Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all species
Show all synonyms
Select your species
Membrane localization and dynamics of geranylgeranylated Rab5 hypervariable region has been reported.
study elucidated a novel Malat1-miR-101-STMN1/RAB5A/ATG4D regulatory network that Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma cells
In conclusion, mutant KRAS promotes endosomal degradation in PDAC cell lines, which is impaired by KRAS silencing. Moreover, KRAS silencing activates RAB5A upregulation and drives PDAC subtype-dependent modulation of endosome trafficking.
siRNA knockdown of Rab5a or overexpression of miR (show MLXIP ELISA Kits)-494 in human macrophages significantly inhibits the survival of the parasites
our results show that Rab5a is overexpressed in pancreatic cancer and promotes aggressive biological behavior through regulation of the Wnt (show WNT2 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits) signaling pathway.
CMTM3 (show CMTM3 ELISA Kits) decreases EGFR (show EGFR ELISA Kits) expression, facilitates EGFR (show EGFR ELISA Kits) degradation, and inhibits the EGF (show EGF ELISA Kits)-mediated tumorigenicity of gastric cancer cells by enhancing Rab5 activity.
High RAS-associated protein (show RGL2 ELISA Kits) RAB5 expression correlated with the presence of lymphatic invasion and venous invasion and low E-cadherin (show CDH1 ELISA Kits) expression.
downregulated Rab5a led to slowed cell growth, decreased numbers of migrated cells, decreased numbers of cells at the G0G1 phase and a higher apoptosis rate. However, PDGF (show PDGFA ELISA Kits) significantly rescued these phenomena caused by siRNA against Rab5a
results suggest a new mechanism in which Rab5 induces a change in flexibility of EEA1 (show EEA1 ELISA Kits), generating an entropic collapse force that pulls the captured vesicle towards the target membrane to initiate docking and membrane fusion
structural differences may provide an opportunity to selectively target one Rab5 state and lead to new approaches in the development of Rab5-specific therapies
SH3GLB1 (show SH3GLB1 ELISA Kits) controls nicotinic acetylcholine receptors endocytic trafficking in a phosphorylation- and RAB5-dependent manner at steps upstream of autophagosome formation.
E. chaffeensis secretes Etf-1 (show ETF1 ELISA Kits) to induce autophagy to repurpose the host cytoplasm and capture nutrients for its growth through RAB5 and class III PtdIns3K, while avoiding autolysosomal killing.
These data highlight a requirement of Rab5 and the endosomal system for the regulation of gluconeogenic gene expression that has important implications for metabolic diseases.
Inpp5e (show INPP5E ELISA Kits), through functional interactions with Rab20 on the phagosome, activates Rab5, which, in turn, increases PtdIns3P and delays phagosome acidification.
FGF21 (show FGF21 ELISA Kits) has a role in promoting endothelial cell angiogenesis through a dynamin-2 (show DNM2 ELISA Kits) and Rab5 dependent pathway
In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin (show NCDN ELISA Kits) palmitoylation in its targeting to Rab5-positive endosomes.
In mammalian cells, p110beta acts as a molecular sensor for growth factor availability and induces autophagy by activating a Rab5-mediated signaling cascade.
Data show that Rinl is closely associated with the cytoskeleton and thus contributes to the spatial control of Rab5a and Rab22 signaling at actin-positive compartments.
Data reveal the affinity of Rabex-5 (show RABGEF1 ELISA Kits)/Rabaptin-5 (show RABEP1 ELISA Kits)/Rab5-GTP (show AK3 ELISA Kits) interaction in the cell, which is quantitatively related to the Rabex-5 (show RABGEF1 ELISA Kits) concentration for the onset of the indirect
Rab5 regulates and coordinates different endocytic mechanisms through its effector Rabankyrin-5 (show ANKFY1 ELISA Kits)
Expression of dominant negative Rab5 and Rab7 (show RAB7A ELISA Kits) mutants, but not the dominant negative Rab11 (show RAB11A ELISA Kits) mutant, significantly inhibited classical swine fever virus replication. These results were confirmed by silencing of Rab5 and Rab7 (show RAB7A ELISA Kits).
Dominant-negative mutant rab5 inhibits FMDV infection of IBRS-2 cells.
Required for the fusion of plasma membranes and early endosomes (By similarity).
, Rab5a, GTPase
, hypothetical protein
, Ras-related protein Rab-5A
, ras-related protein rab-5a
, RAB5A, member RAS oncogene family
, ras-related protein Rab-5A
, RAS-associated protein RAB5A
, small GTP-binding protein rab5
, GTP-binding protein (rab5)