Browse our anti-Ataxin 1 (ATXN1) Antibodies

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anti-Ataxin 1 Antibodies (ATXN1)
On are 209 Ataxin 1 (ATXN1) Antibodies from 25 different suppliers available. Additionally we are shipping Ataxin 1 Kits (31) and Ataxin 1 Proteins (8) and many more products for this protein. A total of 260 Ataxin 1 products are currently listed.
2900016G23Rik, ataxin 1b, Atx1, atxn1, C85907, CG4547, D6S504E, dAtx-1, dAtx1, Dmel\\CG4547, ENSMUSG00000074917, Gm10786, sca1
list all antibodies Gene Name GeneID UniProt
ATXN1 6310 P54253
ATXN1 20238 P54254
ATXN1 25049 Q63540

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anti-Human Ataxin 1 Antibodies:

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anti-Rat (Rattus) Ataxin 1 Antibodies:

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Top referenced anti-Ataxin 1 Antibodies

  1. Human Monoclonal Ataxin 1 Primary Antibody for EIA, FACS - ABIN1105458 : Krishna, Mohan, Yashavantha, Rammurthy, Kiran Kumar, Mittal, Tyagi, Mukerji, Jain, Pal, Purushottam: SCA 1, SCA 2 & SCA 3/MJD mutations in ataxia syndromes in southern India. in The Indian journal of medical research 2007 (PubMed)
    Show all 4 references for 1105458

  2. Human Polyclonal Ataxin 1 Primary Antibody for EIA, WB - ABIN357975 : Lim, Crespo-Barreto, Jafar-Nejad, Bowman, Richman, Hill, Orr, Zoghbi: Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1. in Nature 2008 (PubMed)
    Show all 2 references for 357975

  3. Human Polyclonal Ataxin 1 Primary Antibody for IF, WB - ABIN389309 : Hong, Lee, Cho, Kang: UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 references for 389309

  4. Human Polyclonal Ataxin 1 Primary Antibody for IF, IHC - ABIN1532502 : Mungall, Palmer, Sims, Edwards, Ashurst, Wilming, Jones, Horton, Hunt, Scott, Gilbert, Clamp, Bethel, Milne, Ainscough, Almeida, Ambrose, Andrews, Ashwell, Babbage, Bagguley, Bailey, Banerjee, Barker et al.: The DNA sequence and analysis of human chromosome 6. ... in Nature 2003 (PubMed)

More Antibodies against Ataxin 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Ataxin 1 (ATXN1) interaction partners

  1. Ataxin-1 induces intranuclear accumulation of dAtx2/hAtaxin-2 in both Drosophila and SCA1 postmortem neurons

  2. mutant ataxin-1 and huntingtin (show HTT Antibodies) induce developmental and late-onset neuronal pathologies in Drosophila models

Human Ataxin 1 (ATXN1) interaction partners

  1. data suggest GSK3b (show GSK3b Antibodies) and mTOR (show FRAP1 Antibodies) pathways modulate this ATXN1 function in spinocerebellar ataxia (show USP14 Antibodies) type-1 (SCA1)pathogenesis that could be targeted therapeutically prior to the onset of disease symptoms in SCA1 and other pathologies involving dysregulation of ATXN1 functions.

  2. SCA1 phenotypes could be reversed by partial suppression of human mutant ATXN1 mRNA by rAAV.miS1 when delivered after symptom onset in mice.

  3. SCA1 relative frequency in Poland shows the highest value compared with the data from other countries worldwide in patient with Spinocerebellar ataxias

  4. Studied Ataxin-1 using molecular modeling to investigate the protein-protein interactions contributing to the AXH domain dimer stability.

  5. Data indicate that in spinocerebellar ataxia (show USP14 Antibodies) type 1 patients the spinocerebellar ataxia type 1 protein trinucleotide repeat expansion (CAG)n was great than 39, comparing with normal 6-38.

  6. This study reports the results of molecular dynamics simulations of AXH monomer of Ataxin-1.

  7. Systematic replacement of each lysine residue in the AXH domain revealed that the lysine at 589 (K589) of ATXN1 is essential for its ubiquitylation by UbcH6 (show UBE2E1 Antibodies).

  8. Results show that two SNPs in ATXN1 gene have a founder effect of the same repeat carrying allele as in the general Indian population suggesting that that Spinocerebellar ataxia (show USP14 Antibodies) type 1 disease onset is significantly delayed when transmission is maternal.

  9. this work provides the structural and molecular basis of the interaction between RBM17 (show RBM17 Antibodies) and the phosphorylated form of ATXN1.

  10. Partner recognition of the AXH domain of the transcriptional co-regulator ataxin-1 is fine-tuned by a subtle balance between self- and hetero-associations.

