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Browse our BMP4 Proteins (BMP4)

Full name:
Bone Morphogenetic Protein 4 Proteins (BMP4)
On www.antibodies-online.com are 67 Bone Morphogenetic Protein 4 (BMP4) Proteins from 19 different suppliers available. Additionally we are shipping BMP4 Antibodies (272) and BMP4 Kits (112) and many more products for this protein. A total of 460 BMP4 products are currently listed.
Synonyms:
bmp-2, BMP-4, bmp2, bmp2-4, Bmp2b, Bmp2b-1, Bmp2b1, BMP4, BOMPR4A, cb670, MCOPS6, OFC11, XBMP-4, xbmp4, zbmp-2, zbmp-4, zbmp2, zgc:100779, ZYME
list all proteins Gene Name GeneID UniProt
BMP4 652 P12644
BMP4 12159 P21275
BMP4 25296  

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BMP4 Proteins (BMP4) by Origin

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Top referenced BMP4 Proteins

  1. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2667382 : Labeur, Páez-Pereda, Haedo, Arzt, Stalla: Pituitary tumors: cell type-specific roles for BMP-4. in Molecular and cellular endocrinology 2010 (PubMed)
    Show all 6 references for ABIN2667382

  2. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2666448 : Haubold, Weise, Stephan, Dünker: Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. in International journal of biological sciences 2010 (PubMed)
    Show all 5 references for ABIN2666448

  3. Mouse (Murine) BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2666446 : Chen, Zhao, Mundy: Bone morphogenetic proteins. in Growth factors (Chur, Switzerland) 2004 (PubMed)
    Show all 4 references for ABIN2666446

  4. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN666737 : Li, Zhang, Xu, Zhang, Kang, Zhao: Treatment of rabbit femoral defect by firearm with BMP-4 gene combined with TGF-beta1. in The Journal of trauma 2009 (PubMed)
    Show all 2 references for ABIN666737

  5. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN413086 : Riesco, Valcarce, Alfonso, Herráez, Robles: In vitro generation of zebrafish PGC-like cells. in Biology of reproduction 2014 (PubMed)

More Proteins for BMP4 Interaction Partners

Zebrafish Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Data show that transcription of organizer-specific bone morphogenetic protein 2b (bmp2b) is directly down-regulated by Nodal and up-regulated by Wnt (show WNT2 Proteins) signal.

  2. Structures of Bmp2a (show BMP2 Proteins), Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.

  3. FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a (show GREM1 Proteins).

  4. Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development.

  5. BMP2b signaling in zebrafish embryos substantially decreases emergence of lymphatic endothelial cells.

  6. Data show that BMP2B protein is expressed in a gradient as early as blastula stages.

  7. we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart

  8. The Bmp2b mutants and mosaic loss-of-function experiments reveal that BMP acts as a repressor of eye-field fate through inhibition of its key transcription factor Rx3, thereby protecting the future telencephalon from acquiring eye identity.

  9. bmp2b is involved in dorsal retina initiation, acting upstream of gdf6a.

  10. Results show that BMP2b down-regulates fshr (show FSHR Proteins) while up-regulating lhr (show LHCGR Proteins).

Xenopus laevis Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Data indicate that bone morphogenetic protein (BMP) signaling is essential for erythroid differentiation, and in the absence of BMP signaling, precursor cells adopt an endothelial cell (EC) fate.

  2. Osr1 (show OSR1 Proteins)/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.

  3. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.

  4. PIAS (show PIAS1 Proteins) proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8 (show WNT8A Proteins).

  5. Data show that PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.

  6. BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.

  7. Data suggest that the feedback inhibitors BAMBI (show BAMBI Proteins), SMAD6 (show SMAD6 Proteins), and SMAD7 (show SMAD7 Proteins) expand the dynamic BMP4 signaling range essential for proper embryonic patterning and reduce interindividual phenotypic and molecular variability in Xenopus embryos.

  8. limits homeobox (show PRRX1 Proteins) gene expression in the organiser/non-organiser direction

  9. X-epilectin expression is down-regulated by Noggin (show NOG Proteins) and tBR and that this effect is inhibited by BMP4 over-expression

  10. BMP4-dependent expression of Xenopus Grainyhead-like 1 (show GRHL1 Proteins) has a critical role in epidermal differentiation

Horse (Equine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. BMP4 signaling plays a role in the regulation of terminal differentiation of primary equine trophoblast cells via activation of the SMAD1 (show SMAD1 Proteins)/5 pathway

Human Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. In solid ameloblastoma, positive correlations were observed between the stromal and parenchymal expression of BMP-2 (show BMP2 Proteins) and between the stromal expression of BMP-2 (show BMP2 Proteins) and BMP-4, as well as between the stromal expression of BMPR-II (show BMPR2 Proteins) and BMP-4 and the stromal and parenchymal expression of BMPR-II (show BMPR2 Proteins).

