Browse our DIS3L2 Proteins (DIS3L2)

Full name:
DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2 Proteins (DIS3L2)
On www.antibodies-online.com are 4 DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2 (DIS3L2) Proteins from 3 different suppliers available. Additionally we are shipping DIS3L2 Antibodies (32) and many more products for this protein. A total of 37 DIS3L2 products are currently listed.
Synonyms:
4930429A22Rik, 8030493P09Rik, DIS3L2, DKFZp469O0522, FAM6A, hDIS3L2, PRLMNS, RGD1560168
list all proteins Gene Name GeneID UniProt
Rat DIS3L2 DIS3L2 367307  
DIS3L2 129563 Q8IYB7
DIS3L2 208718 Q8CI75

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DIS3L2 Proteins (DIS3L2) by Origin

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More Proteins for DIS3L2 Interaction Partners

Human DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2 (DIS3L2) interaction partners

  1. Our findings establish the role of DIS3L2 and oligouridylation as the cytoplasmic quality control for highly structured ncRNAs

  2. Studies indicate important roles of the exoribonucleases DIS3L2 and XRN1 (show XRN1 Proteins) in cellular function, viability and disease.

  3. these results indicate that catalytically inactive DIS3L2, characteristic of Perlman syndrome, can lead to deregulation of its target RNAs to disturb transcriptome homeostasis.

  4. DIS3L2 interacts with Ago2 (show EIF2C2 Proteins) and governs target RNA-directed miRNA degradation.

  5. DIS3L2 is the missing component of the LIN28 (show LIN28A Proteins)-TUT4 (show ZCCHC11 Proteins)/7-DIS3L2 pathway required for the repression of let-7 in pluripotent cells.

  6. in cellular models DIS3L2 knockdown is associated with abnormalities of cell growth and division

  7. Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility.

Mouse (Murine) DIS3 Mitotic Control Homolog (S. Cerevisiae)-Like 2 (DIS3L2) interaction partners

  1. DIS3L2 interacts with Ago2 (show EIF2C2 Proteins) and governs target RNA-directed miRNA degradation.

  2. structure of mouse Dis3l2 in complex with an oligoU RNA to mimic the uridylated tail of pre-let-7

  3. identification of Dis3l2 as the 3'-5' exonuclease (show EXOSC10 Proteins) responsible for the decay of uridylated pre-let-7 in mouse embryonic stem cells

DIS3L2 Protein Profile

Protein Summary

The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene.

Alternative names and synonyms associated with DIS3L2

  • DIS3 mitotic control homolog (S. cerevisiae)-like 2 (Dis3l2)
  • DIS3 mitotic control homolog (S. cerevisiae)-like 2 (DIS3L2)
  • 4930429A22Rik protein
  • 8030493P09Rik protein
  • DIS3L2 protein
  • DKFZp469O0522 protein
  • FAM6A protein
  • hDIS3L2 protein
  • PRLMNS protein
  • RGD1560168 protein

Protein level used designations for DIS3L2

DIS3 mitotic control homolog-like 2 , DIS3-like exonuclease 2 , DIS3 mitotic control-like 2 , DIS3 mitotic control homolog (S. cerevisiae)-like 2 , DIS3-like exonuclease 2-like , family with sequence similarity 6, member A

GENE ID SPECIES
367307 Rattus norvegicus
519222 Bos taurus
610194 Canis lupus familiaris
100153005 Sus scrofa
424934 Gallus gallus
712905 Macaca mulatta
100064500 Equus caballus
100171476 Pongo abelii
100344728 Oryctolagus cuniculus
100398360 Callithrix jacchus
100465652 Ailuropoda melanoleuca
100540548 Meleagris gallopavo
100605598 Nomascus leucogenys
129563 Homo sapiens
208718 Mus musculus
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