) expression.The engagement of WASF3 with the HER2 (show ERBB2 Proteins)/HER3 (show ERBB3 Proteins) complex facilitates its phospho-activation and transcriptional upregulation, which is facilitated by HER2 (show ERBB2 Proteins)/HER3 (show ERBB3 Proteins) activation of JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling.
we show that stapled peptides targeting the interface between NCKAP1 (show NCKAP1 Proteins) and CYFIP1 (show CYFIP1 Proteins) destabilize the WASF3 complex... thereby suppressing invasion and metastasis of breast cancer cells.
It was concluded that WAVE3 may represent a new adverse prognostic factor for patients with ICC.
studies provide a deeper understanding of the critical role for WASF3 in facilitating increased invasion potential in cancer cells expressing mutant RAS and supports the idea that targeting WASF3 in metastatic cells overexpressing RAS may be used to suppress invasion and metastasis
Results implicate a contributory role of WAVE1 (show WASF1 Proteins) and -3 to the metastatic phenotype of PC-3 (show PCSK1 Proteins) cells through their interaction with the ARP2 (show ACTR2 Proteins)/3 complex.
stabilization of WASF3 function occurs through its interaction with ATAD3A (show ATAD3A Proteins) and GRP78 (show HSPA5 Proteins), which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles
We show that WAVE3-mediated modulation of NFkappaB (show NFKB1 Proteins) is required for invadopodia formation as well as MMP9 (show MMP9 Proteins) expression and activity that are needed for cancer cells to degrade the ECM (show MMRN1 Proteins)
WAVE3 is pivotal in controlling oncogenic phenotypes of human hepatocellular carcinoma cells.
WAVE3 promotes epithelial-mesenchymal transition of gastric cancer through upregulation of Snail (show SNAI1 Proteins).
WAVE3 transcript is mainly expressed in the nervous system and, like all the members of the WASP gene family, WAVE3 is a key element in actin polymerization and cytoskeleton organization.
This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function.
wiskott-Aldrich syndrome protein family member 3
, WASP family Verprolin-homologous protein 3
, WASP family protein member 3
, protein WAVE-3
, verprolin homology domain-containing protein 3