Browse our GATA2 Proteins (GATA2)

Full name:
GATA Binding Protein 2 Proteins (GATA2)
On www.antibodies-online.com are 11 GATA Binding Protein 2 (GATA2) Proteins from 5 different suppliers available. Additionally we are shipping GATA2 Antibodies (124) and GATA2 Kits (22) and many more products for this protein. A total of 162 GATA2 products are currently listed.
Synonyms:
DCML, Gata-2, Gata2, MONOMAC, NF-E1b, NFE1B, xgata-2, xgata2
list all proteins Gene Name GeneID UniProt
GATA2 2624 P23769
GATA2 14461 O09100
GATA2 25159 Q924Y4

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GATA2 Proteins (GATA2) by Origin

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Human GATA Binding Protein 2 (GATA2) interaction partners

  1. GATA2 deficiency is associated with impaired membrane expression and chemotactic dysfunctions of CXCR4 (show CXCR4 Proteins).

  2. decline of GATA2 resulting from mutations contributes to the erythroid commitment, differentiation and the development of AEL

  3. the distinct mechanisms by which GATA2 and FOXA1 (show FOXA1 Proteins) regulate AR cistrome and suggest that FOXA1 (show FOXA1 Proteins) acts upstream of GATA2 and AR in determining hormone-dependent gene expression in prostate cancer.

  4. adaptive NK cells can persist in patients with GATA2 mutation, even after NK-cell progenitors expire.

  5. reducing GATA2 expression or inhibition of its transcription activity can relieve the drug resistance of acute myeloid leukemia (show BCL11A Proteins) cells and it would be helpful for eliminating the leukemia cells in patients

  6. we suggest screening for GATA2 mutations in pediatric myelodysplastic syndrome, preferentially in patients with impaired B-cell homeostasis in bone marrow and peripheral blood (low number of progenitors, intronRSS-Kde recombination excision circles and naive cells.

  7. Knockdown of GATA-2 caused NGB (show GTPBP4 Proteins) expression to drop dramatically, indicating GATA-2 as an essential transcription factor for the activation of NGB (show GTPBP4 Proteins) expression via binding to a novel distal regulatory element of NGB (show GTPBP4 Proteins).

  8. we demonstrated that miR (show MLXIP Proteins)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1 (show MECOM Proteins)) mRNA is a direct target of miR (show MLXIP Proteins)-22 and MECOM (EVI1 (show MECOM Proteins)) functions as a negative regulator in the differentiation.The miR (show MLXIP Proteins)-22-mediated MECOM (show MECOM Proteins) degradation increased c-Jun (show JUN Proteins) but decreased GATA2 expression, which results in increased interaction between c-Jun (show JUN Proteins) and PU.1

  9. analysis of two separate cases of pediatric AML/MDS with underlying GATA2 mutations who underwent a successful umbilical cord hematopoietic stem cell transplantation using two different conditioning regimens [case report/review]

  10. germ line mutations in GATA2 are associated with GATA2 deficiency syndrome, whereas acquired mutations are seen in myelodysplastic syndrome, acute myeloid leukemia (show BCL11A Proteins), and in blast crisis transformation of chronic myeloid leukemia (show BCL11A Proteins).

Xenopus laevis GATA Binding Protein 2 (GATA2) interaction partners

  1. bcar3 gene is expressed downstream of Gata2 during gastrulation, and is co-expressed with gata2 but is more broadly expressed during later development; its binding partner, bcar1 (show BCAR1 Proteins) shows overlapping expression patterns

  2. results are consistent with a model in which GATA2 contributes to inhibition of canonical Wnt (show WNT2 Proteins) signaling

  3. these findings, strongly implicate Dlx3 in the regulation of non-neural competence, and show that GATA2 contributes to non-neural competence but is not sufficient to promote it ectopically.

  4. Studies suggest a two-component model for the binding of CBTF with gata2 promoter, requiring both a CCAAT and A-form DNA, and the double stranded RNA binding domains (dsRBDs) of CBTF component Xilf3 must be active for both binding to the promoter.

  5. Gata-2 is a transcriptional target downstream of BMPs within ectodermal cells, while activation of the CaM KIV signaling pathway alters GATA-2 function posttranslationally, by inhibiting its acetylation.

