Browse our BMP4 Proteins (BMP4)

Full name:
Bone Morphogenetic Protein 4 Proteins (BMP4)
On www.antibodies-online.com are 75 Bone Morphogenetic Protein 4 (BMP4) Proteins from 20 different suppliers available. Additionally we are shipping BMP4 Antibodies (278) and BMP4 Kits (122) and many more products for this protein. A total of 485 BMP4 products are currently listed.
Synonyms:
bmp-2, BMP-4, bmp2, bmp2-4, Bmp2b, Bmp2b-1, Bmp2b1, BMP4, BOMPR4A, cb670, MCOPS6, OFC11, XBMP-4, xbmp4, zbmp-2, zbmp-4, zbmp2, zgc:100779, ZYME
list all proteins Gene Name GeneID UniProt
BMP4 652 P12644
BMP4 12159 P21275
BMP4 25296  

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BMP4 Proteins (BMP4) by Origin

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Top referenced BMP4 Proteins

  1. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2667382 : Labeur, Páez-Pereda, Haedo, Arzt, Stalla: Pituitary tumors: cell type-specific roles for BMP-4. in Molecular and cellular endocrinology 2010 (PubMed)
    Show all 6 references for 2667382

  2. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2666448 : Haubold, Weise, Stephan, Dünker: Bone morphogenetic protein 4 (BMP4) signaling in retinoblastoma cells. in International journal of biological sciences 2010 (PubMed)
    Show all 5 references for 2666448

  3. Mouse (Murine) BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN2666446 : Chen, Zhao, Mundy: Bone morphogenetic proteins. in Growth factors (Chur, Switzerland) 2004 (PubMed)
    Show all 4 references for 2666446

  4. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN666737 : Li, Zhang, Xu, Zhang, Kang, Zhao: Treatment of rabbit femoral defect by firearm with BMP-4 gene combined with TGF-beta1. in The Journal of trauma 2009 (PubMed)
    Show all 2 references for 666737

  5. Human BMP4 Protein expressed in Escherichia coli (E. coli) - ABIN413086 : Riesco, Valcarce, Alfonso, Herráez, Robles: In vitro generation of zebrafish PGC-like cells. in Biology of reproduction 2014 (PubMed)

More Proteins for BMP4 Interaction Partners

Zebrafish Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Study found that BMP-2 is negatively regulated by miR (show MYLIP Proteins)-140 during early embryogenesis and bone development in zebra fi sh.

  2. Data show that transcription of organizer-specific bone morphogenetic protein 2b (bmp2b) is directly down-regulated by Nodal and up-regulated by Wnt (show WNT2 Proteins) signal.

  3. Structures of Bmp2a (show BMP2 Proteins), Bmp2b, Bmp4 and Bmp16 were found to be remarkably similar; with residues involved in receptor binding being highly conserved.

  4. FGF signaling in establishment of the developmental hematopoietic stem cell niche occurs via inhibition of bmp4 transcription, and activation of bmp antagonists, nog2 and grem1a (show GREM1 Proteins).

  5. Organizer-derived Bmp2 is required for the formation of a correct Bmp activity gradient during embryonic development.

  6. BMP2b signaling in zebrafish embryos substantially decreases emergence of lymphatic endothelial cells.

  7. Data show that BMP2B protein is expressed in a gradient as early as blastula stages.

  8. we identify a previously unappreciated role for the Nodal-transcription factor FoxH1 in mediating cell responsiveness to Bmp further linking the control of these two pathways in the heart

  9. The Bmp2b mutants and mosaic loss-of-function experiments reveal that BMP acts as a repressor of eye-field fate through inhibition of its key transcription factor Rx3, thereby protecting the future telencephalon from acquiring eye identity.

  10. bmp2b is involved in dorsal retina initiation, acting upstream of gdf6a.

