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Browse our SMC1A Proteins (SMC1A)

Full name:
Structural Maintenance of Chromosomes 1A Proteins (SMC1A)
On www.antibodies-online.com are 4 Structural Maintenance of Chromosomes 1A (SMC1A) Proteins from 3 different suppliers available. Additionally we are shipping SMC1A Antibodies (236) and SMC1A Kits (7) and many more products for this protein. A total of 250 SMC1A products are currently listed.
Synonyms:
5830426I24Rik, CDLS2, DXS423E, im:7158706, mKIAA0178, NV15570, Sb1.8, SMC-1A, smc1, smc1a, smc1aa, Smc1alpha, Smc1l1, SMC1L2, Smcb, xSMC1, zgc:76902
list all proteins Gene Name GeneID UniProt
SMC1A 8243 Q14683
SMC1A 24061 Q9CU62
Rat SMC1A SMC1A 63996 Q9Z1M9

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SMC1A Proteins (SMC1A) by Origin

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More Proteins for SMC1A Interaction Partners

Zebrafish Structural Maintenance of Chromosomes 1A (SMC1A) interaction partners

  1. zebrafish embryos and SMC1A-mutated pa (show NIPBL Proteins)tient-derived fibroblasts were used to analyze abnormalities induced by SMC1A loss of function

Human Structural Maintenance of Chromosomes 1A (SMC1A) interaction partners

  1. High SMC1A expression is associated with prostate cancer.

  2. Results showed that the high expression of SMC1 often promoted epithelial-mesenchymal transition, accompanied by the enhanced expression of Brachyury (show TBX1 Proteins) in triple-negative breast cancer cells.

  3. SMC1A plays an oncogenic role in colorectal cancer.

  4. Loss-of-function mutations of SMC1A may be associated with early-onset encephalopathy with epilepsy.

  5. numerous dysregulated genes occupied by cohesin by combining the transcriptome of CdLS (show NIPBL Proteins) cell lines carrying mutations in SMC1A gene, were identified.

  6. two novel de novo heterozygous frameshift mutations in the SMC1A gene were identified in two patients with developmental delay and epilepsy.

  7. Our findings identify both SMC1 and CTCF (show CTCF Proteins) as critical regulators of the differentiation-dependent life cycle of high-risk human papillomaviruses

  8. same down-regulation of cohesin target (show NIPBL Proteins)s is observed in SMC1A-mutated patient fibroblasts

  9. Results show that SMC1A is overexpressed in colorectal cancer tissues and correlated with poor prognosis for late stage disease.

  10. The SMC1a mutation leads to chromosomal instability and tumorigenesis in early colorectal adenomas.

Mouse (Murine) Structural Maintenance of Chromosomes 1A (SMC1A) interaction partners

  1. To decipher the functions of the two meiosis-specific kleisins, REC8 (show REC8 Proteins) or RAD21L (show RAD21L1 Proteins), together with the only meiosis-specific SMC protein SMC1b (show SMC1B Proteins), we generated Smc1b (show SMC1B Proteins)-/-Rec8 (show REC8 Proteins)-/- and Smc1b (show SMC1B Proteins)-/-Rad21L (show RAD21L1 Proteins)-/- mouse mutants.

  2. expression analysis of Smc1a and Nipbl (show NIPBL Proteins) in developing mouse embryos reveals a specific pattern in the hindbrain

  3. SMC1A participates in tissue-specific enhancer-promoter interactions and interactions that demarcate regions of correlated regulatory output.

  4. Point mutation at the Nbs1 (show NBN Proteins) Threonine 278 site does not affect mouse development, but compromises the Chk2 (show CHEK2 Proteins) and Smc1 phosphorylation after DNA damage.

  5. A positively charged channel within the Smc1/Smc3 (show SMC3 Proteins) hinge required for sister chromatid cohesion.

  6. SMC1alpha is mainly associated with homologous or non-homologous synapsed regions. The protein also localizes along meiotic chromosome cores of Spo11 (show SPO11 Proteins) null spermatocytes.

  7. observations suggest that many of the abnormal stress responses seen in cells lacking ATM (show ATM Proteins), NBS1 (show NBN Proteins), or BRCA1 (show BRCA1 Proteins) result from a failure of ATM (show ATM Proteins) migration to sites of DNA breaks and a resultant lack of SMC1 phosphorylation.

  8. SMC1beta (show SMC1B Proteins) was found along the axial elements of synaptonemal complexes in prophase I of testis sections and chromosome spreads . Thus, SMC1beta (show SMC1B Proteins) and not SMC1alpha is likely involved in maintaining cohesion between sister centromeres until anaphase II.

Cow (Bovine) Structural Maintenance of Chromosomes 1A (SMC1A) interaction partners

SMC1A Protein Profile

Protein Summary

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.

Alternative names and synonyms associated with SMC1A

  • structural maintenance of chromosomes 1A, like (smc1al)
  • structural maintenance of chromosomes 1A (SMC1A)
  • structural maintenance of chromosomes 1B (SMC1B)
  • SMC1 structural maintenance of chromosomes 1-like 2 (LOC100337867)
  • structural maintenance of chromosomes 1A (Smc1a)
  • structural maintenance of chromosomes 1A (smc1a)
  • structural maintenance of chromosomes 1A b (smc1ab)
  • 5830426I24Rik protein
  • CDLS2 protein
  • DXS423E protein
  • im:7158706 protein
  • mKIAA0178 protein
  • NV15570 protein
  • Sb1.8 protein
  • SMC-1A protein
  • smc1 protein
  • smc1a protein
  • smc1aa protein
  • Smc1alpha protein
  • Smc1l1 protein
  • SMC1L2 protein
  • Smcb protein
  • xSMC1 protein
  • zgc:76902 protein

Protein level used designations for SMC1A

SMC1 structural maintenance of chromosomes 1-like 1 , SMC1 structural maintenance of chromosomes 1-like 2 , structural maintenance of chromosomes 1A , structural maintenance of chromosomes protein 1A-like , SMC protein 1A , SMC-1-alpha , SMC1 (structural maintenance of chromosomes 1, yeast)-like 1 , segregation of mitotic chromosomes 1 , structural maintenance of chromosomes protein 1A , SMC (segregation of mitotic chromosomes 1)-like 1 , chromosome segregation protein SmcB , segregation of mitotic chromosomes b , SMC-like 1 , structural maintenance of chromosomes 1A a , SMC1 protein cohesin subunit , structural maintenance of chromosomes 1 , SMC-protein , DXhXs423e , segregation of mitotic chromosomes-like 1 , structural maintenance of chromosomes 1 like 1 , 14S cohesin SMC1 subunit

GENE ID SPECIES
403060 Danio rerio
677711 Macaca mulatta
418243 Gallus gallus
458907 Pan troglodytes
100337867 Oryctolagus cuniculus
473619 Pan troglodytes
100120122 Nasonia vitripennis
100402111 Callithrix jacchus
100458659 Pongo abelii
8243 Homo sapiens
24061 Mus musculus
559665 Danio rerio
380182 Xenopus laevis
395187 Gallus gallus
480928 Canis lupus familiaris
282370 Bos taurus
63996 Rattus norvegicus
100379087 Xenopus laevis
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