Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
Select your origin of interest
CDC42 (show CDC42 Proteins) is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
MAPK (show MAPK1 Proteins) cascades participate in osteogenesis, but only the ERK (show EPHB2 Proteins) signaling pathway responds to FGFR1 (show FGFR1 Proteins).
It is well accepted that myelin is a biologically active membrane in active communication with the axons. However, the axonal signals, the receptors on myelin, and the integration of intracellular signaling pathways emanating downstream from these receptors that drive the growth of the myelin sheath remain poorly understood in the CNS. This study brings up the intriguing possibility that FGF receptor (show FGFR2 Proteins) 2, in the oligodendr
data suggest that FGF2 (show FGF2 Proteins) levels are critically related to anxiety behavior and hypothalamic pituitary- adrenal axis activity, likely through modulation of hippocampal glucocorticoid receptor (show NR3C1 Proteins) expression, an effect that is likely receptor mediated, albeit not by FGFR1 (show FGFR1 Proteins), FGFR2 (show FGFR2 Proteins), and FGFR3 (show FGFR3 Proteins).
increased activity of the PI3K/AKT (show AKT1 Proteins) signaling pathway in Pelo (show PELO Proteins)-deficient skin might conflict with the dephosphorylation of profilaggrin and thereby affect its proper processing into filaggrin monomers and ultimately the epidermal differentiation
clearly demonstrate the different specificity of FGF12 (show FGF12 Proteins)-FGFR1c2 and FGF22 (show FGF22 Proteins)-FGFR1c2 for well defined HS structures and suggest that it is now possible to chemoenzymatically synthesize precise HS polysaccharides that can selectively mediate growth factor signaling
The study supports a pro-adipogenic role for betaKlotho (show KLB Proteins) in skeletal muscle fibro/adipogenesis and calls for further research on involvement of the FGF-FGFR (show FGFR2 Proteins)-betaKlotho (show KLB Proteins) axis in the fibro/adipogenic infiltration associated with functional deterioration of skeletal muscle in aging and muscular dystrophy.
These new findings reveal that the FGF21-betaKlotho-FGFR1 signaling axis plays roles in maintaining phospholipid homeostasis and the dynamic functions of the lipid droplet, whereas protecting against ER stress, and suggest a potential link of phospholipid biosynthesis, lipid droplet dynamics, ER stress, and energy homeostasis in adipose tissue coordinated by this signaling axis.
Data suggest that Fgf1 (show FGF1 Proteins)-mediated signaling represents an important signaling cascade related to adipogenesis and visceral adiposity; expression of Fgf1 (fibroblast growth factor 1 (show FGF1 Proteins)) and Fgfr1 (fibroblast growth factor receptor 1 (show FGFR1 Proteins)) is up-regulated in adipose tissue of obese mice (both obese mice due to high-fat diet and obese mice due to genetic deletion of leptin (show LEP Proteins)).
FGFR1OP2 (show FGFR1OP2 Proteins)-FGFR1 (show FGFR1 Proteins) fusion in hematopoietic stem cells induced myeloid leukemia (show BCL11A Proteins) and T-cell lymphoma in a mouse model.
FLG (show FGFR1 Proteins) mutations are risk factors for atopic dermatitis in Finns, but disease severity and treatment response were independent of patient FLG (show FGFR1 Proteins) status.
Patients with both atopic dermatitis and common filaggrin gene mutations are more frequently affected by reduced health-related quality of life
Multiple lines of evidence suggest that FLG (show FGFR1 Proteins) genetic variation, have little or no effect on fitness in modern humans. Haplotype-level analysis revealed a recent selective sweep which increased the allele frequency of the Huxian haplogroup in Asian populations.
FLG (show FGFR1 Proteins) mutations lead to alterations in epidermal eicosanoid metabolism in atopic dermatitis patients
Filaggrin gene mutations are risk factors for the presence and persistence of atopic dermatitis and explain the discordance of atopic dermatitis within dizygotic twin pairs.
Variations in FLG (show FGFR1 Proteins) and TSLP (show TSLP Proteins) genotype were associated with differences in self-reported skin clearance, TCI (show LXN Proteins) usage, and steroid usage.
We show that subjects with FLG (show FGFR1 Proteins)-null mutations have more mature Langerhans cells in nonlesional skin irrespective of whether they have AD.
we have proposed that this latitude-dependent gradient of FLG (show FGFR1 Proteins) mutations across Europe, Asia and Africa could have provided an evolutionary advantage for heterozygous FLG (show FGFR1 Proteins) mutation carriers, residing at northern latitudes, depletion of the FLG (show FGFR1 Proteins) downstream product, trans-urocanic acid, would facilitate the intracutaneous synthesis of vitamin D3 by allowing increased transcutaneous absorption of UVB photons
The results of the present study demonstrate that filaggrin knockdown inhibits NHEK migration, adhesion and proliferation, promotes apoptosis and disturbs cell cycle progression.
FLG (show FGFR1 Proteins) rs2065955 polymorphism was significantly related to gastric carcinoma.
The protein encoded by this gene is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Mutations in this gene are associated with ichthyosis vulgaris.
, basic fibroblast growth factor receptor 1
, proto-oncogene c-Fgr
, epidermal filaggrin
, Filaggrin (profilaggrin)
, keratin intermediate filament-associated protein