  2. The BMP2 (show BMP2 Proteins) rs235768 A>T and BMP4 rs17563 T>C polymorphisms could be considered as the risk factor for non-syndromic CL/P in Iranian population.

  3. BMP4 GAAA (p=0.05) and GGGA (p=0.02) haplotypes were associated with peri (show PLIN1 Proteins)-implantitis (p=0.03). Therefore, it may be concluded that BMP4 and FGF10 (show FGF10 Proteins) haplotypes are associated with peri (show PLIN1 Proteins)-implantitis

  4. BMP4 inhibited ERalpha (show ESR1 Proteins) signaling by increasing the degradation of ERalpha (show ESR1 Proteins), and that the expression of BMP4 itself was suppressed by estrogens.

  5. study shows that patients with CRA (show MTMR11 Proteins) had high expression of BMP6 (show BMP6 Proteins) and hepcidin (show HAMP Proteins) and low expression of s-HJV (show HFE2 Proteins). BMP6 (show BMP6 Proteins) was found to be negatively correlated with s-HJV (show HFE2 Proteins); both regulate hepcidin (show HAMP Proteins) expression and play important roles in the development of anemia.

  6. we have for the first time characterized the BMP4-induced miRNA expression profiles in breast cancer cell lines, showing that induced miRNAs contribute to the fine-tuning of proliferation and migration phenotypes.

  7. BMP4 caused a trend towards accelerated metastasis formation, especially in bone. More work is needed to uncover the long-term effects of BMP4 and the clinical relevance of these findings.

  8. BMP4 is a direct thyroid hormone (show PTH Proteins) target and is involved in a positive autoregulatory feedback loop that modulates thyroid hormone (show PTH Proteins) signaling

  9. An up-regulated expression of BMP-4 and BMPR-II (show BMPR2 Proteins) was observed in the peripheral blood of breast cancer patients especially in the advanced-stage of the disease. Moreover, BMP-4 and BMPR-II (show BMPR2 Proteins) expressions were found to be correlated

  10. PDGF (show PDGFA Proteins)-AA impairs endothelium-dependent vasodilation and PDGF (show PDGFA Proteins)-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1 (show GARS Proteins)/5- and SMAD4 (show SMAD4 Proteins)-dependent mechanisms.

Mouse (Murine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Western blot analysis demonstrated that following BMP2 (show BMP2 Proteins) and BMP7 (show BMP7 Proteins) cotransfection of MC3T3E1 cells, the protein expression levels of BMP2 (show BMP2 Proteins), BMP4, BMP6 (show BMP6 Proteins), BMP7 (show BMP7 Proteins), BMP9 (show GDF2 Proteins) and Wnt3a (show WNT3A Proteins) were increased compared with control cells

  2. BMP4 inhibited ERalpha (show ESR1 Proteins) signaling by increasing the degradation of ERalpha (show ESR1 Proteins), and that the expression of BMP4 itself was suppressed by estrogens.

  3. the present study suggested that miRNA378 is critical for the promotion of myoblast differentiation by targeting BMP4.

  4. Increased BMP signaling contributes significantly to impairments in neurogenesis and to cognitive decline associated with aging

  5. findings suggest that Sox6 contributes to cell survival by suppressing BMP-4 transcription during neuronal differentiation

  6. Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).

  7. Ino80 represses Bmp4 expression during embryonic stem cell differentiation.

  8. only BMP7 (show BMP7 Proteins), not BMP2 (show BMP2 Proteins) or BMP4, is necessary for interdigital programmed cell death

  9. Report phenotype of BMP2/4 double knockout osteoblast cell line.

  10. PDGF (show PDGFA Proteins)-AA impairs endothelium-dependent vasodilation and PDGF (show PDGFA Proteins)-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1 (show SMAD1 Proteins)/5- and SMAD4 (show SMAD4 Proteins)-dependent mechanisms.

Cow (Bovine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog (show DDX4 Proteins) expression in differentiating bovine induced pluripotent stem cells.