Mouse (Murine) Ataxin 1 (ATXN1) interaction partners

  1. data suggest GSK3b (show GSK3b Antibodies) and mTOR (show FRAP1 Antibodies) pathways modulate this ATXN1 function in spinocerebellar ataxia (show USP14 Antibodies) type-1 (SCA1)pathogenesis that could be targeted therapeutically prior to the onset of disease symptoms in SCA1 and other pathologies involving dysregulation of ATXN1 functions.

  2. Maternal diabetes induced caspase 3 (show CASP3 Antibodies)-dependent apoptosis in Sca1(+) cardiac progenitor cells derived from embryonic day 17.5 (E17.5). Both maternal diabetes and high glucose in vitro activated the pro-apoptotic transcription factor, Forkhead O 3a (FoxO3a (show FOXO3 Antibodies)) via dephosphorylation at threonine 32 (Thr (show TRH Antibodies)-32) residue.

  3. Data establish a novel role for ATXN1 in the hippocampus as an intrinsic regulator of precursor cell proliferation, and suggest a mechanism by which polyQ expansion and loss of ATXN1 affect hippocampal function, potentially contributing to cognitive deficits and depression

  4. The results of this study found that upregulation of cholecystokinin (Cck (show CCK Antibodies)) and subsequent interaction with the Cck1 (show CCL28 Antibodies) receptor likely underlies the lack of progressive Purkinje cell pathology in Pcp2-ATXN1[30Q]D776 mice.

  5. Mutant ATXN1 forms oligomers whose levels correlate with disease progression in the Atxn1154Q/+ mice.

  6. The study showed that Sca1(+)Lin(-) bone marrow contains an endodermal precursor population of cells that differentiates into hepatocytes.

  7. HMGB1 (show HMGB1 Antibodies) facilitates repair of mitochondrial DNA damage of mutant ataxin-1 knock-in mice.

  8. The RNA-binding protein PUMILIO1 (PUM1 (show PUM1 Antibodies)) not only directly regulates ATAXIN1 but also plays an unexpectedly important role in neuronal function. Loss of Pum1 (show PUM1 Antibodies) caused progressive motor dysfunction and SCA1-like neurodegeneration with motor impairment, primarily by increasing Ataxin1 levels.

  9. study found a new function of ataxin-1: the modulation of Pp2a (show PPP2R2B Antibodies) activity and the regulation of its holoenzyme composition, with the polyglutamine mutation within Atxn1 altering this function in the spinocerebellar ataxia (show USP14 Antibodies) type 1 mouse cerebellum before disease onset

  10. Delivery of either ataxin-1-like (show ATXN1L Antibodies) viral vectors to Spinocerebellar Ataxia (show USP14 Antibodies) Type 1 mice cerebella resulted in widespread cerebellar Purkinje cell transduction

Ataxin 1 (ATXN1) Antigen Profile

Antigen Summary

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1). At least two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with Ataxin 1 (ATXN1)

  • ataxin 1 (ATXN1) antibody
  • ataxin 1b (atxn1b) antibody
  • Ataxin 1 (Atx-1) antibody
  • ataxin 1 (Atxn1) antibody
  • ataxin 1-like (ATXN1L) antibody
  • 2900016G23Rik antibody
  • ataxin 1b antibody
  • Atx1 antibody
  • atxn1 antibody
  • C85907 antibody
  • CG4547 antibody
  • D6S504E antibody
  • dAtx-1 antibody
  • dAtx1 antibody
  • Dmel\\CG4547 antibody
  • ENSMUSG00000074917 antibody
  • Gm10786 antibody
  • sca1 antibody

Protein level used designations for anti-Ataxin 1 (ATXN1) Antibodies

ataxin 1 , spinocerebellar ataxia type 1 , Ataxin1 , Atx-1-PB , CG4547-PB , ataxin-1 , ataxin-1-like , spinocerebellar ataxia type 1 protein , spinocerebellar ataxia 1 homolog , spinocerebellar ataxia 1 , spinocerebellar ataxia type 1 protein homolog , spinocerebellar ataxia type 1 protien

100065748 Equus caballus
493678 Felis catus
565841 Danio rerio
747421 Pan troglodytes
31624 Drosophila melanogaster
100025666 Monodelphis domestica
100402564 Callithrix jacchus
100437511 Pongo abelii
100467930 Ailuropoda melanoleuca
100588152 Nomascus leucogenys
6310 Homo sapiens
20238 Mus musculus
25049 Rattus norvegicus
488232 Canis lupus familiaris
100154571 Sus scrofa
616399 Bos taurus
100719683 Cavia porcellus
420843 Gallus gallus
101113284 Ovis aries
489725 Canis lupus familiaris
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