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the Src (show SRC Proteins) tyrosine kinase (show TXK Proteins) Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) is associated with suberoylanilide hydroxamic acid resistance.
we provide evidence for involvement of HCK (show HCK Proteins) and FGR in FCRL4 (show FCRL4 Proteins)-mediated immunoregulation and for the functional importance of posttranslational modifications of the FCRL4 (show FCRL4 Proteins) molecule.
Data indicate that combined treatment using SFK (LYN (show LYN Proteins), HCK (show HCK Proteins), or FGR) and c-KIT inhibitor dasatinib dasatinib and chemotherapy provides a novel approach to increasing p53 (show TP53 Proteins) activity and enhancing targeting of acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) stem cells.
Fgr plays a biologically significant role in ovarian cancer growth and might represent an important target
Recruitment of the coactivator, SRC2 (show NCOA2 Proteins), is coupled to cooperative DNA binding by the progesterone receptor (show PGR Proteins).
the Hck, Fgr and Lyn kinases are also necessary for amastigote uptake by macrophages. Src-mediated Arg activation is required for efficient uptake.
Data indicate that Src (show SRC Proteins)-Family Kinases Hck (show HCK Proteins) and Fgr regulate cytokine secretion by macrophages.
Fgr is not only are progressively overexpressed in atherosclerosis, but it also controls critical molecular processes in monocyte influx, blood monocyte subset balance, macrophage accumulation, and the maintenance of atherosclerotic lesion stability.
Ablation of Fgr abolishes the capacity of mitochondria to adjust metabolism upon nutrient restriction, hypoxia/reoxygenation, and T cell activation, demonstrating the physiological relevance of this adaptive response.
The Src (show SRC Proteins) family kinases Hck (show HCK Proteins), Fgr, and Lyn (show LYN Proteins) are critical for the generation of the in vivo inflammatory environment without a direct role in leukocyte recruitment.
The Src family kinase Fgr is critical for activation of mast cells and IgE-mediated anaphylaxis in mice.
Despite possessing enhanced killing, alveolar macrophage Fgr/Hck (show HCK Proteins)/Lyn (show LYN Proteins)-deficient ("triple-knockout") mice do not demonstrate enhanced inflammatory responses to Pneumocystis murina.
Hck and Fgr function as negative regulators of myeloid cell chemokine signaling by maintaining the tonic phosphorylation of PIR-
interaction of MIST (show CLNK Proteins) with Fgr, mediated by the C-terminal proline-rich region of MIST (show CLNK Proteins) and the SH3 domain of Fgr, was required for the suppression of NK-cell receptor (show KLRD1 Proteins)-induced IFN-gamma (show IFNG Proteins) production
Fgr plays no role in chemoattractant-induced, inside-out beta 2 integrin activation of neutrophils but regulates their outside-in, signaling-dependent sustained adhesion.
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.
, basic fibroblast growth factor receptor 1
, fibroblast growth factor receptor 1
, proto-oncogene c-Fgr
, tyrosine-protein kinase Fgr
, proto-oncogene tyrosine-protein kinase FGR
, Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
, tyrosine-protein kinase Fgr-like
, Gardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog
, proto-oncogene tyrosine-protein kinase Fgr
, c-fgr protooncogene
, c-src-2 proto-oncogene
, p55-c-fgr protein
, v-fgr feline Gardner-Rasheed sarcoma viral oncogene homolog