Browse our EPAS1 Proteins (EPAS1)

Full name:
Endothelial PAS Domain Protein 1 Proteins (EPAS1)
On are 10 Endothelial PAS Domain Protein 1 (EPAS1) Proteins from 4 different suppliers available. Additionally we are shipping EPAS1 Antibodies (219) and EPAS1 Kits (20) and many more products for this protein. A total of 256 EPAS1 products are currently listed.
bhlhe73, ecyt4, EPAS, EPAS-1, EPAS1, HIF-2alpha, hif2, hif2a, hif2alpha, hlf, HRF, mop2, pasd2
list all proteins Gene Name GeneID UniProt
EPAS1 2034 Q99814
EPAS1 13819 P97481
EPAS1 29452 Q9JHS1

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EPAS1 Proteins (EPAS1) by Origin

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Top referenced EPAS1 Proteins

  1. Human EPAS1 Protein expressed in Wheat germ - ABIN1352871 : Coltella, Percio, Valsecchi, Cuttano, Guarnerio, Ponzoni, Pandolfi, Melillo, Pattini, Bernardi: HIF factors cooperate with PML-RAR? to promote acute promyelocytic leukemia progression and relapse. in EMBO molecular medicine 2014 (PubMed)

More Proteins for EPAS1 Interaction Partners

Human Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. HIF1A (show HIF1A Proteins) and HIF2A contribute to cancer stem cells survival but play different roles -HIF1A (show HIF1A Proteins) being more responsible for survival functions and HIF2A for self-renewal [review].

  2. The negative feedback modulation between LncRNA-SARCC/AR complex and HIF-2alpha signaling may then lead to differentially modulated RCC (show XRCC1 Proteins) progression in a VHL (show VHL Proteins)-dependent manner. Together, these results may provide us a new therapeutic approach via targeting this newly identified signal from LncRNA-SARCC to AR-mediated HIF-2alpha/C-MYC (show MYC Proteins) signals against RCC (show XRCC1 Proteins) progression.

  3. Results suggested that the oncogenic transcription factor HIF-2alpha stabilized VHL (show VHL Proteins) disease suppressor B-Myb (show MYBL2 Proteins), which is also a transcription factor, by physical interaction. Some B-Myb (show MYBL2 Proteins)-dependent gene expression was similarly affected by B-Myb (show MYBL2 Proteins) or HIF-2alpha knockdown, suggesting that stabilization of B-Myb (show MYBL2 Proteins) by HIF-2alpha may play a role in specific gene expressions.

  4. Data suggest a common mechanism by which DNA methyltransferase1 (DNMT1 (show DNMT1 Proteins)) and hypoxia inducible factors HIF1alpha (show HIF1A Proteins)/HIF2alpha regulate Sprouty2 (Spry2 (show SPRY2 Proteins)) transcription.

  5. Hypoxia microenvironment in hepatocellular carcinoma up-regulates HIF2/SCF (show KITLG Proteins) expression, which in turn promotes angiogenesis and HCC (show FAM126A Proteins) metastasis.

  6. CK1delta enhances EPO (show EPO Proteins) secretion from liver cancer cells under hypoxia by modifying HIF-2alpha and promoting its nuclear accumulation.

  7. LOX (show LOX Proteins), a hypoxia-responsive gene that encodes lysyl oxidase (show LOX Proteins), is activated by HIF-2-alpha more than HIF-1 (show HIF1A Proteins). Two new hypoxia response elements identified in the LOX (show LOX Proteins) promoter mediate most HIF responsiveness.

  8. Our results indicate that HPV16 E6/E7 indirectly upregulated the expression of VEGF by inhibition of liver kinase B1 expression and upregulation of hypoxia-inducible factor 2alpha expression,thus propose a human papillomavirus-liver kinase B1-hypoxia-inducible factor 2A-vascular endothelial growth factor axis for the tumorigenesis of lung cancer

  9. HIF-2a rs13419896 polymorphism is associated with an increased risk of chronic hepatitis B and liver cirrhosis (LC) in the Guangxi Chinese population, especially in females and in the non-alcohol-drinking population, while the HIF-2a gene rs6715787 polymorphism is associated with a decreased risk of LC in the Guangxi Zhuang population

  10. we identified a total of 204 variants across the entire gene region of EPAS1 (97.0 kb) in Tibetans. Tibetan-Specific EPAS1 Haplotype Down-Regulates Expression. Heterozygous EPAS1 knockout mice display blunted physiological responses to chronic hypoxia. We propose down-regulation of EPAS1 contributes to the molecular basis of Tibetans' adaption to high-altitude hypoxia.

