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Human SIX1 Protein expressed in Escherichia coli (E. coli) - ABIN1098684
Oliver, Wehr, Jenkins, Copeland, Cheyette, Hartenstein, Zipursky, Gruss: Homeobox genes and connective tissue patterning. in Development (Cambridge, England) 1995
Show all 2 references for ABIN1098684
Human SIX1 Protein expressed in Wheat germ - ABIN1320061
Yu, Davicioni, Triche, Merlino: The homeoprotein six1 transcriptionally activates multiple protumorigenic genes but requires ezrin to promote metastasis. in Cancer research 2006
Studies strongly suggest that Six1 overexpression promotes CRC growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM (show CCNA1 Proteins). MAPK (show MAPK1 Proteins) activation may be a pivotal event in Six1-associated tumor progression.
Downregulation of Six1 effectively inhibited airway inflammation and reversed airway remodeling, which suggest that Six1 represents a promising therapeutic strategy for human allergic asthma.
results suggest that SIX1 is a key proliferation regulator in mouse DFCs and human PDLCs, which provides novel insight into Six family gene function in mammals.
Our findings imply that SIX1 may play a role as an important regulator to orchestrate the dynamic of uterine endometrium in response to estrogen level during the estrous cycle.
Activation of Six1 Expression in Vertebrate Sensory Neurons.
Six1 knockdown caused a fast-to-slow shift in myosin heavy chain isoform
Results suggest that the increase of SIX1 expression could promote tumorigenesis, progression and invasive growth of cervical cancer by promoting DNA replication.
Fast myosin heavy chain (show MYH8 Proteins) (MYH (show MUTYH Proteins)) genes and linc-MYH (show MUTYH Proteins) share a common enhancer, located in the fast MYH (show MUTYH Proteins) gene locus and regulated by Six1 homeoproteins
The results indicated the critical role of Six1 in transition of Rohon-Beard cells to dorsal root ganglia (DRG) neurons during Xenopus development and establishment of exclusive DRG system of mice.
Six1 is required for the proper chromatin structure at the Core Enhancer Region, as well as for MyoD (show MYOD1 Proteins) binding at its own enhancer.
Studies strongly suggest that Six1 overexpression promotes CRC (show CALR Proteins) growth and metastasis and remodels tumor stroma by stimulating angiogenesis and recruiting TAM (show CCNA1 Proteins). MAPK (show MAPK1 Proteins) activation may be a pivotal event in Six1-associated tumor progression.
Restoration of SIX1 was sufficient to abolish proliferation, migration and invasion induced by miR (show MLXIP Proteins)-362 overexpression in cervical cancer cells. The newly identified miR (show MLXIP Proteins)-362/SIX1 pathway provides insight into cervical cancer progression, and may represent a novel therapeutic target.
study replicated the association of POAG with two SNPs at the SIX1-SIX6 (show SIX6 Proteins) locus and demonstrated that SNPs, rs10483727 and rs33912345, are significantly associated with POAG, especially with NTG (show OPA1 Proteins) in patients aged above 40 years
miR (show MLXIP Proteins)-188 suppresses proliferation and invasion by targeting SIX1 in oral squamous cell carcinoma cells.
Pro-survival effects by NF-kappaB (show NFKB1 Proteins), Akt (show AKT1 Proteins) and ERK(1 (show MAPK3 Proteins)/2) and anti-apoptosis actions by Six1 disrupt apoptotic functions of TRAIL-Dr4 (show HLADRB4 Proteins)/5 pathway in ovarian cancer, which may explain why up-regulated DR4 (show HLADRB4 Proteins) and DR5 (show TNFRSF10B Proteins) in ovarian cancer are associated with poor prognosis and low survival ratio of the patients.
Upregulation of Six1 could downregulate miR (show MLXIP Proteins)-204-5p expression.
Mutations of SIX1 gene underlie Wilms tumor recurrences.
Six1 signaling has a role in paclitaxel-dependent apoptosis in MCF-7 cell line
Six1 mutations/gene deletion are unlikely to be a major cause of nonsyndromic CAKUT.
The HD domain is important for the nuclear localization of porcine Six1 protein.
Microarray identification of novel genes downstream of Six1, a critical factor in cranial placode, somite, and kidney development.
Eya1 (show EYA1 Proteins) and Six1 are required for both the regulation of placodal neuronal progenitor proliferation, through their effects on SoxB1 expression, and subsequent neuronal differentiation.
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3).
homeobox protein SIX1
, sine oculis homeobox homolog 1
, sine oculis-related homeobox 1 homolog
, Sine oculis homeobox homolog 1
, homeobox protein six1