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Data show that MiR (show MLXIP Proteins)-422a and its target CD73 are involved in early loco(regional) recurrence of head and neck squamous cell carcinoma (HNSCC) tumors and are targets for personalized medicine.
HPV+ cervical cancer cells express higher levels of CD73 than HPV- cells, and this expression is associated with the production of larger amounts of adenosine, as well as a stronger inhibition of proliferation, activation, and cytotoxic activity of CD8 (show CD8A Proteins)+ T cells via interaction with A2A adenosine receptor
Endogenous Plastic Somatic (ePS) cells in a latent state, i.e. lacking SOX2 (show SOX2 Proteins), OCT3/4 (show POU5F1 Proteins) and NANOG (show NANOG Proteins) (SON) expression, in non-diseased breast specimens through immunohistochemical analysis of previously identified ePS-specific biomarkers (CD73(+), EpCAM (show EPCAM Proteins)(+) and CD90 (show THY1 Proteins)(-)).
Down-regulation of CD73 on B cells of patients with viremic HIV correlates with B cell activation (show BLNK Proteins) and disease progression.
CD73 expression is upregulated in NSCLC and is correlated with a decrease in miR (show MLXIP Proteins)-30a-5p expression.
concluded that CD39 (show ENTPD1 Proteins) and CD73 are molecular targets for the development of drugs for ALF (show GTF2A1L Proteins) patients care
Genetic polymorphism of NT5E may contribute to the pathogenesis of calcific aortic valve disease.
Oxidized low density lipoproteins modulate CD39 (show ENTPD1 Proteins) and CD73 activity in the endothelium.
This study aimed to investigate the activities of purinergic system ecto (show TRIM33 Proteins)-enzymes present on the platelet surface as well as CD39 (show ENTPD1 Proteins) and CD73 expressions on platelets of sickle cell anemia treated patients.
CD73 promotes the growth of human colorectal cancer cells through EGFR (show EGFR Proteins) and the b-catenin/cyclin D1 (show CCND1 Proteins) signaling pathway. CD73 may be used as a valuable biomarker of colorectal cancer.
enzymatic properties of an ecto-5'-nucleotidase (show ACPP Proteins) activity in brain membranes of zebrafish
study concludes that dictyocaulosis alters NTPDase, 5'-nucleotidase, and ADA (show ADA Proteins) activities of cow naturally infected by the parasite Dictyocaulus viviparus, in consequence the enzymes act as inflammatory markers
The 5'-ectonucleotidase CD73 has a key role in regulating macrophage immune responses during efferocytosis by converting AMP (show TMPRSS5 Proteins) released from apoptotic cells into adenosine to suppress multiple pro-inflammatory cytokines.
CD73 expression identifies a subset of IgM (show CD40LG Proteins)(+) antigen-experienced cells with memory attributes that is T cell and CD40 (show CD40 Proteins) signalling dependent
Data show that AMP deaminase 3 (Ampd3 (show AMPD3 Proteins))-/-/5'-nucleotidase (CD73)-/- knockout mice are more sensitive to AMP (show TMPRSS5 Proteins)-induced hypometabolism than mice with a single enzyme deficiency, which are more sensitive than wild type.
Deletion of CD39 (show ENTPD1 Proteins) and CD73 or both caused an inhibition of the microglia ramified phenotype in the brain with a reduction in the length of processes, branching frequency and number of intersections with Sholl spheres. In vitro, unlike wild-type microglia, cd39 (show ENTPD1 Proteins)-/- and cd73-/- microglial cells were less complex and did not respond to ATP with the transformation into a more ramified phenotype.
High NT5E expression is associated with Radiation-Induced Lung Fibrosis.
Ablation of CD73 minimally effects in vivo thrombosis, but increased CD39 (show ENTPD1 Proteins) expression on hematopoietic-derived cells, especially monocytes, attenuates in vivo arterial thrombosis.
Ecto-5'-nucleotidase (show ACPP Proteins) mRNA levels were found to be diminished in both MT1 (show MT1 Proteins) and MT1 (show MT1 Proteins)/2 knockout mice.
Data indicate that adenosine and CGS21680 upregulate CD39 (show ENTPD1 Proteins) and CD73 via E2F-1 (show E2F1 Proteins) and CREB (show CREB1 Proteins).
CD73-siRNA-loaded ChLa NPs (show NPS Proteins) may be considered as a promising therapeutic tool for cancer therapy; however, further in vivo investigations are necessary
These data reveal a novel function of CD73 ectonucleotidase in arresting CD8 (show CD8A Proteins)(+) T-cell differentiation and support the idea that CD73-driven adenosine production by Tc17 cells may promote stem cell-like properties in Tc17 cells.
CD39 (show ENTPD1 Proteins) and CD73 and their enzymatic activities that convert extracellular nucleotides are highly expressed and could have special function in the valve
The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.
, Purine 5-Prime-Nucleotidase
, 5' nucleotidase, ecto
, 5'-nucleotidase, ecto (CD73)
, autoimmune infertility-related protein
, cytosolic 5'-nucleotidase 1B
, cytosolic 5'-nucleotidase IB