Xenopus laevis Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Data indicate that bone morphogenetic protein (BMP) signaling is essential for erythroid differentiation, and in the absence of BMP signaling, precursor cells adopt an endothelial cell (EC) fate.

  2. Osr1 (show OSR1 Proteins)/Osr2 normally repress bmp4 expression in the lateral plate mesoderm prior to respiratory specification.

  3. The results suggest that DeltaNp63 is an essential gene in early epidermal specification under the control of BMP4.

  4. PIAS (show PIAS1 Proteins) proteins have differential ability to regulate signals from the growth factors activin, bone morphogenetic protein 4 (BMP4), and Wnt8 (show WNT8A Proteins).

  5. Data show that PV.1A undergoes combinatorial regulation during early Xenopus development as both the direct target of BMP-4 signaling and as the direct and indirect target of positive and negative regulatory factors.

  6. BMP inhibition is sufficient for neural induction in vivo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain formation.

  7. Data suggest that the feedback inhibitors BAMBI (show BAMBI Proteins), SMAD6 (show SMAD6 Proteins), and SMAD7 (show SMAD7 Proteins) expand the dynamic BMP4 signaling range essential for proper embryonic patterning and reduce interindividual phenotypic and molecular variability in Xenopus embryos.

  8. limits homeobox (show PRRX1 Proteins) gene expression in the organiser/non-organiser direction

  9. X-epilectin expression is down-regulated by Noggin (show NOG Proteins) and tBR and that this effect is inhibited by BMP4 over-expression

  10. BMP4-dependent expression of Xenopus Grainyhead-like 1 (show GRHL1 Proteins) has a critical role in epidermal differentiation

Horse (Equine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. BMP4 signaling plays a role in the regulation of terminal differentiation of primary equine trophoblast cells via activation of the SMAD1 (show SMAD1 Proteins)/5 pathway

Human Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. RUNX1T1 (show RUNX1T1 Proteins) serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  2. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.

  3. Meta-analysis to assess the effect of BMP4 rs17563 polymorphism on nonsyndromic cleft lip with or without cleft palate (NSCL (show NHLH1 Proteins)/P) suggests that the C allele of BMP4 rs17563 may be a risk factor for NSCL (show NHLH1 Proteins)/P among Asians and Caucasians, and may be a protective factor for NSCL (show NHLH1 Proteins)/P in Brazilian population.

  4. this study identified BMP-4 as a potential molecular marker for predicting the invasion and progression of papillary thyroid carcinoma

  5. Bmp4 drives terminal differentiation into mature white rather than brown fat cells. Bmp4 seems to have a dual role in metabolism either promoting or repressing oxidative metabolism in a cell context dependent manner.

  6. Data suggest that serum BMP4 levels are associated with visceral adiposity and may play role in fat distribution; role of BMP4 in males and females may be different; visceral adiposity may predict serum BMP4 levels in females with obesity; serum BMP4 levels are decreased after GLP-1 receptor (show GLP1R Proteins) agonist (exenatide) treatment in obesity. This study was conducted in China.

  7. BMP4 is a potential cause of digital and eye abnormalities in familial dopa-responsive dystonia.

  8. BMP4 expression was significantly upregulated in esophageal adenocarcinoma and Barrett's esophagus. BMP4 incubation inhibited cell viability,induced cell migration adnd upregulated SNAIL2 expression.

  9. the data identify MxA (show MX1 Proteins) as a novel stimulator of BMP4 and BMP9 (show GDF2 Proteins) transcriptional signaling, and suggest it to be a candidate IFN-alpha (show IFNA Proteins)-inducible mechanism that might have a protective role against development of pulmonary arterial hypertension and other vascular diseases.

  10. The 6007C>T polymorphism of BMP-4, -66T>G polymorphism of OPN (show SPP1 Proteins), and VDR (show CYP27B1 Proteins)-FokI polymorphism are the susceptible factors of spinal TB and indicators of the clinical severity. These three genes may collaborate in the development of spinal TB.

