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Data suggest that the distinct spatial and temporal distribution patterns of KCTD8 (show KCTD8 Proteins), 12, 12b, and 16 underlie functional differences in native GABA(B) responses.
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
potassium channel tetramerisation domain containing 16
, BTB/POZ domain-containing protein KCTD16
, potassium channel tetramerization domain-containing protein 16