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GluR7 kainate receptor subunit splice variants differentially traffic from the ER to the plasma membrane
GluR7, a kainate receptor (KAR (show HSD17B12 Proteins)) subunit with no known function in the brain, is identified as an essential subunit of presynaptic autoreceptors that facilitate hippocampal mossy fiber synaptic transmission.
additional experiment showed that the lymph node metastasis tissues had higher GRIK3 expression than their matched primary gastric cancer (GC) tissues. These findings suggested that elevated GRIK3 expression could serve as an independent prognostic biomarker and a novel potential treatment target for patients with GC.
GRIK3 expression is significantly downregulated in human masticatory mucosa during wound healing
1p34.3 deletion involving GRIK3: Further clinical implication of GRIK (show GRIK4 Proteins) family glutamate (show GRIN1 Proteins) receptors in the pathogenesis of developmental delay.
Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with alcohol dependence or any of its subgroups.
Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse
Some support (at a nominal significance level of 0.05/0.01) was found for association between GRIK3 and depression.
Our study suggests a potential role for GRIK3 for susceptibility to schizophrenia in Indian population.
Association between the ionotropic glutamate (show GRIN1 Proteins) receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.
Using three single nucleotide polymorphisms in GRIK2 (show GRIK2 Proteins) and one in GRIK3, we found no evidence for association with Obssessive-Compulsive disorder in case-control or family-based analyses.
suggestive for a significant role of GRIK3 polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. It is not certain if the subunit encoded by this gene is subject to RNA editing as the other 2 family members (GRIK1 and GRIK2). A Ser310Ala polymorphism has been associated with schizophrenia, and there are conflicting reports of its association with the pathogenesis of delirium tremens in alcoholics.
glutamate receptor, ionotropic, kainate 3
, glutamate receptor, ionotropic kainate 3
, ionotropic glutamate receptor subunit GluR7
, glutamate receptor 7
, glutamate receptor ionotropic, kainate 3
, glutamate receptor subunit kainate subtype
, dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))
, excitatory amino acid receptor 5