Cow (Bovine) GATA Binding Protein 2 (GATA2) interaction partners

  1. GATA2 and/or GATA3 (show GATA3 Proteins) are involved in the regulation of trophoblast-specific gene transcription in bovine trophoblast CT-1 (show SLC6A8 Proteins) cells

Mouse (Murine) GATA Binding Protein 2 (GATA2) interaction partners

  1. Gata2 heterozygous deletion confers selective advantage to EVI1 (show MECOM Proteins)-expressing leukemia cell expansion in recipient mice

  2. impairment of trophoblast-specific GATA2/GATA3 (show GATA3 Proteins) function could lead to early pregnancy failure

  3. both Gata2 and Gata3 (show GATA3 Proteins) are redundantly required for differentiation of the serotonergic and glutamatergic neurons of the dorsal raphe

  4. Dynamically and epigenetically coordinated GATA2/ETS1SOX7 transcription factor expression is indispensable for endothelial cell differentiation.

  5. High GATA2 expression is associated with leukemia.

  6. results suggest that GATA2 plays an important role in cell-fate specification toward the myeloid vs T-lymphocyte lineage by regulating lineage-specific transcription factors in DC progenitors, thereby contributing to DC differentiation.

  7. These results demonstrated that an enforced expression of Gata2 in late HECs of differentiated ESCs (show NR2E3 Proteins) efficiently promotes megakaryopoiesis followed by platelet production. This study provides valuable information for ex vivo platelet production from human pluripotent stem cells in future.

  8. we identified important roles for the GATA-2 C-ZnF in bone marrow hematopoiesis via control of c-Kit expression and HSC/HSPC survival.

  9. Data show that transforming growth factor beta (TGFbeta (show TGFB1 Proteins))-induced changes in Gata2 transcription factor and cyclin-dependent kinase inhibitor 1C (P57 (show CDKN1C Proteins)) expression in hematopoietic progenitors are conveyed through Smad (show SMAD1 Proteins) signaling via Smad4 protein (show SMAD4 Proteins).

  10. Gata2 as a crucial rheostat of mesenchymal stem cell fate to control osteoblast and adipocyte lineage development.

GATA2 Protein Profile

Protein Summary

This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with GATA2

  • GATA binding protein 2 (GATA2)
  • GATA binding protein 2 (LOC100222005)
  • amidase (gatA2)
  • glutamyl/aspartyl-tRNA(Gln/Asp) amidotransferasesubunit A (gatA2)
  • hypothetical protein (gatA2)
  • glutamyl-tRNA(Gln) amidotransferase, subunit GatA (Glu-ADT subunit A) (gatA2)
  • GATA2 transcription factor (Gata2)
  • endothelial transcription factor GATA-2 (Smp_018590)
  • GATA binding protein 2 (gata2)
  • GATA binding protein 2 (Gata2)
  • uterine GATA-4 transcription factor (LOC100008832)
  • DCML protein
  • Gata-2 protein
  • Gata2 protein
  • MONOMAC protein
  • NF-E1b protein
  • NFE1B protein
  • xgata-2 protein
  • xgata2 protein

Protein level used designations for GATA Binding Protein 2 Proteins (GATA2)

GATA binding protein 2 , amidase , glutamyl/aspartyl-tRNA(Gln/Asp) amidotransferasesubunit A , hypothetical protein , protein GatA2 , GATA2 transcription factor , endothelial transcription factor GATA-2-like , endothelial transcription factor GATA-2 , GATA binding factor-2 , GATA-2 , GATA-binding factor 2 , transcription factor xGATA-2 , transcription factor NF-E1B , transcription factor GATA-2 , GATA-binding protein 2 , GATA-bindning protein 2

GENE ID SPECIES
100049949 Equus caballus
100222005 Taeniopygia guttata
460672 Pan troglodytes
705551 Macaca mulatta
3130812 Haloarcula marismortui ATCC 43049
4456439 Ralstonia eutropha H16
5804717 Sorangium cellulosum So ce56
7502616 Desulfobacterium autotrophicum HRM2
9454391 Bacillus cereus biovar anthracis str. CI
100313614 Saccoglossus kowalevskii
100411598 Callithrix jacchus
100479406 Ailuropoda melanoleuca
100605529 Nomascus leucogenys
8344167 Schistosoma mansoni
2624 Homo sapiens
399273 Xenopus laevis
416018 Gallus gallus
484626 Canis lupus familiaris
396912 Sus scrofa
506809 Bos taurus
14461 Mus musculus
25159 Rattus norvegicus
100723770 Cavia porcellus
100820748 Ovis aries
100008832 Oryctolagus cuniculus
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