  2. The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 (show SLC6A8 Proteins) cell growth

  3. BMP4 during maturation increased the proportion of Oct-4 (show POU5F1 Proteins) positive cells in parthenogenic embryos. BMP4 is implicated in bovine oocytes maturation and embryo development.

  4. analysis of polymorphic CA microsatellites in the third exon of the bovine BMP4 gene

  5. concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than in oocyte maturation

  6. Data report that BMP-7 (show BMP7 Proteins) suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD (show DFFB Proteins)) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD.

  7. Heat shock protein 70 (show HSP70 Proteins) enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein (show MGP Proteins).

Goat Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. A microsatellite (ACn (show ACIN1 Proteins)) was identified in the 3' UTR of BMP4 gene.Prolificacy associated microsatellite (AC19 (show POLR1D Proteins)) was detected in Indian goats.

Pig (Porcine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. paracrine signals from the embryo, represented by FGF4 (show FGF4 Proteins) and BMP4, induce a response in the trophoblast prior to the extensive elongation.

  2. The structure of porcine BMP4 gene is highly conservative with other mammalian BMP4 genes, but some differences may be present in the regulation of gene expression.

  3. Altered shear stress stimulates upregulation of endothelial VCAM-1 (show VCAM1 Proteins) and ICAM-1 (show ICAM1 Proteins) in a BMP-4- and TGF-beta1 (show TGFB1 Proteins)-dependent pathway.

Rabbit Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. The TM-induced characteristic changes in the expression pattern of Hoxa11 (show HOXA11 Proteins) and Bmp4 on GDs (show PAEP Proteins) 10 and/or 11 were not noted.

  2. BMP4 is expressed peripherally in hypoblast and epiblast and in the mesoderm at the posterior pole of the embryonic disc.

  3. Data show that BMP-2 (show BMP2 Proteins), BMP-4, and BMP-7 (show BMP7 Proteins), noggin (show NOG Proteins), and chordin (show CHRD Proteins) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.

  4. Both of the adenovirus-containing bone morphogenetic protein transduced MSCs expressed BMP4 mRNA and protein and underwent osteogenic differentiation.

BMP4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Alternative names and synonyms associated with BMP4

  • bone morphogenetic protein 4 (bmp4)
  • bone morphogenetic protein 4 (bmp4-a)
  • bone morphogenetic protein 4 (BMP4)
  • Bone morphogenetic protein 4 (bmp4)
  • bone morphogenetic protein 4 (LOC100286408)
  • bone morphogenetic protein 2b (bmp2b)
  • bone morphogenetic protein 4 (bmp4-b)
  • bone morphogenetic protein 4 (Bmp4)
  • bmp-2 protein
  • BMP-4 protein
  • bmp2 protein
  • bmp2-4 protein
  • Bmp2b protein
  • Bmp2b-1 protein
  • Bmp2b1 protein
  • BMP4 protein
  • BOMPR4A protein
  • cb670 protein
  • MCOPS6 protein
  • OFC11 protein
  • XBMP-4 protein
  • xbmp4 protein
  • zbmp-2 protein
  • zbmp-4 protein
  • zbmp2 protein
  • zgc:100779 protein
  • ZYME protein

Protein level used designations for BMP4

etID309887.17 , bone morphogenetic protein-4 , bone morphogenetic protein 4 , bone morphogenetic protein 4, isoform 3 , Bone morphogenetic protein 4 , bone morphogenetic protein 4-like , bone morphogenetic protein 2 , etID309839.20 , swirl , swr , BMP-2B , BMP-4 , bone morphogenetic protein 2B

GENE ID SPECIES
30612 Danio rerio
397874 Xenopus laevis
452912 Pan troglodytes
549788 Xenopus (Silurana) tropicalis
100034048 Equus caballus
100049354 Oryzias latipes
100137596 Papio anubis
100194815 Salmo salar
100221891 Taeniopygia guttata
100398270 Callithrix jacchus
100286408 Salmo salar
100449444 Pongo abelii
30632 Danio rerio
652 Homo sapiens
399322 Xenopus laevis
12159 Mus musculus
25296 Rattus norvegicus
407216 Bos taurus
490695 Canis lupus familiaris
100860789 Capra hircus
100113425 Sus scrofa
396165 Gallus gallus
100009569 Oryctolagus cuniculus
100733516 Cavia porcellus
443502 Ovis aries
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