Mouse (Murine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. RUNX1T1 (show RUNX1T1 Proteins) serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  2. Expression of Bmp4 in the ureteric mesenchyme depends on HH signaling and Foxf1 (show FOXF1 Proteins), and that exogenous BMP4 rescued cell proliferation and epithelial differentiation in ureters with abrogated HH signaling or FOXF1 (show FOXF1 Proteins) function.

  3. the effect of titanium (Ti) with nanotopography (Nano) on the endogenous expression of BMP-2 (show BMP2 Proteins) and BMP-4 and the relevance of this process to the nanotopography-induced osteoblast differentiation.

  4. These data indicate that Foxc1 (show FOXC1 Proteins) expression is regulated by BMP4 and FOXC1 (show FOXC1 Proteins) functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds.

  5. Phosphorylated Smad1/5/8/9 specifically bound to the BREs of Smad8/9 gene. The present study reveals that Smad8/9 is a unique R-Smad regulated through the BMP pathway at the mRNA level.

  6. Treatment of ES cells with TPO (show THPO Proteins) induced the autocrine production of BMP4 with concomitant upregulation of the BMP receptor BMPR1A (show BMPR1A Proteins), phosphorylation of SMAD1 (show SMAD1 Proteins), 5, 8, and activation of specific BMP4 target genes; this was mediated by TPO (show THPO Proteins)-dependent binding of transcription factor HIF-1alpha (show HIF1A Proteins) to the BMP4 gene promoter.

  7. Data suggest that ovarian Bmp4 levels are significantly decreased in a mouse model of polycystic ovary syndrome with hyperandrogenism; androgens inhibited Bmp4 expression via activation of androgen receptors; Smad4 (show SMAD4 Proteins) signaling rather than p38 MAPK (show MAPK14 Proteins) pathway regulates androgen and estrogen formation.

  8. tightly spatial interaction of FSTL1 (show FSTL1 Proteins) and BMP4 signaling plays an essential role in lung development

  9. this study identified Bmp4 as a significant factor for improved maintenance of Foxn1 (show FOXN2 Proteins) expression, promotion of thymic epithelial progenitor populations self-renewal and immature epithelial cell differentiation and survival

  10. these data reveal a novel mechanism that the Bmp4-Msx1 (show MSX1 Proteins) pathway and Osr2 control tooth organogenesis through antagonistic regulation of expression of secreted Wnt (show WNT2 Proteins) antagonists.

Cow (Bovine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. Bone morphogenetic protein 4 and retinoic acid trigger bovine VASA homolog (show DDX4 Proteins) expression in differentiating bovine induced pluripotent stem cells.

  2. The BMP2/4 ligand and receptor system presides within bovine trophectoderm prior to uterine attachment. BMP4 negatively impacts CT1 (show SLC6A8 Proteins) cell growth

  3. BMP4 during maturation increased the proportion of Oct-4 (show POU5F1 Proteins) positive cells in parthenogenic embryos. BMP4 is implicated in bovine oocytes maturation and embryo development.

  4. analysis of polymorphic CA microsatellites in the third exon of the bovine BMP4 gene

  5. concluded that a bone morphogenetic protein (BMP)-signaling system, consisting of BMP2, BMP4, type II and I receptors, is present in bovine antral follicles and plays a role in development and functioning of follicles rather than in oocyte maturation

  6. Data report that BMP-7 (show BMP7 Proteins) suppresses granulosa cell apoptosis by inhibiting the release of caspase-activated DNase (CAD (show DFFB Proteins)) via a mechanism which does not appear to be associated with the mitochondrial pathway, whereas BMP-4 inhibits the release of CAD.

  7. Heat shock protein 70 (show HSP70 Proteins) enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein (show MGP Proteins).

