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The analysis points to a critical role for Hoxa9 (show HOXA9 Proteins) and PU.1 in distal regulation of c-myb (show MYB Proteins) expression in murine myeloid cells during iL-6 (show IL6 Proteins)-induced cell differentiation.
These studies reveal an important role for PU.1 in the regulation of Igkappa transcription and rearrangement and a requirement for PU.1 and Spi-B (show SPIB Proteins) in B cell development.
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in a model of beta-thalassemia
Moreover, the expression of a cell proliferation marker Ki67 (show MKI67 Proteins) was significantly decreased in tumors from the mice not taking doxycycline, compared with that of tumors from the mice continuously taking doxycycline. The present data strongly suggest that PU.1 functions as a tumor suppressor of myeloma cells in vivo.
the affinities of two sequence-divergent ETS (show ETS1 Proteins) homologs, PU.1 and Ets-1 (show ETS1 Proteins), to DNA sites harboring a hemi- and fully methylated CpG dinucleotide, were measured.
this study shows that PU.1 functions as a positive regulator of CD11c (show ITGAX Proteins) gene expression by directly binding to the Itgax (show ITGAX Proteins) promoter and through transactivation of the Irf4 (show IRF4 Proteins) gene
Here we demonstrate that the transcription factors SPI1 (PU.1) and HOXC13 synergistically regulate Zfp521 expression, and identify the regions of the Zfp521 promoter required for this transcriptional activity. We also show that SPI1 and HOXC13 activate Zfp521 in a dose-dependent manner.
findings suggest that Gata1 (show GATA1 Proteins) & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
involved in osteoclast development by transactivating NFATc1 (show NFATC1 Proteins) expression via direct binding to the NFATc1 (show NFATC1 Proteins) promoter
GATA1 (show GATA1 Proteins) and PU.1 bind in vitro and in vivo the proximal promoter region of the RPS19 (show RPS19 Proteins) gene which is frequently mutated in Diamond-Blackfan Anemia.
PU.1-induced apoptosis in myeloma cells is associated with IRF4 (show IRF4 Proteins) downregulation and subsequent IRF7 (show IRF7 Proteins) upregulation.
Most cases of histiocytic sarcoma expressed histiocytic markers CD68 (show CD68 Proteins) (6 of 7 cases), CD163 (show CD163 Proteins) (5 of 5 cases), and PU.1 (3 of 4 cases).
findings highlight a unique role of SPI1 fusions in high-risk pediatric T cell acute lymphoblastic leukemia
expression of an essential mediator of neutrophil terminal differentiation, the ets transcription factor PU.1, was significantly decreased in Hbb(th3/+) neutrophils in beta-thalassemia
RUNX1 (show RUNX1 Proteins) overexpression induced partial DNA demethylation at SPI1 proximal promoter.
This study demonstrated the novel role of PU.1 in the immune response to A. fumigatus through upregulation of Dectin-1 expression and its translocation to the nucleus in A. fumigatus-stimulated THP-1 cells.
PU.1 is an important modulator of VDR (show CYP27B1 PLURAL_@34202@) signaling in monocytes.
Forced FOG1 (show ZFPM1 Proteins) protein expression in K562 erythroleukemia cells induced the expression of SLC4A1 (show SLC4A1 Proteins) protein, but repressed that of transcription factor PU.1.
we demonstrated that miR (show MLXIP Proteins)-22 promoted monocyte/macrophage differentiation, and MECOM (EVI1 (show MECOM Proteins)) mRNA is a direct target of miR (show MLXIP Proteins)-22 and MECOM (EVI1 (show MECOM Proteins)) functions as a negative regulator in the differentiation.The miR (show MLXIP Proteins)-22-mediated MECOM (show MECOM Proteins) degradation increased c-Jun (show JUN Proteins) but decreased GATA2 (show GATA2 Proteins) expression, which results in increased interaction between c-Jun (show JUN Proteins) and PU.1
The vertical and paralleled Pu.1/Spi-b (show SPIB Proteins) regulatory networks control the development of rostral blood island and ventral wall of dorsal aorta-borne macrophages by regulating Irf8 (show IRF8 Proteins).
eaf1 (show EAF1 Proteins) has a role in suppressing foxo3b expression to modulate transcriptional activity of gata1 (show GATA1 Proteins) and spi1 in primitive hematopoiesis
Our results indicate that Kzp (show ANPEP Proteins) is a critical transcriptional factor for the expression of gata2 and pu.1 to modulate primitive hematopoiesis.
Runx1 (show RUNX1 Proteins) is induced by high Pu.1 level and in turn transrepresses pu.1 expression, thus constituting a negative feedback loop that fashions a favorable Pu.1 level required for balanced fate commitment to neutrophils versus macrophages.
The authors show that tif1gamma (show TRIM33 Proteins) modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 (show GATA1 Proteins) and pu.1.
found a gene group downregulated on spi1 knockdown,containing all 5 previously identified Spi1-dependent genes as well as a large set of novel immune-related genes
In zebrafish, spi1 marks a rostral population of LPM cells committed to a myeloid fate anatomically separated from and developmentally independent of erythroid commitment in the caudal LPM.
This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene.
, contrapsin-like protease inhibitor 3
, contrapsin-like protease inhibitor-related protein
, liver regeneration protein lrryan
, serine protease inhibitor 1
, serine protease inhibitor 2.1
, serine protease inhibitor 2a
, serine protease inhibitor A3L
, serpin A3L
, 31 kDa transforming protein
, 31 kDa-transforming protein
, SPI-1 proto-oncogene
, hematopoietic transcription factor PU.1
, spleen focus forming virus (SFFV) proviral integration oncogene spi1
, transcription factor PU.1
, SFFV proviral integration 1 protein
, SFFV proviral integration 1
, spleen focus forming virus proviral integration oncogene spi1
, Spi-1/PU.1 transcription factor
, transcription factor spi1