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Human Polyclonal UGT2B28 Primary Antibody for WB - ABIN1881976
Ménard, Eap, Harvey, Guillemette, Lévesque: Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B17 and UGT2B28 and their associations with a UGT2B15 functional polymorphism. in Human mutation 2009
Show all 4 Pubmed References
Findings suggest that the D85Y polymorphism of UGT2B15 and CNVs in UGT2B28 and UGT2B17 genes is not associated with prostate cancer risk in Iranian patients.
The androgen-inactivating UGT2B28 enzyme influences hormone levels, clinical and pathologic factors, and the risk of prostate cancer progression.
UGT2B28 was clearly detected in breast and adipose tissue; GT2B28 expression in the breast was comparatively low, about 1.6% of GAPDH (show GAPDH Antibodies) mRNA levels, and was less than 5% of normalized (against GAPDH (show GAPDH Antibodies)) UGT2B7 (show UGT2B7 Antibodies) and 2B10 mRNA expression levels in the liver
Copy-number variations (CNVs) of the human sex steroid metabolizing genes UGT2B28
This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Two transcript variants encoding different isoforms have been found for this gene. While both isoforms are targeted to the endoplasmic reticulum, only the longer isoform appears to be active.
UDP glycosyltransferase 2 family, polypeptide B28
, UDP-glucuronosyltransferase 2B28
, UDPGT 2B28
, UDP glucuronosyltransferase 2 family, polypeptide B11