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Eaat1 expression is promoted by Fringe-mediated neuron-glial communication during development and suggest that Eaat1 plays an essential role in regulating central nervous system neural circuits that control locomotion in Drosophila
dEAAT1 is present at the adult, but surprisingly not at embryonic and larval NMJ, suggesting a physiological maturation of the junction during metamorphosis
crystal structures of a thermostabilized human SLC1 (show MCHR1 Proteins) transporter, the excitatory amino acid transporter 1 (EAAT1), with and without allosteric and competitive inhibitors bound
This study demonstrated that the cytopathology and episodic paralysis in our Drosophila EA6 model stem from a gain-of-function chloride channelopathy of glial cells..
Starvation of Muller cells increased the glutamate (show GRIN1 Proteins) uptake capacity as well as the expression of the most abundant glutamate transporter (show SLC1A1 Proteins), EAAT1.
A heterozygous SLC1A3 c.1177G4A mutation has been detected in a patient with late-onset episodic ataxia. Same heterozygous mutation was identified in one clinically affected family member and two asymptomatic members.
that Abeta1-42 oligomers could cause disturbances in insulin (show INS Proteins)/Akt (show AKT1 Proteins)/EAAT (show SLC1A2 Proteins) signaling in astrocytes
We consider an association between SLC1A3 and the behavioural problems which can also be considered a contributing factor to behavioural problems in larger duplications overlapping the 5p13 microduplication syndrome region.
In combination with other nearby residues, Arg-388 coordinates anion channel gating and forms part of the missing structural link between the anion conducting and substrate transport states in EAAT1.
SPAK (show STK39 Proteins) and OSR1 (show OXSR1 Proteins) are powerful negative regulators of the excitatory glutamate (show GRIN1 Proteins) transporters EAAT1 and EAAT2 (show SLC1A2 Proteins).
There was no association between pyramidal cell EAAT1 splice variant expression and schizophrenia.
data provide additional insights into the mechanism by which substrates gate the anion conductance in EAATs and suggest that in EAAT1, Arg-388 is a critical element for the structural coupling between the substrate translocation and the gating mechanisms
SLC1A3 maintains a constant import of acidic amino acids independently of nutritional status in adipocytes.
glutamate/aspartate transporter (GLAST) was elevated in 8- to 10- and/or 20- to 22-month GHR (show GHR Proteins)-KO mice when comparing genotypes
This study findings demonstrate that Ascl1 (show ASCL1 Proteins)(CreERT2) and Glast(CreERT2) mouse lines enable simple and reliable labeling of adult-born GC lineages within restricted time windows.
arundic acid treatment prevented RGC death by upregulating GLAST in heterozygous (GLAST(+/-)) mice
Results show that expression of GLAST is decreased in cerebellar astrocytes in a mouse model of SCA1; decrease occurs in non-cell autonomous manner late in disease and correlates well with the loss of Purkinje neurons
we have demonstrated for the first time that DOR receptor activation induces astrocytic expression of EAAT1 and EAAT2 (show SLC1A2 Proteins)
The result showed significant correlation between changes in GLUT 8 (show SLC2A8 Proteins) and glucose levels with changes in StAR level in the testis and circulating testosterone level in the mice from birth to senescence
EAAT1 activity and sodium potassium-ATPase activity are co-regulated by a tightly coupled homeostatic relationship in astrocytes.
Study suggests that there is a remarkable subcellular heterogeneity of GLAST and GLT-1 expression in the developing hippocampus
TNR (show TNR Proteins) is expressed in a subset of astrocytes and contributes to glutamate (show GRIN1 Proteins) homeostasis by regulating astrocytic GLAST expression.
This gene encodes a member of a member of a high affinity glutamate transporter family. Mutations in this gene are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.
, drosophila glutamate transporter-1
, excitatory amino acid transporter 1
, glutamate transporter
, sodium-dependent excitatory amino acid transporter 1
, sodium-dependent glutamate transporter
, excitatory amino acid transporter SLC1A3a
, solute carrier family 1 (glial high affinity glutamate transporter), member 3
, Na+-dependent glutamate/aspartate transporter
, Sodium-dependent glutamate/aspartate transporter 1
, excitatory amino acid transporter 1-like
, glial glutamate transporter
, glutamate/aspartate transporter
, sodium-dependent glutamate/aspartate transporter 1
, solute carrier family 1, member 3
, solute carrier family 1 member 3
, glial high affinity glutamate transporter
, high-affinity neuronal glutamate transporter