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Human CHRM3 ELISA Kit for Sandwich ELISA - ABIN417246
Agha-Hosseini, Mirzaii-Dizgah, Mohammadpour: Muscarinic cholinergic receptors (MR3) in saliva of patients with oral lichen planus. in Archives of dermatological research 2016
this study shows that anti-M3R (show CHRM4 ELISA Kits) is significantly elevated in Sjogren's syndrome plasma in comparison with rheumatoid arthritis, systemic lupus erythematosus, and healthy controls
Interacting post-muscarinic receptor (show CHRM5 ELISA Kits) signaling pathways potentiate MMP1 (show MMP1 ELISA Kits) expression and invasion of human colon cancer cells.
M3R (show CHRM4 ELISA Kits) expression plays an important role in early progression and invasion of colon neoplasia but is less important once tumors have spread.
This study presents the endocytic pathways of internalization for muscarinic type 3 receptor and flotillin-1 (show FLOT1 ELISA Kits)/2 in salivary gland epithelial cells. knockdown of flot-1 (show FLOT1 ELISA Kits) or -2 by flotillin (show FLOT2 ELISA Kits)-specific siRNA prevented internalization and reduced the endocytic efficiency of muscarinic type 3 receptor.
M3-mAChR activation leads to enhancement of hsp expression via PKC-dependent phosphorylation of HSF1 (show HSF1 ELISA Kits), thereby stabilizing the mutant hERG (show KCNH2 ELISA Kits)-FLAG protein. Thus, M3-mAChR activators may have a therapeutic value for patients with LQT2 (show KCNH2 ELISA Kits).
There were no significant associations between CHRM3 SNPs and autonomic nervous system activity in patients with schizophrenia on high-dose antipsychotics.
To our knowledge, this is the first genetic association study that reveals the genetic contribution of CHRM3 gene in bladder cancer etiology.
The CHRM3 gene plays a role in abnormal thalamo-orbital frontal cortex functional connectivity in first-episode treatment-naive patients with schizophrenia.
These findings indicate that M3 mAChR may be important therapeutic target for obstructive airway diseases, as it regulates the effects of the epithelial-derived chemokines on ASM (show SMPD1 ELISA Kits) cell migration, which results in lung remodeling.
Blockading CHRM3 by shRNA or treatment with darifenacin inhibited prostate cancer growth.
Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp (show CLASRP ELISA Kits) and sling fibers similar to human clasp (show CLASRP ELISA Kits) and sling fibers.
Sequential activation of muscarinic M3 receptors and cannabinoid CB1 (show CNR1 ELISA Kits) receptors produce synergistic contractile effects of the bovine ciliary muscle by involving the activation of Rho-kinase (show ROCK1 ELISA Kits) and protein kinase C (show PKC ELISA Kits).
These data support the existence of a novel transducing cascade, involving Galpha (show SUCLG1 ELISA Kits)(q16)beta gamma coupling M(3)AChR to NPR (show NPTXR ELISA Kits)-GC.
airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C (show PLC ELISA Kits)/protein kinase C (show PKC ELISA Kits) pathway
Stimulation of the ERK (show EPHB2 ELISA Kits) pathway in Gnb5 (show GNB5 ELISA Kits)(-/-) cells by epidermal growth factor (show EGF ELISA Kits) restored M3R-stimulated insulin (show INS ELISA Kits) release to near normal levels. Identification of the novel role of Gbeta5 (show GNB5 ELISA Kits)-R7 in insulin (show INS ELISA Kits) secretion may lead to a new therapeutic approach for improving pancreatic beta-cell function
s. Moreover, we found that M3 cholinergic receptor (CHRM3) was upregulated in a large subset of benign prostatic hyperplasia (BPH (show GLI3 ELISA Kits)) tissues compared with normal tissues. Activation of CHRM3 also promoted the proliferation of BPH (show GLI3 ELISA Kits) cells.
early intervention with cholinergic receptor muscarinic (ChRM)-3 blocker reversed the progression of airway hyperreactivity in the neonatal exposure model, whereas beta2-adrenoceptor agonists had no such effect
Arthritis-induced joint destruction was significantly stronger in mice with M3 muscarinic acetylcholine receptor deficiency.
The effects of muscarinic receptor (show CHRM5 ELISA Kits) M3 knockout on cathepsin K (show CTSK ELISA Kits) expression, bone density and biomechanical properties of bone are reported.
results suggest that the autoantibodies against peptides of the second extracellular loop of M3R are not pathogenic in vivo and they are not suitable as biomarkers for pSS (show CDSN ELISA Kits) diagnosis
Expression of the M3 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras (show MRAS ELISA Kits)-/- males and females, although only males exhibited a urinary phenotype.
The study screened CrkL (show CRKL ELISA Kits) binding proteins using RNA interference (RNAi) and identified Sorbs1 (show SORBS1 ELISA Kits) and Sorbs2 (show Sorbs2 ELISA Kits) as two proteins that are enriched at AChR clusters and are required for the formation of AChR aggregation in vitro.
Activation of Chrm3 inhibits the recruitment of beta-arrestin-2 (show ARRB2 ELISA Kits) to odorant receptors, resulting in a potentiation of odor-induced responses in olfactory sensory neurons.
The muscarinic M3R receptor interacts directly with NOSTRIN (show NOSTRIN ELISA Kits) at the plasma membrane in the aorta.
G-protein coupled receptor, muscarinic receeptor subtype that mediates cholinergic-induced contraction in most smooth muscle
m3 muscarinic acetylcholine receptor
, muscarinic acetylcholine receptor M3
, cholinergic receptor, muscarinic 3
, acetylcholine receptor, muscarinic 3
, m3 muscarinic receptor
, cholinergic receptor, muscarinic 3, cardiac
, M3 muscarinic acetylcholine receptor
, AChR M3
, mm3 mAChR
, muscarinic acetylcholine receptor 3