Mouse (Murine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. this study shows that HIF-2alpha acts in resting macrophages as a phagocytosis suppressor implying an important relationship between the levels of HIF-2alpha and susceptibility to infection

  2. in neurons HIF-1 (show HIF1A Proteins) and HIF-2 have redundant functions for cellular survival under ischemic conditions. By contrast, lack of anti-survival factors in Hif1a (show HIF1A Proteins)/Hif2a-deficient mice might protect from early acute neuronal cell death and neurological impairment, indicating a benefit of HIF-pathway inhibition in neurons in the very acute phase after ischemic stroke

  3. HIF-2alpha is a novel regulator of neutrophil recruitment to colon tumors.

  4. AQP1 (show AQP1 Proteins) deficiency delays long-term ischemia-reperfusion resolution, partly through repressing angiogenesis mediated by destabilizing HIF-2alpha.

  5. HIF1alpha (show HIF1A Proteins) and HIF2alpha are dispensable for muscle stem cell function under normoxia but are required for maintaining satellite cell self-renewal in hypoxic environments.

  6. eIF3e (show EIF3E Proteins) is an angiogenesis suppressor. Silencing of eIF3e (show EIF3E Proteins) promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2alpha activity.

  7. The regulatory connection between HIF-2alpha and VEGFR-1 (show FLT1 Proteins), VEGFR-2 (show KDR Proteins) and MMP2 (show MMP2 Proteins).

  8. HIF2alpha is essential for the acute postprandial regulation of hepatic glucagon (show GCG Proteins) signaling.

  9. demonstrate that HIF-2alpha is clearly implicated in the TSP1 (show GZMA Proteins) pulmonary regulation and provide new insights on its contribution to pulmonary arterial hypertension-driven vascular remodelling and vasoconstriction

  10. Findings identify a reciprocal activation mechanism involving HIF-2alpha and the zinc-ZIP8 (show SLC39A8 Proteins)-MTF1 (show MTF1 Proteins) axis during osteoarthritis pathogenesis that amplifies catabolic signaling and cartilage destruction.

Pig (Porcine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. immunostaining for HIF-1alpha (show HIF1A Proteins) and HIF-2alpha was observed during endochondral ossification; only HIF-2alpha was present at sites of intramembranous ossification

Cow (Bovine) Endothelial PAS Domain Protein 1 (EPAS1) interaction partners

  1. There was an association of an EPAS1 (HIF2alpha) double variant in the oxygen degradation domain of EPAS1 in Angus cattle with high altitude pulmonary hypertension (HAPH). There was upregulation of 26 of 27 HIF2alpha target genes in EPAS1 carriers with HAPH.

EPAS1 Protein Profile

Protein Summary

This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.

Alternative names and synonyms associated with EPAS1

  • endothelial PAS domain protein 1 (EPAS1)
  • endothelial PAS domain protein 1 (epas1)
  • endothelial PAS domain protein 1 (Epas1)
  • bhlhe73 protein
  • ecyt4 protein
  • EPAS protein
  • EPAS-1 protein
  • EPAS1 protein
  • HIF-2alpha protein
  • hif2 protein
  • hif2a protein
  • hif2alpha protein
  • hlf protein
  • HRF protein
  • mop2 protein
  • pasd2 protein

Protein level used designations for EPAS1

endothelial PAS domain protein 1 , endothelial PAS domain-containing protein 1-like , EPAS-1 , HIF-1-alpha-like factor , HIF-1alpha-like factor , HIF-2-alpha , HIF2-alpha , PAS domain-containing protein 2 , basic-helix-loop-helix-PAS protein MOP2 , class E basic helix-loop-helix protein 73 , endothelial PAS domain-containing protein 1 , hypoxia-inducible factor 2 alpha , hypoxia-inducible factor 2-alpha , member of PAS protein 2 , HIF-related factor , HIF1 alpha-like factor , HIF1alpha-like factor , HLF (HIF1alpha-like factor) , Hif like protein , hypoxia inducible transcription factor 2alpha , mHLF , HIF-2 alpha , HIF2 alpha , hypoxia inducible factor 2, alpha subunit , hypoxia inducible factor 2a , HIF-2alpha

459204 Pan troglodytes
714641 Macaca mulatta
100220014 Taeniopygia guttata
100396711 Callithrix jacchus
100439667 Pongo abelii
100543912 Meleagris gallopavo
100551891 Anolis carolinensis
100606638 Nomascus leucogenys
2034 Homo sapiens
13819 Mus musculus
29452 Rattus norvegicus
444145 Xenopus laevis
395596 Gallus gallus
474578 Canis lupus familiaris
100037272 Sus scrofa
282711 Bos taurus
100068622 Equus caballus
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