Goat Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. A microsatellite (ACn (show ACIN1 Proteins)) was identified in the 3' UTR of BMP4 gene.Prolificacy associated microsatellite (AC19 (show POLR1D Proteins)) was detected in Indian goats.

Pig (Porcine) Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. paracrine signals from the embryo, represented by FGF4 (show FGF4 Proteins) and BMP4, induce a response in the trophoblast prior to the extensive elongation.

  2. The structure of porcine BMP4 gene is highly conservative with other mammalian BMP4 genes, but some differences may be present in the regulation of gene expression.

  3. Altered shear stress stimulates upregulation of endothelial VCAM-1 (show VCAM1 Proteins) and ICAM-1 (show ICAM1 Proteins) in a BMP-4- and TGF-beta1 (show TGFB1 Proteins)-dependent pathway.

Rabbit Bone Morphogenetic Protein 4 (BMP4) interaction partners

  1. The TM-induced characteristic changes in the expression pattern of Hoxa11 (show HOXA11 Proteins) and Bmp4 on GDs (show PAEP Proteins) 10 and/or 11 were not noted.

  2. BMP4 is expressed peripherally in hypoblast and epiblast and in the mesoderm at the posterior pole of the embryonic disc.

  3. Data show that BMP-2 (show BMP2 Proteins), BMP-4, and BMP-7 (show BMP7 Proteins), noggin (show NOG Proteins), and chordin (show CHRD Proteins) were colocalized in rimming osteoblasts, osteoclasts, and chondrocytes.

  4. Both of the adenovirus-containing bone morphogenetic protein transduced MSCs expressed BMP4 mRNA and protein and underwent osteogenic differentiation.

BMP4 Protein Profile

Protein Summary

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein.

Alternative names and synonyms associated with BMP4

  • bone morphogenetic protein 4 (bmp4)
  • bone morphogenetic protein 4 (bmp4-a)
  • bone morphogenetic protein 4 (BMP4)
  • Bone morphogenetic protein 4 (bmp4)
  • bone morphogenetic protein 4 (LOC100286408)
  • bone morphogenetic protein 2b (bmp2b)
  • bone morphogenetic protein 4 (bmp4-b)
  • bone morphogenetic protein 4 (Bmp4)
  • bmp-2 protein
  • BMP-4 protein
  • bmp2 protein
  • bmp2-4 protein
  • Bmp2b protein
  • Bmp2b-1 protein
  • Bmp2b1 protein
  • BMP4 protein
  • BOMPR4A protein
  • cb670 protein
  • MCOPS6 protein
  • OFC11 protein
  • XBMP-4 protein
  • xbmp4 protein
  • zbmp-2 protein
  • zbmp-4 protein
  • zbmp2 protein
  • zgc:100779 protein
  • ZYME protein

Protein level used designations for BMP4

etID309887.17 , bone morphogenetic protein-4 , bone morphogenetic protein 4 , bone morphogenetic protein 4, isoform 3 , Bone morphogenetic protein 4 , bone morphogenetic protein 4-like , bone morphogenetic protein 2 , etID309839.20 , swirl , swr , BMP-2B , BMP-4 , bone morphogenetic protein 2B

GENE ID SPECIES
30612 Danio rerio
397874 Xenopus laevis
452912 Pan troglodytes
549788 Xenopus (Silurana) tropicalis
100034048 Equus caballus
100049354 Oryzias latipes
100137596 Papio anubis
100194815 Salmo salar
100221891 Taeniopygia guttata
100398270 Callithrix jacchus
100286408 Salmo salar
100449444 Pongo abelii
30632 Danio rerio
652 Homo sapiens
399322 Xenopus laevis
12159 Mus musculus
25296 Rattus norvegicus
407216 Bos taurus
490695 Canis lupus familiaris
100860789 Capra hircus
100113425 Sus scrofa
396165 Gallus gallus
100009569 Oryctolagus cuniculus
100733516 Cavia porcellus
443502 Ovis aries
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